{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T21:42:22Z","timestamp":1758922942944,"version":"3.38.0"},"reference-count":12,"publisher":"Akademiai Kiado Zrt.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:title>Absztrakt<\/jats:title><jats:p><jats:italic>Bevezet\u00e9s\/c\u00e9lkit\u0171z\u00e9s:<\/jats:italic>A hasfali s\u00e9rvek laparoscopos megold\u00e1s\u00e1ban a seb\u00e9szi h\u00e1l\u00f3 intraperitonealis poz\u00edci\u00f3ban ker\u00fcl be\u00fcltet\u00e9sre. \u00c1llatmodellekben \u00e9s a hum\u00e1ngyakorlatban egyar\u00e1nt \u00edg\u00e9retesek a kombin\u00e1lt, t\u00f6bbr\u00e9teg\u0171 h\u00e1l\u00f3k. Jelen k\u00eds\u00e9rlet c\u00e9lja k\u00e9t elt\u00e9r\u0151 szerkezet\u0171, szilikonbevonat\u00fa polipropil\u00e9n h\u00e1l\u00f3 biol\u00f3giai viselked\u00e9s\u00e9nek \u00f6sszehasonl\u00edt\u00e1sa volt.<jats:italic>Anyag \u00e9s m\u00f3dszerek:<\/jats:italic>\u00daj-z\u00e9landi feh\u00e9r nyulak hasfal\u00e1n egy 3 \u00d7 4 cm nagys\u00e1g\u00fa, teljes vastags\u00e1g\u00fa hasfaldefektust k\u00e9sz\u00edtett\u00fcnk, melyet \u00f6sszetett h\u00e1l\u00f3val fedt\u00fcnk. 20 \u00e1llatba a felsz\u00edn\u00e9n lamin\u00e1ris szilikonr\u00e9teggel bevont h\u00e1l\u00f3t (LSPP), a m\u00e1sik 20 ny\u00fal eset\u00e9ben szilikonnal impregn\u00e1lt polipropil\u00e9n filamentumb\u00f3l sz\u0151tt h\u00e1l\u00f3t (MSPP) \u00fcltett\u00fcnk be. Az intraperitonealis adhaesiok\u00e9pz\u0151d\u00e9s m\u00e9rt\u00e9k\u00e9t \u00e9s a h\u00e1l\u00f3k be\u00e9p\u00fcl\u00e9s\u00e9t vizsg\u00e1ltuk. Immunhisztok\u00e9miai m\u00f3dszerrel az oszt\u00f3d\u00f3 sejtek jelenl\u00e9t\u00e9t \u00e9s eloszl\u00e1s\u00e1t az idegen anyag k\u00f6rnyezet\u00e9ben (Ki-67), az \u00e9r\u00fajdonk\u00e9pz\u0151d\u00e9st (VEGF) \u00e9s a kialakul\u00f3 neoperitoneum-r\u00e9teget (CK) vizsg\u00e1ltuk, scanning elektronmikroszk\u00f3ppal a hal\u00f3k felsz\u00edn\u00e9t tanulm\u00e1nyoztuk.<jats:italic>Eredm\u00e9nyek:<\/jats:italic>Az intraperitonealis adhaesiok\u00e9pz\u0151d\u00e9s m\u00e9rt\u00e9ke az els\u0151 h\u00e9ten nem mutatott elt\u00e9r\u00e9st, m\u00edg a harmadik h\u00e9ten az LSPP szignifik\u00e1nsan kevesebb kitapad\u00e1st gener\u00e1lt. A Ki-67 antitest jel\u00f6l\u00e9s szignifik\u00e1nsan alacsonyabb aktivit\u00e1s\u00fa volt a makropor\u00f3zus h\u00e1l\u00f3k csoportj\u00e1ban. Ugyanebben a csoportban a VEGF pozitivit\u00e1s id\u0151ar\u00e1nyosan n\u0151tt, m\u00edg az LSPP eset\u00e9ben nem v\u00e1ltozott. A v\u00e9kony neoperitoneum-r\u00e9teg csak a makropor\u00f3zus h\u00e1l\u00f3 felsz\u00edn\u00e9n volt sz\u00f6vettanilag kimutathat\u00f3 (CK jel\u00f6l\u00e9s), az LSPP eset\u00e9ben hi\u00e1nyzott.<jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>A seb\u00e9szi h\u00e1l\u00f3 alapanyaga \u00e9s text\u00far\u00e1ja is meghat\u00e1roz\u00f3 szerepet j\u00e1tszik a befogad\u00f3 sz\u00f6vetbe t\u00f6rt\u00e9n\u0151 integr\u00e1ci\u00f3ban, mely ar\u00e1nyos a kiv\u00e1ltott idegentest-reakci\u00f3val.<\/jats:p>","DOI":"10.1556\/maseb.63.2010.5.8","type":"journal-article","created":{"date-parts":[[2010,10,22]],"date-time":"2010-10-22T01:13:38Z","timestamp":1287710018000},"page":"340-346","source":"Crossref","is-referenced-by-count":4,"title":["A k\u00fcl\u00f6nb\u00f6z\u0151 szilikonbevonat\u00fa polipropil\u00e9n h\u00e1l\u00f3k sz\u00f6veti integr\u00e1ci\u00f3ja"],"prefix":"10.1556","volume":"63","author":[{"given":"Ildik\u00f3","family":"Tak\u00e1cs","sequence":"first","affiliation":[{"name":"1 Seb\u00e9szeti Oktat\u00f3 \u00e9s Kutat\u00f3 Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Kod\u00e1ly Zolt\u00e1n u. 20."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Oktat\u00f3 \u00e9s Kutat\u00f3 Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Kod\u00e1ly Zolt\u00e1n u. 20."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borb\u00e1la","family":"Balatonyi","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Oktat\u00f3 \u00e9s Kutat\u00f3 Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Kod\u00e1ly Zolt\u00e1n u. 20."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szaniszl\u00f3","family":"J\u00e1vor","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Oktat\u00f3 \u00e9s Kutat\u00f3 Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Kod\u00e1ly Zolt\u00e1n u. 20."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Oktat\u00f3 \u00e9s Kutat\u00f3 Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Kod\u00e1ly Zolt\u00e1n u. 20."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarolta","family":"G\u00e1sp\u00e1r","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Oktat\u00f3 \u00e9s Kutat\u00f3 Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Kod\u00e1ly Zolt\u00e1n u. 20."