{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:32:17Z","timestamp":1776724337418,"version":"3.51.2"},"reference-count":39,"publisher":"Akademiai Kiado Zrt.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MaSeb"],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Absztrakt<\/jats:title>\n        <jats:p>\n          <jats:italic>Bevezet\u00e9s:<\/jats:italic> A nyaki elhelyezked\u00e9s\u0171 nyel\u0151cs\u0151laph\u00e1mr\u00e1k kritikus lokaliz\u00e1ci\u00f3j\u00fa, mert gyakran csak kiterjesztett m\u0171t\u00e9ttel t\u00e1vol\u00edthat\u00f3 el (laryngo-pharyngo-oesophagectomia). Az ut\u00f3bbi \u00e9vtizedben a neoadjuv\u00e1ns kemo-radioter\u00e1pia bevezet\u00e9se azonban hat\u00e1sosnak bizonyult az el\u0151rehaladott nyel\u0151cs\u0151laph\u00e1mr\u00e1kok kezel\u00e9s\u00e9ben. <jats:italic>Beteganyag \u00e9s m\u00f3dszer:<\/jats:italic> Klinik\u00e1nkon 1997 novembere \u00e9s 2012 janu\u00e1rja k\u00f6z\u00f6tt \u00f6sszesen 55 beteg r\u00e9szes\u00fclt preoperat\u00edv kemo-radioter\u00e1pi\u00e1ban lok\u00e1lisan el\u0151rehaladott, fels\u0151 harmadi nyel\u0151cs\u0151laph\u00e1mr\u00e1k miatt. A kezel\u00e9s sor\u00e1n 3960 cGy \u00f6sszd\u00f3zis\u00fa sug\u00e1rter\u00e1pi\u00e1t kaptak 180 cGy frakci\u00f3kban, valamint szimult\u00e1n Cisplatin \u00e9s 5-FU kemoter\u00e1pi\u00e1ban r\u00e9szes\u00fcltek. A kezel\u00e9st k\u00f6vet\u0151en 4\u20136 h\u00e9ttel az ism\u00e9telt vizsg\u00e1latok eredm\u00e9ny\u00e9t\u0151l f\u00fcgg\u0151en d\u00f6nt\u00f6tt\u00fcnk a m\u0171t\u00e9tr\u0151l. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A nyaki elhelyezked\u00e9s\u0171 nyel\u0151cs\u0151tumoros betegekn\u00e9l \u00f6sszesen 35 esetben (64%) v\u00e9gezt\u00fcnk nyel\u0151cs\u0151-resecti\u00f3t vagy laryngo-pharyngectomi\u00e1t. A m\u0171t\u00e9ti resecatum hisztopatol\u00f3giai vizsg\u00e1lata 16 betegn\u00e9l (16\/35, 46%) komplett remissi\u00f3t (pCR) igazolt. A perioperat\u00edv mortalit\u00e1sunk \u00e9s az anastomosisel\u00e9gtelens\u00e9g ugyanolyan sz\u00e1mban fordult el\u0151 5\/35 (14%). Az R0 resecti\u00f3k ar\u00e1nya 82% volt, a 2 \u00e9s 5 \u00e9ves t\u00fal\u00e9l\u00e9s 41%, illetve 18% lett. 19 esetben g\u00e9gemegtart\u00f3 pharyngo-oesophagectomi\u00e1t, 11 esetben laryngo-pharyngectomi\u00e1t v\u00e9gezt\u00fcnk, ut\u00f3bbi esetben a rekonstrukci\u00f3 szabad jejunum-transzplant\u00e1ci\u00f3val t\u00f6rt\u00e9nt. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> A magas ar\u00e1ny\u00fa pCR (46%) igazolja, hogy a fels\u0151 harmadi nyel\u0151cs\u0151tumorok jobban reag\u00e1lnak a multimod\u00e1lis kezel\u00e9sre. 30 esetben a neoadjuv\u00e1ns kezel\u00e9s eredm\u00e9nyezte tumorregressio lehet\u0151v\u00e9 tette a laryngo-pharyngo-oesophagectomia elker\u00fcl\u00e9s\u00e9t.<\/jats:p>","DOI":"10.1556\/maseb.65.2012.5.2","type":"journal-article","created":{"date-parts":[[2012,10,20]],"date-time":"2012-10-20T01:00:50Z","timestamp":1350694850000},"page":"340-347","source":"Crossref","is-referenced-by-count":2,"title":["A neoadjuv\u00e1ns kezel\u00e9s szerepe a nyaki szakaszon elhelyezked\u0151 el\u0151rehaladott nyel\u0151cs\u0151laph\u00e1mr\u00e1kok seb\u00e9szi kezel\u00e9s\u00e9ben"],"prefix":"10.1556","volume":"65","author":[{"given":"Andr\u00e1s","family":"Papp","sequence":"first","affiliation":[{"name":"1 Klinikai K\u00f6zpont, Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, 7624, P\u00e9cs, R\u00e1k\u00f3czi u. 2."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Cseke","sequence":"additional","affiliation":[{"name":"1 Klinikai K\u00f6zpont, Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, 7624, P\u00e9cs, R\u00e1k\u00f3czi u. 2."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Varga","sequence":"additional","affiliation":[{"name":"1 Klinikai K\u00f6zpont, Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, 7624, P\u00e9cs, R\u00e1k\u00f3czi u. 2."