{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T10:24:56Z","timestamp":1648981496294},"reference-count":22,"publisher":"Akademiai Kiado Zrt.","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:p>A k\u00f6zponti idegrendszer \u00e9s az endokrin rendszer kapcsolata rendk\u00edv\u00fcl \u00f6sszetett. Az auton\u00f3m m\u0171k\u00f6d\u00e9seket a hypothalamus neuron\u00e1lis \u00e9s hormon\u00e1lis \u00faton integr\u00e1lja, biztos\u00edtja a szervezet homeoszt\u00e1zis\u00e1t, koordin\u00e1lja n\u00f6veked\u00e9si \u00e9s szaporod\u00e1si funkci\u00f3it, a stresszreakci\u00f3kat, az \u00e9lettani folyamatok ritmicit\u00e1s\u00e1t, periodicit\u00e1s\u00e1t \u00e9s id\u0151z\u00edt\u00e9s\u00e9t. Az \u00e1ltala termelt hormonok k\u00f6z\u00fcl az antidiuretikus hormonnak a j\u00f3l ismert hat\u00e1sain t\u00fal szerepe van a szoci\u00e1lis viselked\u00e9sben, mivel a vazopresszin-1A receptoron kereszt\u00fcl fokozza az agresszi\u00f3t. Az oxitocin az anyai viselked\u00e9s kialak\u00edt\u00e1sa mellett m\u00e1s szoci\u00e1lis interakci\u00f3kban, a p\u00e1rkapcsolati k\u00f6t\u0151d\u00e9sben, valamint az analgesi\u00e1ban \u00e9s a f\u00e1jdalom modul\u00e1l\u00e1s\u00e1ban j\u00e1tszik szerepet. A corticotrop-releasing hormon neurotranszmitterk\u00e9nt is m\u0171k\u00f6dik, kit\u00fcntetett szerepe van a stresszviselked\u00e9sben, szorong\u00e1sban \u00e9s depresszi\u00f3ban, er\u0151sen g\u00e1tolja a m\u00e9ly alv\u00e1st. Az ev\u00e9szavarok kialakul\u00e1s\u00e1ban a hypothalamus neurotranszmitterei \u00e9s neuropeptidjei k\u00f6z\u00fcl a szerotoninnak, noradrenalinnak, GABA-nak, kolecisztokininnek, neuropeptid Y-nak, Agouti-related proteinnek, \u03b1-melanocyta-stimul\u00e1l\u00f3 hormonnak \u00e9s ghrelinnek van alapvet\u0151 jelent\u0151s\u00e9ge, a leptin- \u00e9s galaninszintek hat\u00e1rozz\u00e1k meg, hogy anabolikus vagy katabolikus neurotranszmitterek k\u00e9pz\u0151djenek. A h\u0151szab\u00e1lyoz\u00e1sban a centr\u00e1lis termoreceptorok j\u00e1tszanak szerepet, a cirkadi\u00e1n ritmus\u00e9rt a nucleus suprachiasmaticus f\u0151k\u00e9nt \u201eid\u0151z\u00edt\u0151 g\u00e9neken\u201d kereszt\u00fcl felel\u0151s. A hypothalamicus k\u00f3rk\u00e9pek leggyakrabban bulimi\u00e1hoz vagy anorexi\u00e1hoz, hypersomni\u00e1hoz, impotenci\u00e1hoz, szorong\u00e1sos attakokhoz vezetnek. Leggyakoribb t\u00e9rsz\u0171k\u00edt\u0151 folyamata a craniopharyngeoma. A vazopresszin-elv\u00e1laszt\u00e1s hi\u00e1nya vagy cs\u00f6kken\u00e9se diabetes insipidust, m\u00edg a t\u00falzott mennyis\u00e9gben k\u00e9pz\u0151d\u0151 vazopresszin Schwartz\u2013Barter-szindr\u00f3m\u00e1t okoz. A Fr\u00f6hlich-, Kleine\u2013Levin- \u00e9s a Prader\u2013Willi-szindr\u00f3ma jellegzetes neuropszichi\u00e1triai elt\u00e9r\u00e9sekkel j\u00e1r. A hypophysis hipofunkci\u00f3 pszichi\u00e1triai k\u00e9p\u00e9t a demencia-del\u00edrium kombin\u00e1ci\u00f3 jellemzi, a hypophysis-adenom\u00e1k legjellegzetesebb neurol\u00f3giai t\u00fcnete a l\u00e1t\u00f3t\u00e9rkies\u00e9s. A somatotrop adenom\u00e1k okozta tipikus neurol\u00f3giai elt\u00e9r\u00e9sek a carpal tunnel-szindr\u00f3ma, az obstrukt\u00edv alv\u00e1si apnoe \u00e9s a fejf\u00e1j\u00e1s.