{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T11:09:53Z","timestamp":1648724993767},"reference-count":14,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:p>\n          <jats:italic>Bevezet\u00e9s \u00e9s c\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n A szerz\u0151k a prosztatar\u00e1k, a leggyakoribb f\u00e9rfi malignus daganat diagnosztiz\u00e1l\u00e1s\u00e1t \u00e9s kezel\u00e9s\u00e9t vizsg\u00e1lt\u00e1k a prosztataspecifikus antig\u00e9n (PSA) klinikai bevezet\u00e9se \u00e9v\u00e9nek (1994) \u00e9s a 10 \u00e9vvel k\u00e9s\u0151bbi adatok \u00f6sszevet\u00e9s\u00e9vel. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n Az \u00e9vente v\u00e9gzett prosztatabiopszi\u00e1k sz\u00e1ma a vizsg\u00e1lt \u00e9vtized alatt 4,5-szeres\u00e9re n\u0151tt. 1994-ben a biopszi\u00e1k 36,2%-a, 2004-ben 47,5%-a bizonyult prosztatar\u00e1knak. A biopszi\u00e1zott betegek \u00e1tlag\u00e9letkora a vizsg\u00e1lt \u00e9vtized alatt 69,7 \u00e9vr\u0151l 62,3 \u00e9vre cs\u00f6kkent, de a prosztatar\u00e1kos betegek \u00e1tlag\u00e9letkora v\u00e1ltozatlan (70,8 vs. 71,3 \u00e9v). \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n 2004-ben a kor\u00e1bban m\u00e9rt teljes PSA-szint mellett az \u00fan. szabad PSA \u00e9s a PSA-denzit\u00e1s vizsg\u00e1lata is a diagn\u00f3zis r\u00e9sz\u00e9v\u00e9 v\u00e1lt, a prosztatabiopszi\u00e1kat transrectalis ultrahang-vez\u00e9relten, nem vakon \u00e9s perinealisan \u2013 mint kor\u00e1bban \u2013 v\u00e9gezt\u00e9k. Ennek k\u00f6sz\u00f6nhet\u0151en a prosztatabiopszi\u00e1k hat\u00e9konys\u00e1ga fokoz\u00f3dott, de jelen m\u00f3dszerekkel m\u00e9gsem siker\u00fclt a prosztatar\u00e1kot fiatalabb \u00e9letkorban felismerni. A diagnosztiz\u00e1lt prosztatar\u00e1kok Gleason-pontsz\u00e1mmal jellemezhet\u0151 malignit\u00e1sa cs\u00f6kkent, \u00edgy t\u00f6bb kurat\u00edv beavatkoz\u00e1sra alkalmas beteget \u00e9szleltek. Ugyanakkor a betegs\u00e9gspecifikus \u00e1tlagos prosztataspecifikus antig\u00e9n-\u00e9rt\u00e9k magas volta jelzi, hogy m\u00e9g mindig az el\u0151rehaladottabb (\u00e9s ez\u00e9rt csak palliat\u00edvan kezelhet\u0151) betegek vannak t\u00f6bbs\u00e9gben.<\/jats:p>","DOI":"10.1556\/oh.2007.27810","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T19:17:41Z","timestamp":1174936661000},"page":"121-124","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of prostate specific antigen in the first decade of its use, in our clinic (1994\u20132004)"],"prefix":"10.1556","volume":"148","author":[{"given":"Gergely","family":"B\u00e1nfi","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Urol\u00f3giai Klinika Budapest \u00dcll\u0151i \u00fat 78\/b. 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Glasz","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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