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Pavlovics","sequence":"additional","affiliation":[{"name":"1 Klinikai K\u00f6zpont, Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, 7624, P\u00e9cs, R\u00e1k\u00f3czi u. 2."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Pot\u00f3","sequence":"additional","affiliation":[{"name":"2 Bioanalitikai Int\u00e9zet, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, P\u00e9csi Tudom\u00e1nyegyetem, P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1ndor","family":"M\u00e1rton","sequence":"additional","affiliation":[{"name":"3 Klinikai K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00f3bert","family":"Farkas","sequence":"additional","affiliation":[{"name":"4 Klinikai K\u00f6zpont, Onkoter\u00e1pi\u00e1s Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"Bellyei","sequence":"additional","affiliation":[{"name":"4 Klinikai K\u00f6zpont, Onkoter\u00e1pi\u00e1s Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6rs P\u00e9ter","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"1 Klinikai K\u00f6zpont, Seb\u00e9szeti Klinika, P\u00e9csi Tudom\u00e1nyegyetem, 7624, P\u00e9cs, R\u00e1k\u00f3czi u. 2."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","volume-title":"Diseases of the esophagus","author":"Sorrentino P","year":"1988"},{"key":"2","first-page":"86","article-title":"Cervical and upper-third thoracic oesophageal carcinoma: a single pathological entity?","volume":"130","author":"Piessen G","year":"2005","journal-title":"Ann Chir"},{"key":"3","first-page":"317","article-title":"Surgical treatment of carcinoma of the hypopharynx and cervical oesophagus","volume":"9","author":"Lam KH","year":"1980","journal-title":"Ann Acad Med Singapore"},{"key":"4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1442-2050.2001.00163.x","article-title":"Current status of surgery for carcinoma of the hypopharynx and cervical esophagus","volume":"14","author":"Peracchia A","year":"2001","journal-title":"Dis Esophagus"},{"key":"5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/jso.20472","article-title":"A reappraisal of surgical management for squamous cell carcinoma in the pharyngoesophageal junction","volume":"93","author":"Wang HW","year":"2006","journal-title":"J Surg Oncol"},{"key":"6","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1001\/archsurg.136.10.1164","article-title":"Surgical management of carcinoma of the hypopharynx and cervical esophagus: analysis of 209 cases","volume":"136","author":"Triboulet JP","year":"2001","journal-title":"Arch Surg"},{"key":"7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF03218168","article-title":"A clinical study of surgical treatment of patients with carcinoma of the cervical esophagus extending to the thoracic esophagus","volume":"48","author":"Saito R","year":"2000","journal-title":"Jpn J Thorac Cardiovasc Surg"},{"key":"8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2739\/kurumemedj.39.183","article-title":"Questionable resection for carcinoma of the esophagus involving the trachea, bronchus and\/or aorta\u2013a comparative and multivariate analysis","volume":"39","author":"Fujita H","year":"1992","journal-title":"Kurume Med J"},{"key":"9","volume-title":"Clinical epidemiology","author":"Feinstein AR","year":"1985"},{"key":"10","first-page":"19","article-title":"A nyel\u0151cs\u0151r\u00e1kok neoadjuv\u00e1ns kezel\u00e9se","volume":"1","author":"Papp A","year":"2007","journal-title":"MOTESZ Magazin"},{"key":"11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1556\/MaSeb.60.2007.3.1","article-title":"A preoperat\u00edv kemo-radioter\u00e1pia hat\u00e1sa az el\u0151rehaladott fels\u0151 \u00e9s k\u00f6z\u00e9ps\u0151 harmadi nyel\u0151cs\u0151 laph\u00e1mr\u00e1kok kezel\u00e9s\u00e9ben","volume":"60","author":"Papp A","year":"2007","journal-title":"Magy Seb"},{"key":"12","first-page":"189","article-title":"A