{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T06:49:24Z","timestamp":1649054964223},"reference-count":15,"publisher":"Akademiai Kiado Zrt.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,1]]},"abstract":"<jats:p>\n          <jats:italic>Bevezet\u00e9s<\/jats:italic>\n : Minden betegs\u00e9g kezel\u00e9se sor\u00e1n el\u0151ny\u00f6s, ha az alkalmazott gy\u00f3gyszer koncentr\u00e1ci\u00f3ja a c\u00e9lszervben a legmagasabb. Ebb\u0151l k\u00f6vetkezik, hogy a k\u00f6t\u0151h\u00e1rtya betegs\u00e9geit, ha lehet, szemcseppekkel kezelj\u00fck. \n <jats:italic>C\u00e9lok:<\/jats:italic>\n Szerz\u0151 c\u00e9lja az emedastine hat\u00f3anyag\u00fa szemcsepp hat\u00e9konys\u00e1g\u00e1nak felm\u00e9r\u00e9se szezon\u00e1lis allergi\u00e1s k\u00f6t\u0151h\u00e1rtya-gyullad\u00e1sban szenved\u0151 gyermekeken. \n <jats:italic>M\u00f3dszer:<\/jats:italic>\n 2 vizsg\u00e1lat t\u00f6rt\u00e9nt. Az els\u0151 vizsg\u00e1lat sor\u00e1n 20 heveny szezon\u00e1lis allergi\u00e1s k\u00f6t\u0151h\u00e1rtya-gyullad\u00e1sban szenved\u0151 gyermekbeteg kapott emedastine difumarat (H\n <jats:sub>1<\/jats:sub>\n antihisztamin) tartalm\u00fa Emadine szemcseppet. K\u00f6t\u0151h\u00e1rty\u00e1juk v\u00e9rb\u0151s\u00e9g\u00e9t \u00e9s viszket\u0151 \u00e9rz\u00e9s\u00e9t 0-t\u00f3l 4-ig terjed\u0151 sk\u00e1l\u00e1n regisztr\u00e1lt\u00e1k, ahol 4 jelentette a legs\u00falyosabb t\u00fcneteket. A 2. vizsg\u00e1latban 232 m\u00e1sik gyermek kapta e szemcseppet 2 pollen szezonon kereszt\u00fcl \u00e9s vizsg\u00e1lt\u00e1k az esetleges hat\u00e1scs\u00f6kken\u00e9st \u00e9s mell\u00e9khat\u00e1sokat. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A k\u00f6t\u0151h\u00e1rtya viszket\u0151 \u00e9rzete \u00e1tlagosan 3, v\u00e9rb\u0151s\u00e9ge \u00e1tlagosan 8 perc alatt cs\u00f6kkent szignifik\u00e1ns m\u00e9rt\u00e9kben. A 2. vizsg\u00e1lat sor\u00e1n a 232 gyermek k\u00f6z\u00fcl egy sem k\u00e9nyszer\u00fclt a kezel\u00e9s m\u00f3dos\u00edt\u00e1s\u00e1ra hat\u00e1stalans\u00e1g, vagy valamilyen kellemetlen mell\u00e9khat\u00e1s miatt. \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n Az Emadine szemcsepp igen gyorsan \u00e9s hat\u00e9konyan cs\u00f6kkenti a k\u00f6t\u0151h\u00e1rtya-viszket\u00e9st \u00e9s -v\u00e9rb\u0151s\u00e9get. M\u00e1r 3 \u00e9ves kisgyermek is j\u00f3l t\u0171rte, \u00e9s tart\u00f3s haszn\u00e1lat eset\u00e9n sem cs\u00f6kkent a hat\u00e9konys\u00e1ga.<\/jats:p>","DOI":"10.1556\/oh.2007.27740","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T19:17:41Z","timestamp":1174936661000},"page":"251-254","source":"Crossref","is-referenced-by-count":1,"title":["The prompt effect of emedastine eye drop and the safety of its permanent use in children suffering from acute seasonal allergic conjunctivitis"],"prefix":"10.1556","volume":"148","author":[{"given":"L\u00e1szl\u00f3","family":"Endre","sequence":"first","affiliation":[{"name":"1 Orsz\u00e1gos Eg\u00e9szs\u00e9gfejleszt\u00e9si Int\u00e9zet Budapest VI. Andr\u00e1ssy \u00fat 82. 1062"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"77","volume":"6","year":"2003","journal-title":"Allergol. Klin. 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