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeka","family":"Haj\u00f3s","sequence":"additional","affiliation":[{"name":"2 Hisztopatol\u00f3gia Kft., P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Meczker","sequence":"additional","affiliation":[{"name":"2 Hisztopatol\u00f3gia Kft., P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Lantos","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Oktat\u00f3 \u00e9s Kutat\u00f3 Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Kod\u00e1ly Zolt\u00e1n u. 20."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"R\u0151th","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Oktat\u00f3 \u00e9s Kutat\u00f3 Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Kod\u00e1ly Zolt\u00e1n u. 20."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"W\u00e9ber","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Oktat\u00f3 \u00e9s Kutat\u00f3 Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, 7624, P\u00e9cs, Kod\u00e1ly Zolt\u00e1n u. 20."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"volume-title":"Meshes: benefits and risks","year":"2004","author":"Offner EA","key":"1"},{"key":"2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.amjsurg.2008.11.003","article-title":"Polyester-based mesh for ventral hernia repair: is it safe?","volume":"197","author":"Rosen MJ","year":"2009","journal-title":"Am J Surg"},{"key":"3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000129188","article-title":"A comparison of intraperitoneal prostheses for the repair of abdominal muscular wall defects in rat","volume":"24","author":"Pans A","year":"1992","journal-title":"Eur Surg Res"},{"key":"4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0002-9610(02)00907-8","article-title":"The structure of a biomaterial rather than its chemical composition modulates the repair process at the peritoneal level","volume":"14","author":"Bellon JM","year":"2002","journal-title":"Am J Surg"},{"key":"5","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1177\/000313480206801102","article-title":"Comparison of adhesion formation to intra-abdominal mesh after laparoscopic adhesiolysis in the New Zealand White rabbit","volume":"68","author":"Matthews BD","year":"2002","journal-title":"Am Surg"},{"key":"6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00000658-200301000-00017","article-title":"Prevention of adhesion to prosthetic mesh comparison of different barriers using an incisional hernia model","volume":"237","author":"Riet M","year":"2003","journal-title":"Ann Surg"},{"key":"7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1089\/lap.2006.0028","article-title":"Peritoneal effects of prosthetic meshes used to repair abdominal wall defects: monitoring adhesions by sequential laparoscopy","volume":"17","author":"Bellon JM","year":"2007","journal-title":"J Lap & Adv Surg Tech"},{"key":"8","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1159\/000073388","article-title":"Serum and drainage fluid vascular endothelial growth factor levels in early surgical wounds","volume":"35","author":"Karayiannakis AJ","year":"2003","journal-title":"Eur Surg Res"},{"key":"9","first-page":"375","article-title":"Adjuvant cytokeratin staining in Mohs micrographic surgery for basal cell carcinoma","volume":"29","author":"Smeet NW","year":"2003","journal-title":"Dermatol Surg"},{"key":"10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1464-410X.2006.06190.x","article-title":"Immunohistochemical analysis of negative inguinal lymph nodes in men with squamous cell carcinoma of the penis: are we missing micrometastases which could predict recurrence?","volume":"98","author":"Biedrzycki OJ","year":"2006","journal-title":"BJU Int"},{"key":"11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/bjs.6446","article-title":"Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model","volume":"96","author":"Schreinemacher MH","year":"2009","journal-title":"Br J Surg"},{"key":"12","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1007\/s00464-005-0473-2","article-title":"Omentum prevents intestinal adhesions to mesh graft in abdominal infections and serosal defects","volume":"20","author":"Karabulut B","year":"2006","journal-title":"Surg Endosc"}],"container-title":["Magyar Seb\u00e9szet"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/1046\/63\/5\/article-p340.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akademiai.com\/doi\/pdf\/10.1556\/maseb.63.2010.5.8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T01:20:53Z","timestamp":1740619253000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/maseb.63.2010.5.8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,1]]},"references-count":12,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1556\/maseb.63.2010.5.8","relation":{},"ISSN":["0025-0295","1789-4301"],"issn-type":[{"type":"print","value":"0025-0295"},{"type":"electronic","value":"1789-4301"}],"subject":[],"published":{"date-parts":[[2010,10,1]]}}}