{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:41:45Z","timestamp":1772084505391,"version":"3.50.1"},"reference-count":18,"publisher":"Akademiai Kiado Zrt.","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:p>Az asphyxi\u00e1t elszenvedett \u00fajsz\u00fcl\u00f6ttek kezel\u00e9s\u00e9ben \u00edg\u00e9retes lehet\u0151s\u00e9g a m\u00e9rs\u00e9kelt, teljestest-hypothermia, amely t\u00f6bb t\u00e1mad\u00e1sponton k\u00e9pes cs\u00f6kkenteni a hypoxia-ischaemia \u00e1ltal beind\u00edtott biok\u00e9miai kaszk\u00e1dot, valamint a maradand\u00f3 szervk\u00e1rosod\u00e1st. \n <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n A vizsg\u00e1lat c\u00e9lja az volt, hogy egy nagy esetsz\u00e1m\u00fa hat\u00e9konys\u00e1gi vizsg\u00e1latot megel\u0151z\u0151en felm\u00e9rje a m\u00e9rs\u00e9kelt teljestest-hypothermia biztons\u00e1goss\u00e1g\u00e1t \u00e9s technikai kivitelezhet\u0151s\u00e9g\u00e9t Magyarorsz\u00e1gon. \n <jats:italic>M\u00f3dszer:<\/jats:italic>\n Nyitott, prospekt\u00edv \u201eesetsorozat\u201d klinikai vizsg\u00e1lat keret\u00e9ben 2003 okt\u00f3ber\u00e9t\u0151l 2005 janu\u00e1rj\u00e1ig a Semmelweis Egyetem I. Gyermekgy\u00f3gy\u00e1szati Klinika NIC oszt\u00e1ly\u00e1n 28 \u00e9rett asphyxi\u00e1s \u00fajsz\u00fcl\u00f6ttn\u00e9l alkalmaztak hypothermi\u00e1s kezel\u00e9st, melyhez 23, kor\u00e1bban (1996 \u00e9s 2002 k\u00f6z\u00f6tti id\u0151szakban) kezelt, klinikai param\u00e9tereikben hasonl\u00f3 \u00fajsz\u00fcl\u00f6ttet v\u00e1lasztottak t\u00f6rt\u00e9nelmi kontrollk\u00e9nt. Bev\u00e1laszt\u00e1si krit\u00e9riumok: 5 perces Apgar-\u00e9rt\u00e9k: \u22645, emellett felv\u00e9telkor BE: \u2264 \u201315 mmol\/l \u00e9s hypoxi\u00e1s-ischaemi\u00e1s encephalopathi\u00e1ra jellemz\u0151 neurol\u00f3giai t\u00fcnetek jelenl\u00e9te egyidej\u0171leg. A m\u00e9rs\u00e9kelt, eg\u00e9sztest-hypothermi\u00e1t (magh\u0151: 33,0\u201334,0 \u00b0C) folyamatos morfin analg\u00e9zia mellett 72 \u00f3r\u00e1n kereszt\u00fcl tartott\u00e1k fenn. Az intenz\u00edv kezel\u00e9s alatt laborat\u00f3riumi vizsg\u00e1latok, szeri\u00e1lis koponya-UH, valamint standard intenz\u00edv ter\u00e1pi\u00e1s monitoroz\u00e1s t\u00f6rt\u00e9nt. A vizsg\u00e1lat sor\u00e1n \u00f6sszehasonl\u00edtott\u00e1k a mortalit\u00e1st, durva neurol\u00f3giai maradv\u00e1nyt\u00fcnetek el\u0151fordul\u00e1s\u00e1t, \u00e9s az el\u0151re meghat\u00e1rozott klinikai param\u00e9tereket. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A k\u00e9t csoport antropometriai adatai \u00e9s inici\u00e1lis klinikai \u00e1llapota (Apgar, pH, BE, encephalopathia t\u00fcnetei) szignifik\u00e1nsan nem k\u00fcl\u00f6nb\u00f6z\u00f6tt. A hypothermi\u00e1s (10\/28) \u00e9s a kontrollcsoport (10\/21) mortalit\u00e1s\u00e1ban nem tal\u00e1ltak k\u00fcl\u00f6nbs\u00e9get. A vizsg\u00e1lt klinikai param\u00e9terekben (laborat\u00f3riumi param\u00e9terek, ultrahang-elt\u00e9r\u00e9sek, hypoglykaemia, v\u00e9rz\u00e9kenys\u00e9g, s\u00falyos hipotenzi\u00f3 el\u0151fordul\u00e1sa, katecholamin-ig\u00e9ny, oliguria) \u00e9s a 1,5\u20132 \u00e9ves ut\u00e1nk\u00f6vet\u00e9s sor\u00e1n \u00e9szlelt idegrendszeri k\u00e1rosod\u00e1s ar\u00e1nyaiban szignifik\u00e1ns k\u00fcl\u00f6nbs\u00e9g nem igazol\u00f3dott. A hypothermi\u00e1val oki \u00f6sszef\u00fcgg\u00e9sbe hozhat\u00f3 mell\u00e9khat\u00e1st nem \u00e9szleltek. \n <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n A m\u00e9rs\u00e9kelt, eg\u00e9sztest-hypothermia a vizsg\u00e1lat szerint biztons\u00e1ggal alkalmazhat\u00f3, nem fokozza a s\u00falyos perinatalis asphyxi\u00e1t elszenvedett \u00fajsz\u00fcl\u00f6ttek mortalit\u00e1s\u00e1t \u00e9s morbidit\u00e1s\u00e1t. A hat\u00e1soss\u00e1g meg\u00edt\u00e9l\u00e9s\u00e9re tov\u00e1bbi, sz\u00e9les nemzetk\u00f6zi \u00f6sszefog\u00e1son alapul\u00f3 nagy esetsz\u00e1m\u00fa randomiz\u00e1lt klinikai vizsg\u00e1latra van sz\u00fcks\u00e9g.<\/jats:p>","DOI":"10.1556\/oh.2007.27985","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T15:18:30Z","timestamp":1179933510000},"page":"993-998","source":"Crossref","is-referenced-by-count":5,"title":["Whole body hypothermia for the treatment of hypoxic-ischaemic encephalopathy in term infants \u2013 a safety study in Hungary"],"prefix":"10.1556","volume":"148","author":[{"given":"Anik\u00f3","family":"R\u00f3ka","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. 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