{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:27:48Z","timestamp":1774686468193,"version":"3.50.1"},"reference-count":42,"publisher":"Akademiai Kiado Zrt.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,1]]},"abstract":"<jats:p>A pajzsmirigyhormonok alapvet\u0151 fontoss\u00e1g\u00faak a k\u00f6zponti idegrendszer perinat\u00e1lis fejl\u0151d\u00e9s\u00e9hez \u00e9s a feln\u0151tt agy m\u0171k\u00f6d\u00e9s\u00e9hez, els\u0151sorban a specifikus c\u00e9lg\u00e9nek transzkripci\u00f3j\u00e1nak szab\u00e1lyoz\u00e1s\u00e1val. Fokozz\u00e1k a kortik\u00e1lis szerotoninerg transzmisszi\u00f3t, szerepet j\u00e1tszanak a noradrenerg funkci\u00f3k szab\u00e1lyoz\u00e1s\u00e1ban, \u00e9s \u00e9rintik a GABA-funkci\u00f3t. A csecsem\u0151- \u00e9s kisgyermekkori hypothyreosis ment\u00e1lis retard\u00e1ci\u00f3hoz vezet, feln\u0151ttkorban a demencia \u00e9s a depresszi\u00f3 a leggyakoribb, de el\u0151fordulhat myxoedem\u00e1s k\u00f3ma, cerebellaris \u00e9s agyidegt\u00fcnetek, megn\u0151 a hajlam a cerebrovascularis k\u00f3rk\u00e9pekre. A perif\u00e9ria r\u00e9sz\u00e9r\u0151l polyneuropathia, carpalis alag\u00fat syndroma, myalgia gyakori; ritka sz\u00f6v\u0151dm\u00e9ny a myokymia. Csaknem minden hyperthyreotikus betegn\u00e9l el\u0151fordulnak minor pszichi\u00e1triai t\u00fcnetek, ritk\u00e1bban alakul ki pszich\u00f3zis, demencia, konf\u00fazi\u00f3s \u00e1llapot, depresszi\u00f3, ap\u00e1ti\u00e1s thyreotoxicosis, thyreotoxikus kr\u00edzis, epilepszia, pyramist\u00fcnetek vagy chorea. A perif\u00e9ria r\u00e9szv\u00e9tel\u00e9t kr\u00f3nikus thyreotoxikus myopathia, infiltrat\u00edv ophthalmomyopathia, myasthenia gravis, thyreotoxikus peri\u00f3dikus hypokalaemi\u00e1s b\u00e9nul\u00e1s \u00e9s polyneuropathia jelezheti. A figyelemhi\u00e1nyos hiperaktivit\u00e1sban szenved\u0151k jelent\u0151s r\u00e9sz\u00e9n\u00e9l generaliz\u00e1lt pajzsmirigyhormon-rezisztenci\u00e1t igazoltak. Magas antithyroid antitest titer jellemzi az akut-szubakut indul\u00e1s\u00fa, remisszi\u00f3kkal \u00e9s relapszusokkal jellemezhet\u0151, s\u00falyos, \u00e9letvesz\u00e9lyes, de szteroidra j\u00f3l reag\u00e1l\u00f3, autoimmun, ritk\u00e1n el\u0151fordul\u00f3 Hashimoto-encephalopathi\u00e1t.<\/jats:p>","DOI":"10.1556\/oh.2007.27988","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T19:17:41Z","timestamp":1174936661000},"page":"303-310","source":"Crossref","is-referenced-by-count":11,"title":["Some neurological and psychiatric complications in the disorders of the thyroid gland"],"prefix":"10.1556","volume":"148","author":[{"given":"Zsuzsa","family":"Aszal\u00f3s","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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