g\u00e9gemegtart\u00f3 pharyngo-oesophagectomia helye a pharyngo-oesophagealis \u00e1tmenet daganatainak seb\u00e9szi kezel\u00e9s\u00e9ben","volume":"53","author":"Horv\u00e1th \u00d6P","year":"2000","journal-title":"Magy Seb"},{"key":"13","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/S0003-4975(01)03167-8","article-title":"Larynx-preserving pharyngo-esophagectomy after chemoradiation in the treatment of cancer of the pharyngo-esophageal junction","volume":"72","author":"Horvath OP","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/micr.20216","article-title":"Esophagus reconstruction with free jejunal transfer","volume":"26","author":"Pavlovics G","year":"2006","journal-title":"Microsurgery"},{"key":"15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00000658-198708000-00011","article-title":"Esophagectomy without thoracotomy: is there a risk of intramediastinal bleeding? A study on blood supply of the esophagus","volume":"206","author":"Liebermann-Meffert DM","year":"1987","journal-title":"Ann Surg"},{"key":"16","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1200\/JCO.2005.00.034","article-title":"Chemoradiation with and whitout surgery in patients with locally advanced squamous cell carcinoma of the esophagus","volume":"23","author":"Stahl M","year":"2005","journal-title":"J Clin Oncol"},{"key":"17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1046\/j.0953-0673.2003.01722.x","article-title":"Gastrointestinal cancers in Europe","volume":"18","author":"Keighley MRB","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0960-7404(01)00027-5","article-title":"Cancer of the esophagus and gastro-esophageal junction: potentially curative therapies","volume":"10","author":"Lerut T","year":"2001","journal-title":"Surg Oncol"},{"key":"19","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00000658-200109000-00010","article-title":"Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1,000 consecutive resections at a single center in the Western world","volume":"234","author":"Siewert JR","year":"2001","journal-title":"Ann Surg"},{"key":"20","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0002-9610(03)00066-7","article-title":"A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer","volume":"185","author":"Urschel JD","year":"2003","journal-title":"Am J Surg"},{"key":"21","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1245\/ASO.2003.03.078","article-title":"Neoadjuvant treatment for resectable cancer of the esophagus and the gastroesophageal junction: a meta-analysis of randomized clinical trials","volume":"10","author":"Kaklamanos IG","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"22","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/gut.2003.025080","article-title":"Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis","volume":"53","author":"Fiorica F","year":"2004","journal-title":"Gut"},{"key":"23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.surg.2004.06.033","article-title":"Neoadjuvant chemoradiotherapy for esophageal carcinoma: a meta-analysis","volume":"137","author":"Greer SE","year":"2005","journal-title":"Surgery"},{"key":"24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S1470-2045(07)70039-6","article-title":"Australasian Gastro-Intestinal Trials Group. Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis","volume":"8","author":"Gebski V","year":"2007","journal-title":"Lancet Oncol"},{"key":"25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S1470-2045(07)70172-9","article-title":"Therapeutic strategies in oesophageal carcinoma: role of surgery and other modalities","volume":"8","author":"Mariette C","year":"2007","journal-title":"Lancet Oncol"},{"key":"26","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/bjs.4575","article-title":"Neoadjuvant therapy for oesophagogastric cancer","volume":"91","author":"Lordick