{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T23:09:11Z","timestamp":1648940951189},"reference-count":12,"publisher":"Akademiai Kiado Zrt.","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:p>\n          <jats:italic>Bevezet\u00e9s:<\/jats:italic>\n Az ut\u00f3bbi \u00e9vekben felfedezett sz\u00e1mos \u00faj prognosztikai faktor seg\u00edts\u00e9get ny\u00fajthat a v\u00e1rhat\u00f3 t\u00fal\u00e9l\u00e9s meghat\u00e1roz\u00e1s\u00e1hoz kr\u00f3nikus lymphocyt\u00e1s leuk\u00e9mia eset\u00e9ben. \n <jats:italic>C\u00e9lok:<\/jats:italic>\n Jelen tanulm\u00e1ny c\u00e9lja e prognosztikai faktorok gyakoris\u00e1g\u00e1nak, valamint egym\u00e1ssal val\u00f3 \u00f6sszef\u00fcgg\u00e9s\u00e9nek meghat\u00e1roz\u00e1sa volt 419 beteg mint\u00e1in. \n <jats:italic>M\u00f3dszerek:<\/jats:italic>\n 160 esetben v\u00e9gezt\u00e9k el az immunglobulin-neh\u00e9zl\u00e1ncg\u00e9n mut\u00e1ci\u00f3s vizsg\u00e1lat\u00e1t. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n Az esetek 62%-\u00e1ban nem mut\u00e1lt immunglobulin g\u00e9nt tal\u00e1ltak, a neh\u00e9zl\u00e1nc g\u00e9ncsal\u00e1dok haszn\u00e1lata k\u00fcl\u00f6nb\u00f6z\u00f6tt a mut\u00e1ci\u00f3s st\u00e1tusz f\u00fcggv\u00e9ny\u00e9ben. A CD38 expresszi\u00f3 78%-os konkordanci\u00e1t mutatott a mut\u00e1ci\u00f3s st\u00e1tusszal, a ZAP-70-expresszi\u00f3 tekintet\u00e9ben korrel\u00e1ci\u00f3t nem figyeltek meg. Citogenetikai abnormalit\u00e1st 76%-ban l\u00e1ttak, a leggyakoribb elt\u00e9r\u00e9sek a del(13q) (57%), a 12-es trisz\u00f3mia (15%), a del(11q) (12%) \u00e9s a del(17p) (6%) voltak. A del(11q)-t hordoz\u00f3 esetek 95%-a nem mut\u00e1lt, az egyed\u00fcl del(13q)-t hordoz\u00f3 esetek 74%-a mut\u00e1lt IgH-g\u00e9nt tartalmazott. \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n A vizsg\u00e1lt param\u00e9terek nem f\u00fcggetlenek egym\u00e1st\u00f3l, ez\u00e9rt alkalmaz\u00e1suk a klinikai gyakorlatban gondos tervez\u00e9st ig\u00e9nyel.<\/jats:p>","DOI":"10.1556\/oh.2007.27943","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T18:32:49Z","timestamp":1176834769000},"page":"737-743","source":"Crossref","is-referenced-by-count":0,"title":["Complex analysis of prognostic factors in chronic lymphocytic leukemia"],"prefix":"10.1556","volume":"148","author":[{"given":"B\u00e9la","family":"Kajt\u00e1r","sequence":"first","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Patol\u00f3giai Int\u00e9zet P\u00e9cs Szigeti \u00fat 12. 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1l","family":"J\u00e1ks\u00f3","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Patol\u00f3giai Int\u00e9zet P\u00e9cs Szigeti \u00fat 12. 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Kereskai","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Patol\u00f3giai Int\u00e9zet P\u00e9cs Szigeti \u00fat 12. 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Lacza","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Patol\u00f3giai Int\u00e9zet P\u00e9cs Szigeti \u00fat 12. 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"M\u00e9hes","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Patol\u00f3giai Int\u00e9zet P\u00e9cs Szigeti \u00fat 12. 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ria","family":"Bodn\u00e1r","sequence":"additional","affiliation":[{"name":"2 Karolina K\u00f3rh\u00e1z Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Mosonmagyar\u00f3v\u00e1r"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Dombi J.","sequence":"additional","affiliation":[{"name":"3 Kom\u00e1rom-Esztergom Megyei \u00d6nkorm\u00e1nyzat Szent Borb\u00e1la K\u00f3rh\u00e1za II. 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