{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T15:44:33Z","timestamp":1648655073738},"reference-count":22,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Absztrakt<\/jats:title>\n        <jats:p>A korai st\u00e1dium\u00fa (stage I\u2013II) eml\u0151r\u00e1kok miatt v\u00e9gzett eml\u0151megtart\u00f3 m\u0171t\u00e9tek ut\u00e1ni lok\u00e1lis recid\u00edv\u00e1knak (LR) sz\u00e1mos hajlamos\u00edt\u00f3 t\u00e9nyez\u0151j\u00e9t eml\u00edti a szakirodalom, de egyes faktorok jelent\u0151s\u00e9ge nem egy\u00e9rtelm\u0171. Ilyen az intraductalis komponens (IC) jelenl\u00e9te, melyet a szerz\u0151k egy r\u00e9sze az LR predikt\u00edv faktor\u00e1nak tekint, m\u00e1sok nem, vagy csak egy\u00e9b t\u00e9nyez\u0151kkel val\u00f3 egy\u00fcttes jelenl\u00e9tekor tal\u00e1ltak \u00f6sszef\u00fcgg\u00e9st az LR-rel. A szerz\u0151k vizsg\u00e1latukban arra a k\u00e9rd\u00e9sre kerest\u00e9k a v\u00e1laszt, hogy beteganyagukban az IC k\u00fcl\u00f6nb\u00f6z\u0151 m\u00e9rt\u00e9k\u0171 jelenl\u00e9te mennyiben befoly\u00e1solja az LR m\u00e9rt\u00e9k\u00e9t k\u00fcl\u00f6nb\u00f6z\u0151 tumorm\u00e9retek \u00e9s sz\u00f6vettani anaplasiafokok mellett. 1996 \u00e9s 2002 k\u00f6z\u00f6tt 701 betegn\u00e9l v\u00e9geztek eml\u0151megtart\u00f3 m\u0171t\u00e9tet korai st\u00e1dium\u00fa eml\u0151r\u00e1k miatt. Az IC szempontj\u00e1b\u00f3l a daganatokat 3 csoportba osztott\u00e1k: IC-negat\u00edv, ha intraductalis komponens nem volt kimutathat\u00f3, MIC (IC &lt; 25%), ha az intraductalis komponens az \u00f6ssztumormennyis\u00e9g 25%-\u00e1n\u00e1l kisebb volt, \u00e9s EIC (IC &gt; 25%), ha 25%-n\u00e1l nagyobb m\u00e9rt\u00e9kben volt jelen. 65 h\u00f3napos \u00e1tlagos k\u00f6vet\u00e9si id\u0151 alatt 13,5%-ban \u00e9szleltek LR-t. IC n\u00e9lk\u00fcli daganat eset\u00e9ben 8,7%-ban (recid\u00edvar\u00e1ta: 0,017, 95% CI: 0,012\u20130,023) jelentkezett helyi ki\u00fajul\u00e1s, ugyanezek az \u00e9rt\u00e9kek MIC \u00e9s EIC eset\u00e9ben 16,8%-ra (recid\u00edvar\u00e1ta: 0,032, 95% CI: 0,021\u20130,047), illetve 25,6%-ra (recid\u00edvar\u00e1ta: 0,046, 95% CI: 0,033\u20130,064) emelkedtek (<jats:italic>p<\/jats:italic> = 0,0001). T1 tumorm\u00e9ret eset\u00e9ben a fenti \u00e9rt\u00e9kek 6,4%, 11% \u00e9s 24,3%-nak, T2 eset\u00e9ben 11,5%, 22,9% \u00e9s 27%-nak ad\u00f3dtak (<jats:italic>p<\/jats:italic> &lt; 0,005). Ha az EIC G3 differenci\u00e1lts\u00e1gi fokkal t\u00e1rsult, \u00fagy T1 tumorm\u00e9ret eset\u00e9n az IC n\u00e9lk\u00fcli 6,9%-r\u00f3l 31%-ra (<jats:italic>p<\/jats:italic> = 0,008), T2 eset\u00e9n 15,7%-r\u00f3l 33,3%-ra n\u0151tt az LR el\u0151fordul\u00e1si gyakoris\u00e1ga (<jats:italic>p<\/jats:italic> = 0,02). Az eredm\u00e9nyekb\u0151l a szerz\u0151k azt \u00e1llap\u00edtj\u00e1k meg, hogy az intraductalis komponens jelenl\u00e9te \u00f6nmag\u00e1ban is az LR fell\u00e9pt\u00e9nek nagyobb vesz\u00e9ly\u00e9t jelenti, mely kock\u00e1zat jelent\u0151sen n\u00f6vekszik, amennyiben az EIC G3 sz\u00f6vettani grade-del t\u00e1rsul. A kiemelt kock\u00e1zat\u00fa betegek egy\u00e9nre szabott adjuv\u00e1ns kezel\u00e9s\u00e9nek megtervez\u00e9sekor ezt a t\u00e9nyt felt\u00e9tlen\u00fcl tekintetbe kell venni. Ezen betegcsoport ut\u00e1nk\u00f6vet\u00e9s\u00e9re fokozott figyelmet kell ford\u00edtani.<\/jats:p>","DOI":"10.1556\/maseb.61.2008.1.3","type":"journal-article","created":{"date-parts":[[2008,4,12]],"date-time":"2008-04-12T00:20:32Z","timestamp":1207959632000},"page":"12-17","source":"Crossref","is-referenced-by-count":1,"title":["Az intraductalis komponens jelent\u0151s\u00e9ge az eml\u0151r\u00e1k eml\u0151megtart\u00f3 m\u0171t\u00e9tei ut\u00e1n fell\u00e9p\u0151 lok\u00e1lis recid\u00edv\u00e1k l\u00e9trej\u00f6tt\u00e9benr"],"prefix":"10.1556","volume":"61","author":[{"given":"Zolt\u00e1n","family":"Garami","sequence":"first","affiliation":[{"name":"1 Seb\u00e9szeti Int\u00e9zet, Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, 4012, Debrecen, Pf. 27"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korn\u00e9lia","family":"Szluha","sequence":"additional","affiliation":[{"name":"2 Sug\u00e1rter\u00e1pi\u00e1s Tansz\u00e9k, Debreceni 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