{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:33:07Z","timestamp":1760783587124},"reference-count":19,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:title>Absztrakt<\/jats:title>\n        <jats:p>\n          <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Sz\u00e1mos k\u00f6zlem\u00e9ny \u00e9s saj\u00e1t adataink is azt mutatj\u00e1k, hogy tiszt\u00e1n in situ ductalis carcinoma (DCIS) eset\u00e9n nem javasolt a rutinszer\u0171 \u0151rszemnyirokcsom\u00f3-biopszia (SLNB). Ahhoz azonban, hogy elker\u00fclhess\u00fck a m\u00e1sodik m\u0171t\u00e9tet a specimen sz\u00f6vettani vizsg\u00e1lata sor\u00e1n \u00e9szlelt invaz\u00edv tumor miatt, preoperat\u00edve kell min\u00e9l nagyobb biztons\u00e1ggal meghat\u00e1rozni az inv\u00e1zi\u00f3 val\u00f3sz\u00edn\u0171s\u00e9g\u00e9t. Retrospekt\u00edv tanulm\u00e1nyunk c\u00e9lja a hengerbiopszia (CB) szenzitivit\u00e1s\u00e1nak vizsg\u00e1lata \u00e9s klinikai \u00e9s patol\u00f3giai faktorok predikt\u00edv \u00e9rt\u00e9k\u00e9nek meghat\u00e1roz\u00e1sa inv\u00e1zi\u00f3 vonatkoz\u00e1s\u00e1ban a mintav\u00e9tel sor\u00e1n tiszt\u00e1n DCIS-nek bizonyult eml\u0151daganatokban. <jats:italic>Anyag:<\/jats:italic> 2006. janu\u00e1r \u00e9s 2011. december k\u00f6z\u00f6tt 1311 esetben v\u00e9gezt\u00fcnk m\u0171t\u00e9tet eml\u0151 rosszindulat\u00fa daganata miatt, 50 esetben mutatott a preoperat\u00edv diagnosztika sor\u00e1n v\u00e9gzett CB DCIS-t. V\u00e9gleges sz\u00f6vettani vizsg\u00e1lat 17 (34,7%) esetben invaz\u00edv daganatot bizony\u00edtott, ennek el\u0151fordul\u00e1s\u00e1t vizsg\u00e1ltuk a betegek kora, a tumortest vagy microcalcificatio m\u00e9rete, a nukle\u00e1ris gradus, a comedonecrosis jelenl\u00e9te, illetve az \u00e9szlel\u00e9s m\u00f3dja (sz\u0171r\u00e9s vagy t\u00fcnetek alapj\u00e1n) f\u00fcggv\u00e9ny\u00e9ben. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> Azt tal\u00e1ltuk, hogy a sz\u0171r\u00e9sen kiemelt, t\u00fcnetmentes betegek eset\u00e9ben nagyobb es\u00e9llyel lesz a v\u00e9gleges diagn\u00f3zis DCIS, mint a m\u00e1r szimptomatikus (tapinthat\u00f3 csom\u00f3) esetekben (25\/32 vs. 7\/17). Ugyancsak \u00f6sszef\u00fcgg\u00e9st tal\u00e1ltunk a betegek kora \u00e9s az invazivit\u00e1s k\u00f6z\u00f6tt. 60 \u00e9vn\u00e9l fiatalabb betegek eset\u00e9ben l\u00e9nyegesen kisebb volt az invaz\u00edv daganat el\u0151fordul\u00e1sa, mint az enn\u00e9l id\u0151sebbekn\u00e9l (7\/32 vs. 10\/17). A\u00a0hengerbiopszia sor\u00e1n meghat\u00e1rozott tumorgradus szint\u00e9n el\u0151jelz\u0151je lehet az invazivit\u00e1snak, ugyanis adataink szerint a\u00a0magas gradus (G3) szignifik\u00e1nsan nagyobb val\u00f3sz\u00edn\u0171s\u00e9ggel jelez a v\u00e9gleges sz\u00f6vettani feldolgoz\u00e1skor tal\u00e1lt invaz\u00edv tumort, mint az alacsony (G1) vagy intermedier (G2) csoportban (3\/18 vs. 14\/31). <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic> Fentiek alapj\u00e1n nagyobb betegsz\u00e1mon v\u00e9gzett vizsg\u00e1latokkal pontosabban meghat\u00e1rozhat\u00f3 azon betegek k\u00f6re, akikn\u00e9l \u2013 b\u00e1r a henger-biopszia DCIS-t mutatott, az inv\u00e1zi\u00f3 fokozott es\u00e9lye miatt \u2013 egy \u00fcl\u00e9sben SLNB elv\u00e9gz\u00e9se is javasolt, azonban fenti esetekben rutinszer\u0171 axillaris staging nem indokolt.