<\/jats:p>","DOI":"10.1556\/oh.2007.27981","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T18:32:49Z","timestamp":1176834769000},"page":"723-730","source":"Crossref","is-referenced-by-count":2,"title":["Some neurological and psychiatric complications in the disorders of the hypothalamus and the pituitary gland"],"prefix":"10.1556","volume":"148","author":[{"given":"Zsuzsa","family":"Aszal\u00f3s","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"236","volume":"48","year":"1995","journal-title":"Clin. Neurosci.\/Ideggy. Szle."},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1469-7580.2005.00443.x","volume":"207","year":"2005","journal-title":"J. Anat."},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pbb.2006.01.001","volume":"83","year":"2006","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pain.2006.01.029","volume":"122","year":"2006","journal-title":"Pain"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.peptides.2004.02.002","volume":"25","year":"2004","journal-title":"Peptides"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000081785","volume":"80","year":"2004","journal-title":"Clinical Neuroendocrinology"},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1365-2796.2003.01175.x","volume":"254","year":"2003","journal-title":"J. Int. Med."},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/S0140-6736(01)06797-6","volume":"358","year":"2001","journal-title":"Lancet"},{"key":"atypb11","volume-title":"\u00c9lettan gy\u00f3gyszer\u00e9szhallgat\u00f3k r\u00e9sz\u00e9re","year":"2005"},{"key":"atypb12","first-page":"579","volume":"147","year":"2006","journal-title":"Orv. Hetil."},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.yhbeh.2006.03.010","volume":"50","year":"2006","journal-title":"Hormones and Behavior"},{"key":"atypb14","volume-title":"A pszichi\u00e1tria magyar k\u00e9zik\u00f6nyve","year":"2001"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.yhbeh.2005.12.011","volume":"49","year":"2006","journal-title":"Hormones and Behavior"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neulet.2005.12.071","volume":"398","year":"2006","journal-title":"Neuroscience Letters"},{"key":"atypb18","first-page":"47","volume":"75","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"atypb19","volume-title":"Endokrinol\u00f3gia","year":"2002"},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1474-4422(02)00191-6","volume":"1","year":"2002","journal-title":"Lancet Neurology"},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/S0140-6736(04)16413-1","volume":"363","year":"2004","journal-title":"Lancet"},{"key":"atypb22","first-page":"307","volume":"21","year":"2004","journal-title":"J. Clin. Neurophysiol."},{"key":"atypb23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.psyneuen.2006.01.005","volume":"31","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000050015","volume":"55","year":"2001","journal-title":"Hormone Research"},{"key":"atypb25","first-page":"1345","volume":"146","year":"2005","journal-title":"Orv. Hetil."}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/148\/16\/article-p723.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/148\/16\/article-p723.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T10:09:24Z","timestamp":1590574164000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/148\/16\/article-p723.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,1]]},"references-count":22,"journal-issue":{"issue":"16"},"URL":"https:\/\/doi.org\/10.1556\/oh.2007.27981","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,1]]}}}