{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:52:58Z","timestamp":1775807578246,"version":"3.50.1"},"reference-count":36,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:title>Absztrakt<\/jats:title><jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic>\u00c1tmeneti ischaemia kapcs\u00e1n az ischaemia\/reperfusi\u00f3s (IR) k\u00e1rosod\u00e1s els\u0151dleges c\u00e9lpontja az erek endotheliuma, m\u00edg interstitialis cystitisben \u00e9s haemorrhagi\u00e1s cystitisben a gyullad\u00e1s az epithelium\/urothelium fel\u0151l indul, \u00e9s az interstitium fel\u00e9 terjedhet, \u00edgy okozva m\u00e1sodlagos mikrokering\u00e9si v\u00e1ltoz\u00e1sokat. Vizsg\u00e1lataink c\u00e9lja a nem fert\u0151z\u00e9ses eredet\u0171 cystitisek \u00e9s a h\u00f3lyag IR mikrokering\u00e9si k\u00f6vetkezm\u00e9nyeinek vizsg\u00e1lata, valamint a kering\u00e9si reakci\u00f3k \u00f6sszehasonl\u00edt\u00f3 elemz\u00e9se volt.<jats:italic>M\u00f3dszerek:<\/jats:italic>H\u00edm Sprague Dawley-patk\u00e1nyokban protamin-szulf\u00e1t (2 mg \/ 200 \u03bcl s\u00f3oldatban,<jats:italic>n<\/jats:italic>= 6) 30 perces intravesicalis instillati\u00f3j\u00e1val gyullad\u00e1st induk\u00e1ltunk, a m\u00e1sodik csoportban (<jats:italic>n<\/jats:italic>= 5) ciklofoszfamidot (75 mg\/kg, i.p.) alkalmaztunk 24 \u00f3r\u00e1val a vizsg\u00e1lat el\u0151tt. A harmadik csoportban (<jats:italic>n<\/jats:italic>= 5) a h\u00fagyh\u00f3lyag \u00e1tmeneti ischaemi\u00e1j\u00e1t id\u00e9zt\u00fck el\u0151 a h\u00f3lyagot ell\u00e1t\u00f3 erek 60 perces leszor\u00edt\u00e1s\u00e1val. A kezeletlen kontrollcsoportban a h\u00fagyh\u00f3lyagot fiziol\u00f3gi\u00e1s s\u00f3oldattal instill\u00e1ltuk (<jats:italic>n<\/jats:italic>= 5). A gyullad\u00e1sos mikrokering\u00e9si reakci\u00f3kat intravit\u00e1lis fluoreszcens videomikroszk\u00f3ppal vizsg\u00e1ltuk 60 perc reperfusio ut\u00e1n, illetve 24 \u00f3r\u00e1val a protamin-szulf\u00e1t-instillati\u00f3t vagy ciklofoszfamid-kezel\u00e9st k\u00f6vet\u0151en.<jats:italic>Eredm\u00e9nyek:<\/jats:italic>A g\u00f6rd\u00fcl\u0151 leukocyt\u00e1k ar\u00e1nya h\u00e1romszoros\u00e1ra n\u00f6vekedett a h\u00f3lyag posztkapill\u00e1ris ereiben a protamin-szulf\u00e1t-modellben, a ciklofoszfamid-csoportban \u00f6tsz\u00f6r\u00f6s, az IR csoportban hat \u00e9s f\u00e9lszeres volt a n\u00f6veked\u00e9s. A leukocyt\u00e1k kitapad\u00e1sa mindh\u00e1rom k\u00eds\u00e9rletes csoportban hasonl\u00f3 m\u00e9rt\u00e9kben (k\u00f6zel h\u00e9tszeres\u00e9re) fokoz\u00f3dott. A v\u00f6r\u00f6sv\u00e9rtestek \u00e1raml\u00e1si sebess\u00e9ge a protamin-szulf\u00e1t- \u00e9s IR csoportban cs\u00f6kkent, m\u00edg a ciklofoszfamid-csoportban kism\u00e9rt\u00e9kben emelkedett.<jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>Eredm\u00e9nyeink alapj\u00e1n nemcsak a direkt endotheliums\u00e9r\u00fcl\u00e9st okoz\u00f3 IR, de a protamin-szulf\u00e1t \u00e9s a ciklofoszfamid alkalmaz\u00e1sa is mikrokering\u00e9si v\u00e1ltoz\u00e1sokat id\u00e9z el\u0151 a patk\u00e1ny h\u00fagyh\u00f3lyag\u00e1ban. Ezek az eredm\u00e9nyek felvetik a mikrokering\u00e9si zavarok k\u00f3roki szerep\u00e9t az irrit\u00e1bilis h\u00f3lyag szindr\u00f3ma \u00e9s a haemorrhagi\u00e1s cystitis pathogenesis\u00e9ben is.<\/jats:p>","DOI":"10.1556\/maseb.65.2012.4.3","type":"journal-article","created":{"date-parts":[[2012,9,2]],"date-time":"2012-09-02T07:41:39Z","timestamp":1346571699000},"page":"184-190","source":"Crossref","is-referenced-by-count":1,"title":["A h\u00fagyh\u00f3lyag gyullad\u00e1sos mikrokering\u00e9si reakci\u00f3inak k\u00eds\u00e9rletes vizsg\u00e1lata"],"prefix":"10.1556","volume":"65","author":[{"given":"P\u00e9ter","family":"J\u00e1romi","sequence":"first","affiliation":[{"name":"1 Urol\u00f3giai Oszt\u00e1ly, B\u00e1cs-Kiskun Megyei \u00d6nkorm\u00e1nyzat K\u00f3rh\u00e1za, Kecskem\u00e9t"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"2 Seb\u00e9szeti M\u0171t\u00e9ttani Int\u00e9zet, 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