<\/jats:p>","DOI":"10.1556\/maseb.65.2012.4.8","type":"journal-article","created":{"date-parts":[[2012,9,2]],"date-time":"2012-09-02T07:41:39Z","timestamp":1346571699000},"page":"218-221","source":"Crossref","is-referenced-by-count":1,"title":["Az invazivit\u00e1s predikt\u00edv faktorai hengerbiopszi\u00e1val in situ ductalis carcinom\u00e1nak diagnosztiz\u00e1lt eml\u0151daganatokban"],"prefix":"10.1556","volume":"65","author":[{"given":"Csaba","family":"K\u00f3sa","sequence":"first","affiliation":[{"name":"1 Seb\u00e9szeti Int\u00e9zet, Debreceni Egyetem Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, 4012, Debrecen, M\u00f3ricz Zsigmond krt. 22."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Garami","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Int\u00e9zet, Debreceni Egyetem Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, 4012, Debrecen, M\u00f3ricz Zsigmond krt. 22."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Dinya","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Int\u00e9zet, Debreceni Egyetem Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, 4012, Debrecen, M\u00f3ricz Zsigmond krt. 22."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"1 Seb\u00e9szeti Int\u00e9zet, Debreceni Egyetem Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, 4012, Debrecen, M\u00f3ricz Zsigmond krt. 22."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1524-4741.2007.00525.x","article-title":"Value of sentinel lymph node biopsy in breast ductal carcinoma in situ upstaged to invasive carcinoma","volume":"14","author":"Sakr R","year":"2008","journal-title":"Breast J"},{"key":"2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/bjs.6162","article-title":"Meta-analysis of sentinel node biopsy in ductal carcinoma in situ of the breast","volume":"95","author":"Ansari B","year":"2008","journal-title":"British Journal of Surgery"},{"key":"3","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1056\/NEJMra031301","article-title":"Ductal Carcinoma in Situ of the Breast","volume":"350","author":"Burstein HJ","year":"2004","journal-title":"N Engl J Med"},{"key":"4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ejso.2007.08.003","article-title":"The value of sentinel lymph node biopsy in ductal carcinoma in situ (DCIS) and DCIS with microinvasion of the breast","volume":"34","author":"Parra RF","year":"2008","journal-title":"Eur J Surg Oncol"},{"key":"5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/SLA.0b013e31815b446b","article-title":"Sentinel node biopsy is not a standard procedure in ductal carcinoma in situ of the breast: the experience of the European institute of oncology on 854 patients in 10 years","volume":"247","author":"Intra M","year":"2008","journal-title":"Ann Surg"},{"key":"6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3816\/CBC.2005.n.023","article-title":"Sentinel lymph node biopsy in the management of ductal carcinoma in situ","volume":"6","author":"Zujewski J","year":"2005","journal-title":"Clin Breast Cancer"},{"key":"7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s005950200000","article-title":"Sentinel lymph node biopsy as a tool for the staging of ductal carcinoma in situ in patients with breast carcinoma","volume":"32","author":"Cserni G","year":"2002","journal-title":"Surg Today"},{"key":"8","first-page":"164","article-title":"\u0150rszemnyirokcsom\u00f3-biopszia in situ eml\u0151r\u00e1kban. 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