F","year":"2004","journal-title":"Br J Surg"},{"key":"27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1200\/JCO.2001.19.2.305","article-title":"Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma","volume":"19","author":"Urba SG","year":"2001","journal-title":"J Clin Oncol"},{"key":"28","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1200\/JCO.2005.05.017","article-title":"Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival","volume":"23","author":"Berger AC","year":"2005","journal-title":"J Clin Oncol"},{"key":"29","first-page":"110","article-title":"Combined chemotherapy + radiotherapy + esophagectomy in squamous cell cancer of the esophagus","volume":"9","author":"Bidoli P","year":"1990","journal-title":"Proc Am Soc Clin Oncol"},{"key":"30","first-page":"297","article-title":"Total pharyngolaryngoesophagectomy. Indications and results apropos of 17 cases","volume":"46","author":"Borie D","year":"1992","journal-title":"Ann Chir"},{"key":"31","volume-title":"Recent advances in diseases of the esophagus","author":"Peracchia A","year":"1993"},{"key":"32","article-title":"Chemo-radiotherapy in Locally Advanced Squamous Cell Oesophageal Cancer-are Upper Third Tumours more Responsive?","author":"Papp A","year":"2009","journal-title":"Pathol Oncol Res"},{"key":"33","first-page":"1769","article-title":"Correlation between tumor-associated proteins and response to neoadjuvant treatment in patients with advanced squamous-cell esophageal cancer","volume":"31","author":"Farkas R","year":"2011","journal-title":"Anticancer Res"},{"key":"34","first-page":"130a","article-title":"Randomised phase III trial in locally advanced esophageal cancer: Radiochemotherapy followed by surgery versus radiochemotherapy alone (FFCD 9102)","volume":"21","author":"Bedenne L","year":"2002","journal-title":"Proc Am Soc Clin Oncol"},{"key":"35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/archotol.126.2.205","article-title":"Thirty-four patients with carcinoma of the cervical esophagus treated with chemoradiation therapy","volume":"126","author":"Burmeister B","year":"2000","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1442-2050.2001.00163.x","article-title":"Current status of surgery for carcinoma of the hypopharynx and cervical esophagus","volume":"14","author":"Peracchia A","year":"2001","journal-title":"Dis Esoph"},{"key":"37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1200\/JCO.1996.14.1.156","article-title":"Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma","volume":"14","author":"Bates BA","year":"1996","journal-title":"J Clin Oncol"},{"key":"38","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1010-7940(97)01194-9","article-title":"Induction therapy for clinical T4 oesophageal carcinoma; a plea for continued surgical exploration","volume":"11","author":"Raemdonck D","year":"1997","journal-title":"Eur J Cardiothorac Surg"},{"key":"39","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1245\/s10434-010-1314-7","article-title":"Improved outcomes in the management of esophageal cancer with the addition of surgical resection to chemoradiation therapy","volume":"18","author":"McKenzie S","year":"2011","journal-title":"Ann Surg Oncol"}],"container-title":["Magyar Seb\u00e9szet"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/1046\/65\/5\/article-p340.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/maseb.65.2012.5.2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:59:58Z","timestamp":1590141598000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/maseb.65.2012.5.2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,1]]},"references-count":39,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1556\/maseb.65.2012.5.2","relation":{},"ISSN":["0025-0295","1789-4301"],"issn-type":[{"value":"0025-0295","type":"print"},{"value":"1789-4301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,1]]}}}