{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T16:40:01Z","timestamp":1648917601851},"reference-count":27,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2007,6,1]]},"abstract":"<jats:title>Absztrakt<\/jats:title><jats:p><jats:italic>C\u00e9l:<\/jats:italic>\u00d6sszehasonl\u00edtani a preoperat\u00edv alkalmazott kemo-radioter\u00e1pia (CRT) seg\u00edts\u00e9g\u00e9vel el\u00e9rt eredm\u00e9nyeinket k\u00fcl\u00f6nb\u00f6z\u0151 lokaliz\u00e1cioj\u00fa nyel\u0151cs\u0151 laph\u00e1mr\u00e1kok eset\u00e9ben.<\/jats:p><jats:p><jats:italic>M\u00f3dszer:<\/jats:italic>1997 \u00e9s 2005 k\u00f6z\u00f6tt klinik\u00e1nkon 102 el\u0151rehaladott st\u00e1diumban l\u00e9v\u0151 nyel\u0151cs\u0151r\u00e1kos beteg r\u00e9szes\u00fclt preoperat\u00edv kezel\u00e9sben. 40 esetben a daganat a nyel\u0151cs\u0151 fels\u0151 harmad\u00e1ban (I. csoport), 62 esetben a k\u00f6z\u00e9ps\u0151 harmad\u00e1ban (II. csoport) helyezkedett el. A t\u00fal\u00e9l\u00e9si eredm\u00e9nyeket t\u00f6rt\u00e9nelmi kontrollcsoporttal vetett\u00fck \u00f6ssze, majd a kombin\u00e1lt kezel\u00e9sben r\u00e9szes\u00fclt betegekn\u00e9l a k\u00fcl\u00f6nb\u00f6z\u0151 lokaliz\u00e1ci\u00f3j\u00fa csoportokat hasonl\u00edtottuk \u00f6ssze.<\/jats:p><jats:p><jats:italic>Eredm\u00e9nyek:<\/jats:italic>A t\u00f6rt\u00e9nelmi kontrollcsoporttal t\u00f6rt\u00e9nt \u00f6sszevet\u00e9s szignifik\u00e1ns t\u00fal\u00e9l\u00e9sbeni javul\u00e1st igazolt a neoadjuv\u00e1ns kezel\u00e9s hat\u00e1s\u00e1ra (p:0,0042). Az I-es csoportban 70%-ban ker\u00fclt sor reszekci\u00f3ra, ezek 50%-\u00e1ban komplett patol\u00f3giai remisszi\u00f3 (pCR) volt megfigyelhet\u0151. A perioperat\u00edv morbidit\u00e1s 43%-os, a perioperat\u00edv mortalit\u00e1s 14%-os volt. A II-es csoportban 69%-ban v\u00e9gezt\u00fcnk reszekci\u00f3t, pCR-t 7%-ban \u00e9szlelt\u00fcnk. A perioperat\u00edv morbidit\u00e1sunk 62%, a perioperat\u00edv mortalit\u00e1sunk 18%-nak ad\u00f3dott. Az R0 reszekci\u00f3k ar\u00e1nya (82% vs. 84%) \u00e9s az \u00e1tlagos t\u00fal\u00e9l\u00e9s (21 vs. 22 h\u00f3nap) hasonl\u00f3 volt a k\u00e9t csoportban, azonban a pCR szignifik\u00e1nsan jobb t\u00fal\u00e9l\u00e9st jelentett.<\/jats:p><jats:p><jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>A multimod\u00e1lis kezel\u00e9s alkalmaz\u00e1sa jav\u00edtja a t\u00fal\u00e9l\u00e9st lok\u00e1lisan el\u0151rehaladott nyel\u0151cs\u0151 laph\u00e1mr\u00e1kok eset\u00e9n. Az I. csoportban \u00e9szlelt szignifik\u00e1nsan t\u00f6bb komplett patol\u00f3giai remisszi\u00f3 alapj\u00e1n \u00fagy t\u0171nik, hogy a fels\u0151 harmadi lokaliz\u00e1ci\u00f3j\u00fa nyel\u0151cs\u0151 laph\u00e1mr\u00e1kok jobban reag\u00e1lnak a multimod\u00e1lis kezel\u00e9sre, mely \u00faj prognosztikai t\u00e9nyez\u0151k\u00e9nt szerepelhet a lok\u00e1lisan el\u0151rehaladott nyel\u0151cs\u0151r\u00e1kok kezel\u00e9s\u00e9ben.<\/jats:p>","DOI":"10.1556\/maseb.60.2007.3.1","type":"journal-article","created":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T12:59:32Z","timestamp":1192798772000},"page":"123-129","source":"Crossref","is-referenced-by-count":6,"title":["A preoperat\u00edv kemo-radioter\u00e1pia hat\u00e1sa az el\u0151rehaladott fels\u0151 \u00e9s k\u00f6z\u00e9ps\u0151 harmadi nyel\u0151cs\u0151 laph\u00e1mr\u00e1kok 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