{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:58:26Z","timestamp":1761217106655},"reference-count":47,"publisher":"Akademiai Kiado Zrt.","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:p>A dehidroepiandroszteron \u00e9s szulfat\u00e1lt sz\u00e1rmaz\u00e9ka androg\u00e9n \u00e9s \u00f6sztrog\u00e9n hormonok el\u0151anyaga, a gon\u00e1dok szexu\u00e1lszteroid termel\u00e9s\u00e9hez j\u00e1rul hozz\u00e1. A dehidroepiandroszteron-szulf\u00e1t csak deszulfat\u00e1l\u00f3d\u00e1sa ut\u00e1n k\u00e9pes r\u00e9szt venni a folyamatban. A harmadik dek\u00e1dt\u00f3l kezdve a sz\u00e9rumszintj\u00fck fokozatosan cs\u00f6kken, id\u0151sebb korban a maxim\u00e1lis \u00e9rt\u00e9k csup\u00e1n 10\u201320%-a. Az alacsonyabb koncentr\u00e1ci\u00f3 k\u00fcl\u00f6nb\u00f6z\u0151 k\u00f3r\u00e1llapotokhoz vezethet, mint a csontritkul\u00e1s, a lipidmetabolizmus roml\u00e1sa, sz\u00edv-\u00e9rrendszeri betegs\u00e9gek, 2-es t\u00edpus\u00fa cukorbetegs\u00e9g. Autoimmun betegs\u00e9gben, szexu\u00e1lis diszfunkci\u00f3k eset\u00e9n szint\u00e9n alacsonyabb szintet tal\u00e1ltak. Az intrakrinol\u00f3gia az endokrinol\u00f3gia speci\u00e1lis \u00e1ga, jelent\u00e9se, hogy a hormonszint\u00e9zis \u00e9s hat\u00e1s ugyanazon sz\u00f6vetben, szekr\u00e9ci\u00f3 n\u00e9lk\u00fcl j\u00f6n l\u00e9tre. A magasabb helyi androg\u00e9n- \u00e9s\/vagy \u00f6sztrog\u00e9nkoncentr\u00e1ci\u00f3 a hirsutismus, acne, seborrhea, az eml\u0151 \u00e9s prosztatadaganatok patomechanizmus\u00e1ban jelent\u0151s t\u00e9nyez\u0151 lehet. A dehidroepiandroszteron-p\u00f3tl\u00e1s kedvez\u0151 hat\u00e1s\u00e1t l\u00e1tt\u00e1k posztmenopauz\u00e1s csontritkul\u00e1sban, lupus erythematosisban, pszichi\u00e1triai megbeteged\u00e9sekben, a lipid- \u00e9s sz\u00e9nhidr\u00e1t-anyagcser\u00e9ben \u00e9s szexu\u00e1lis diszfunkci\u00f3 eset\u00e9n. Cs\u00f6kkentette a zs\u00edrsz\u00f6vet mennyis\u00e9g\u00e9t. A szerz\u0151k a dehidroepiandroszteron \u00e9s szulfat\u00e1lt sz\u00e1rmaz\u00e9k\u00e1nak metabolizmus\u00e1t \u00e9s klinikai szerep\u00e9t mutatj\u00e1k be.<\/jats:p>","DOI":"10.1556\/oh.2007.27903","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T17:16:33Z","timestamp":1175706993000},"page":"651-657","source":"Crossref","is-referenced-by-count":9,"title":["Importance of dehydroepiandrosterone and dehydroepiandrosterone sulfate in different diseases"],"prefix":"10.1556","volume":"148","author":[{"given":"Kriszti\u00e1n","family":"B\u00e1csi","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Belgy\u00f3gy\u00e1szati Klinika Budapest Kor\u00e1nyi S. u 2\/a 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"K\u00f3sa","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. 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