{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T15:14:37Z","timestamp":1721920477060},"reference-count":51,"publisher":"Akademiai Kiado Zrt.","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:p>\n          <jats:italic>C\u00e9kit\u0171z\u00e9s:<\/jats:italic>\n A vizsg\u00e1lat c\u00e9lja meghat\u00e1rozni a postmenopausalis hormonter\u00e1pia (kiz\u00e1r\u00f3lagos \u00f6sztrog\u00e9n-, szekvenci\u00e1lis \u00e9s folyamatosan kombin\u00e1lt \u00f6sztrog\u00e9n-progesztog\u00e9n kezel\u00e9s) hat\u00e1s\u00e1t az endometrialis v\u00e9rz\u00e9sre \u00e9s a m\u00e9hny\u00e1lkah\u00e1rtya sz\u00f6vettani \u00e1talakul\u00e1s\u00e1ra. \n <jats:italic>Beteganyag:<\/jats:italic>\n Szerz\u0151k klinik\u00e1j\u00e1nak Menopauza Ambulanci\u00e1j\u00e1n \u00f6t\u00e9ves id\u0151szakban (2000\u20132005) 5893 beteget gondoztak, \u00e9s vizsg\u00e1lt\u00e1k a postmenopausalis m\u00e9hv\u00e9rz\u00e9sek el\u0151fordul\u00e1s\u00e1t a hormonter\u00e1pi\u00e1ban r\u00e9szes\u00fcltek \u00e9s nem r\u00e9szes\u00fcltek csoportj\u00e1ban. V\u00e9rz\u00e9s eset\u00e9n mindig frakcion\u00e1lt abrasi\u00f3t v\u00e9geztek, \u00e9s a mint\u00e1kat sz\u00f6vettanilag feldolgozt\u00e1k. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A postmenopaus\u00e1ban l\u00e9v\u0151 betegek hormonkezel\u00e9sben nem r\u00e9szes\u00edtettek csoportj\u00e1ban t\u00f6bb mint k\u00e9tszer t\u00f6bb v\u00e9rz\u00e9s fordult el\u0151, mint a hormonkezel\u00e9sben r\u00e9szes\u00fcltek k\u00f6z\u00f6tt. Anyagukban a proliferati\u00f3s \u00e9s a hyperplasi\u00e1s endometrium-leletek els\u0151sorban a nem kezelt p\u00e1ciensek k\u00f6z\u00fcl ker\u00fcltek ki, ami amellett sz\u00f3l, hogy a megfelel\u0151 id\u0151ben, ak\u00e1r m\u00e1r a menopausa el\u0151tt megkezdett hormonkezel\u00e9s cs\u00f6kkentheti a hyperplasia \u00e9s ez\u00e1ltal k\u00f6zvetve az adenocarcinoma kialakul\u00e1s\u00e1nak az es\u00e9ly\u00e9t. A kiz\u00e1r\u00f3lag \u00f6sztrog\u00e9nt alkalmaz\u00f3 betegekben gyakoribb volt a hyperplasia. Elk\u00e9pzelhet\u0151nek tartj\u00e1k, hogy az ellens\u00falyozatlan \u00f6sztrog\u00e9nkezel\u00e9s a m\u00e1r megl\u00e9v\u0151 endometrium-hyperplasi\u00e1t tov\u00e1bb s\u00falyosb\u00edthatja. A hormonkezeltek csoportj\u00e1ban at\u00edpi\u00e1val j\u00e1r\u00f3 komplex hyperplasia nem, csak simplex hyperplasia fordult el\u0151. A folyamatosan kombin\u00e1lt k\u00e9sz\u00edtm\u00e9nyek alkalmaz\u00e1sa mellett az esetek d\u00f6nt\u0151 r\u00e9sz\u00e9ben a m\u00e9hny\u00e1lkah\u00e1rtya atr\u00f3fiz\u00e1l\u00f3dott, \u00edgy l\u00e9nyegesen cs\u00f6kkent a hyperplasi\u00e1val j\u00e1r\u00f3 elt\u00e9r\u00e9sek s a mell\u00e9khat\u00e1sk\u00e9nt jelentkez\u0151 v\u00e9rz\u00e9s es\u00e9lye. A hormonkezeltek k\u00f6z\u00f6tt gyakoribb volt az endometrium-polip, \u00e9s nem tudj\u00e1k megmagyar\u00e1zni, de a cervicalis polypusok ar\u00e1nya is. \n <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n A szerz\u0151k tapasztalata szerint a hormonkezel\u00e9s nem rizik\u00f3t\u00e9nyez\u0151je az endometrium-karcin\u00f3m\u00e1nak, hanem a kombin\u00e1lt k\u00e9sz\u00edtm\u00e9nyek a hyperplasia \u00e9s ezen kereszt\u00fcl az adenocarcinoma eredeti es\u00e9ly\u00e9t cs\u00f6kkentik.<\/jats:p>","DOI":"10.1556\/oh.2007.28000","type":"journal-article","created":{"date-parts":[[2007,10,8]],"date-time":"2007-10-08T15:34:45Z","timestamp":1191857685000},"page":"1451-1459","source":"Crossref","is-referenced-by-count":1,"title":["The effect of postmenopausal hormone replacement therapy on endometrial bleeding"],"prefix":"10.1556","volume":"148","author":[{"given":"Zolt\u00e1n","family":"Magyar","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Budapest Baross u. 27. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Csap\u00f3","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Budapest Baross u. 27. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Papp","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Budapest Baross u. 27. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"A sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szat tank\u00f6nyve","year":"2002"},{"key":"atypb2","first-page":"3537","volume":"80","year":"1995","journal-title":"J. Clin. 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