{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T01:07:24Z","timestamp":1694826444547},"reference-count":19,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2007,6,1]]},"abstract":"<jats:title>Absztrakt<\/jats:title><jats:p>A szerz\u0151k az ut\u00f3bbi 5 \u00e9vben oper\u00e1lt colorectalis eredet\u0171 t\u00fcd\u0151 metastasisok seb\u00e9szi kezel\u00e9s\u00e9nek retrospektiv \u00e9rt\u00e9kel\u00e9s\u00e9r\u0151l sz\u00e1molnak be. Megvizsg\u00e1lj\u00e1k a colorectalis tumorok pulmonalis \u00e1tt\u00e9tk\u00e9pz\u00e9s\u00e9nek saj\u00e1ts\u00e1gait \u00e9s a t\u00fal\u00e9l\u00e9st befoly\u00e1sol\u00f3 prognosztikus faktorokat, valamint \u00f6sszevetik saj\u00e1t tapasztalataikat a nemzetk\u00f6zi szakirodalommal.<\/jats:p><jats:p>2001 \u00e9s 2005 k\u00f6z\u00f6tt 33 betegen 37 m\u0171t\u00e9tet v\u00e9geztek. A betegek k\u00f6z\u00f6tt 14 n\u0151 \u00e9s 19 f\u00e9rfi volt, \u00e1tlag\u00e9letkoruk 61.3 \u00e9v (49\u201376 \u00e9v). A m\u0171t\u00e9ti t\u00edpust, a betegs\u00e9gmentes id\u0151szakot (Disease Free Interval, DFI), az oldalis\u00e1got, az \u00e1tt\u00e9tsz\u00e1mot, a lokaliz\u00e1ci\u00f3t, a nyirokcsom\u00f3 \u00e9rintetts\u00e9get, valamint a m\u00e1j metastasisok jelenl\u00e9t\u00e9t vizsg\u00e1lt\u00e1k lehets\u00e9ges prognosztikus faktork\u00e9nt. A 37 m\u0171t\u00e9t k\u00f6z\u00fcl 20 szoliter, 17 multiplex elv\u00e1ltoz\u00e1s miatt t\u00f6rt\u00e9nt. 25 esetben atypusos resectiot, 12 lobectomi\u00e1t (melyb\u0151l 1 sleeve resectio) \u00e9s 1 esetben pulmonectomi\u00e1t v\u00e9geztek. 18 betegn\u00e9l jobb, 9 betegn\u00e9l bal oldali, \u00e9s 6 betegn\u00e9l k\u00e9toldali folyamatot oper\u00e1ltak. Hat p\u00e1ciensn\u00e9l synchron ill. metachron hepaticus metastasis miatt m\u00e1j resectio is t\u00f6rt\u00e9nt.<\/jats:p><jats:p>A t\u00fal\u00e9l\u00e9st Kaplan\u2013Meier m\u00f3dszerrel, a t\u00fcd\u0151 resectio id\u0151pontj\u00e1t\u00f3l kezd\u0151d\u0151en sz\u00e1m\u00edtott\u00e1k. Az \u00e1tlagos betegs\u00e9gmentes id\u0151szak 27.6 h\u00f3nap volt. A teljes beteganyagra vonatkoztatott \u00e1tlagos t\u00fal\u00e9l\u00e9s 28 h\u00f3nap volt. Ha csak t\u00fcd\u0151 metastasis jelentkezett, a 3 \u00e9ves t\u00fal\u00e9l\u00e9s 52% volt.<\/jats:p><jats:p>A colorectalis tumor ut\u00e1ni t\u00fcd\u0151\u00e1tt\u00e9tek resectioja kedvez\u0151en befoly\u00e1solja a t\u00fal\u00e9l\u00e9st. A v\u00e1rakoz\u00e1ssal szemben, az oper\u00e1lt szoliter ill. multiplex metastasisok (max. 7 metastasis) t\u00fal\u00e9l\u00e9si eredm\u00e9nyei k\u00f6z\u00f6tt nem tal\u00e1ltak szignifik\u00e1ns elt\u00e9r\u00e9st. A vizsg\u00e1lt beteganyagban a region\u00e1lis nyirokcsom\u00f3 \u00e1tt\u00e9tes betegek t\u00fal\u00e9l\u00e9se \u00e1tlagosan 12 h\u00f3nappal r\u00f6videbb, mint a nyirokcsom\u00f3 negat\u00edv esetek\u00e9. A relat\u00edve alacsony esetsz\u00e1m miatt a statisztikai k\u00f6vetkeztet\u00e9s korl\u00e1tozott. A szakirodalom megfigyel\u00e9seivel ellent\u00e9tben nem \u00e9szlelt\u00e9k, hogy a 24 h\u00f3napn\u00e1l hosszabb DFI ut\u00e1n szignifik\u00e1nsan hosszabb lenne a t\u00fal\u00e9l\u00e9s. A synchron ill. metachron m\u00e1j\u00e1tt\u00e9ttel rendelkez\u0151 6 beteg \u00e1tlagos t\u00fal\u00e9l\u00e9se 10 h\u00f3nappal r\u00f6videbb a t\u00f6bbi beteg\u00e9n\u00e9l, de az alacsony esetsz\u00e1m miatt ez nem bizony\u00edt\u00f3 erej\u0171. A vizsg\u00e1lt t\u00f6bbi faktornak (lokaliz\u00e1ci\u00f3, \u00e1tt\u00e9tsz\u00e1m, oldalis\u00e1g) anal\u00edzis\u00fck szerint nincs prediktiv \u00e9rt\u00e9ke.<\/jats:p>","DOI":"10.1556\/maseb.60.2007.3.2","type":"journal-article","created":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T12:59:32Z","timestamp":1192798772000},"page":"130-135","source":"Crossref","is-referenced-by-count":3,"title":["A colorectalis tumorok t\u00fcd\u0151 metastasisainak seb\u00e9szi kezel\u00e9ser"],"prefix":"10.1556","volume":"60","author":[{"given":"Istv\u00e1n","family":"Zapf","sequence":"first","affiliation":[{"name":"1 Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Ifj\u00fas\u00e1g u. 13."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F Tam\u00e1s","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Ifj\u00fas\u00e1g u. 13."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Benk\u0151","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Ifj\u00fas\u00e1g u. 13."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1roly","family":"Kalm\u00e1r Nagy","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Ifj\u00fas\u00e1g u. 13."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zal\u00e1n","family":"Sz\u00e1nt\u00f3","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Ifj\u00fas\u00e1g u. 13."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"P\u00f3t\u00f3","sequence":"additional","affiliation":[{"name":"2 Bioanalitikai Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6rs P\u00e9ter","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Ifj\u00fas\u00e1g u. 13."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","first-page":"431","article-title":"Combined multimodal treatment for liver and lung metastasis from colorectal cancer: a new therapeutic option?","volume":"53","author":"Ciferri E","year":"2001","journal-title":"Chir Ital"},{"key":"2","first-page":"93","article-title":"Medium and long-term results of the use of videothorascopy in surgery of pulmonary metastasis resection.","volume":"28","author":"Torre W","year":"2005","journal-title":"An Sist Sanit Nava"},{"key":"3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1067\/mtc.2002.125165","article-title":"Pulmonary metastasectomy for 165 patients with colorectal carcinoma: A prognostic assessment.","volume":"12","author":"Saito Y","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.athoracsur.2006.02.027","article-title":"Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer.","volume":"8","author":"Iizasa T","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"5","first-page":"206","article-title":"D\u00f6nt\u00e9sanalizis \u00e9s praxeologia az orvosi gyakorlatban. 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