{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T06:26:30Z","timestamp":1648621590535},"reference-count":21,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Absztrakt<\/jats:title>\n        <jats:p>A szerz\u0151 a magyarorsz\u00e1gi m\u00e1j\u00e1t\u00fcltet\u00e9si program adatait elemzi (1995\u20132006 k\u00f6z\u00f6tt), retrospekt\u00edv vizsg\u00e1lattal. A hepatitis C-v\u00edrus (HCV) talaj\u00e1n kialakult cirrhosis miatt v\u00e9gzett m\u00e1j\u00e1t\u00fcltet\u00e9seket k\u00fcl\u00f6n elemzi. \u00d6sszef\u00fcgg\u00e9st keres a korai C-v\u00edrus-rekurrencia \u00e9s a sz\u00e9rumban m\u00e9rt HCV-RNS-titer, valamint a graftbiopszi\u00e1kban \u00e9szlelt sz\u00f6vettani elv\u00e1ltoz\u00e1sok \u00e9s a PCR-m\u00f3dszerrel vizsg\u00e1lt, endoplazmatikus reticulum stresszt moder\u00e1l\u00f3 hepatocellularis chaperonok expressi\u00f3ja k\u00f6z\u00f6tt. Ismerteti, hogy a m\u0171t\u00e9tek sz\u00e1ma 10 \u00e9v alatt megn\u00e9gyszerez\u0151d\u00f6tt. Az id\u0151szakokra bontott 1, 3 \u00e9s 5 \u00e9ves kumulat\u00edv betegt\u00fal\u00e9l\u00e9s 55%, 45% \u00e9s 39% (1995\u20131997), 72%, 64% \u00e9s 61% (1998\u20132000), illetve 78%, 77% \u00e9s 77% (2001\u20132004) volt. A teljes mortalit\u00e1s 53%-r\u00f3l 31%-ra, a 60 napon bel\u00fcli hal\u00e1loz\u00e1s 24%-r\u00f3l 5%-ra cs\u00f6kkent. A HCV miatt transzplant\u00e1lt betegek 1, 3 \u00e9s 5 \u00e9ves kumulat\u00edv t\u00fal\u00e9l\u00e9se 64%, 55% \u00e9s 51%, minden m\u00e1s kr\u00f3nikus indik\u00e1ci\u00f3 eset\u00e9n ez 73%, 66% \u00e9s 63% volt. A HCV miatt transzplant\u00e1ltakn\u00e1l az 1 \u00e9ven bel\u00fcl \u00e9szlelt v\u00edruski\u00fajul\u00e1s ar\u00e1nya 43% volt \u00f6sszess\u00e9g\u00e9ben. A betegt\u00fal\u00e9l\u00e9st befoly\u00e1sol\u00f3 t\u00e9nyez\u0151k Cox-regresszi\u00f3s multivari\u00e1ci\u00f3s anal\u00edzise alapj\u00e1n a m\u0171t\u00e9t ut\u00e1ni veseel\u00e9gtelens\u00e9g, a hepaticus art\u00e9ria thrombosisa, epe\u00fati necrosis, cholangitis, valamint a pulmonalis \u00e9s has\u00fcregi fert\u0151z\u00e9s, intraoperat\u00edv kolloid inf\u00fazi\u00f3 (HES) \u00e9s a v\u00e9rtranszf\u00fazi\u00f3 mennyis\u00e9ge voltak. A HCV miatt m\u00e1j\u00e1t\u00fcltetett betegek posztoperat\u00edv biopszi\u00e1iban az XBP1, ATF6, HSP70, GRP98, GP96, Calnexin \u00e9s Calreticulin chaperonok expressi\u00f3ja szignifik\u00e1nsan magasabb volt az interferonkezel\u00e9s el\u0151tt, mint egy \u00e9v antivir\u00e1lis kezel\u00e9s ut\u00e1n, f\u00fcggetlen\u00fcl a sz\u00e9rumban m\u00e9rt v\u00edrus-RNS-titert\u0151l. Acut rejectio eset\u00e9n a chaperonexpressio szignifik\u00e1nsan \u00e9s nagys\u00e1grenddel kifejezettebb volt, mint a hepatitis C-v\u00edrus reaktiv\u00e1ci\u00f3j\u00e1nak sz\u00f6vettani jelei eset\u00e9n. Meg\u00e1llap\u00edtja, hogy a HCV miatt v\u00e9gzett m\u00e1j\u00e1t\u00fcltet\u00e9sek ut\u00e1n, a korai v\u00edruski\u00fajul\u00e1s \u00f6sszef\u00fcgg\u00e9sbe hozhat\u00f3 a m\u00e1j\u00e1t\u00fcltet\u00e9s ut\u00e1n a sz\u00e9rumban m\u00e9rt emelkedett v\u00edrus-RNS-titerrel. Ez sz\u00e1mszer\u0171en is kifejezhet\u0151 egy hat\u00e1r\u00e9rt\u00e9k form\u00e1j\u00e1ban, amely felett a sz\u00f6vettani jelek \u00e9s a klinikum is progressz\u00edv m\u00e1jk\u00e1rosod\u00e1st jelez. Ezekn\u00e9l a betegekn\u00e9l a statisztikai t\u00fal\u00e9l\u00e9s is rosszabb.<\/jats:p>","DOI":"10.1556\/maseb.61.2008.1.9","type":"journal-article","created":{"date-parts":[[2008,4,12]],"date-time":"2008-04-12T00:20:32Z","timestamp":1207959632000},"page":"42-47","source":"Crossref","is-referenced-by-count":3,"title":["A magyar m\u00e1j\u00e1t\u00fcltet\u00e9si program eredm\u00e9nyeit befoly\u00e1sol\u00f3 egyes t\u00e9nyez\u0151k, k\u00fcl\u00f6n\u00f6s tekintettel a hepatitis C-v\u00edrusrar"],"prefix":"10.1556","volume":"61","author":[{"given":"Bal\u00e1zs","family":"Nemes","sequence":"first","affiliation":[{"name":"1 Transzplant\u00e1ci\u00f3s \u00e9s Seb\u00e9szeti Klinika, Semmelweis Egyetem, 1082, Budapest, Baross u. 23."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","first-page":"659","article-title":"Homotransplantation of the liver in human","volume":"117","author":"Starzl TE","year":"1963","journal-title":"Surg Gynecol Obstet"},{"key":"2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/bmj.4.5630.535","article-title":"Liver transplantation in man. 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