{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T01:08:58Z","timestamp":1747962538444},"reference-count":60,"publisher":"Akademiai Kiado Zrt.","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:p>Az epek\u0151betegs\u00e9gek kialakul\u00e1s\u00e1ban sz\u00e1mos g\u00e9n m\u0171k\u00f6d\u00e9s\u00e9t teszik felel\u0151ss\u00e9, melyek kapcsolatba hozhat\u00f3k els\u0151dlegesen a m\u00e1j betegs\u00e9geivel, az epeelfoly\u00e1si \u00e9s -k\u00e9pz\u0151d\u00e9si rendelleness\u00e9gekkel, a lipidmetabolizmus m\u00f3dosul\u00e1s\u00e1val, diabetes mellitussal, obesitassal, glutensensitiv enteropathi\u00e1val, Crohn-betegs\u00e9ggel, Down-szindr\u00f3m\u00e1val, Gaucher-k\u00f3rral, cysticus fibrosissal, valamint haematol\u00f3giai k\u00f3rk\u00e9pekkel \u00e9s ileumresectiot k\u00f6vet\u0151 \u00e1llapottal. Kialakul\u00e1s\u00e1ban szerepet j\u00e1tszanak gy\u00f3gyszermell\u00e9khat\u00e1sok, bakteri\u00e1lis fert\u0151z\u00e9sek, gyullad\u00e1sok, f\u00e9mionterhel\u00e9s \u00e9s szabadgy\u00f6k\u00f6s reakci\u00f3k. A zs\u00edrm\u00e1jb\u00f3l az ep\u00e9be tel\u00edtetlen zs\u00edrsavak, lipidoxidok, di\u00e9nkonjug\u00e1tumok, \u00e9s egy\u00e9b lipidperoxid\u00e1ci\u00f3s term\u00e9kek ker\u00fclnek, melyek az epevezet\u00e9kben \u00e9s a h\u00f3lyagban primer \u00e9s szekunder szabadgy\u00f6k\u00f6s folyamatokat ind\u00edtanak el. Az epeh\u00f3lyagfalban lej\u00e1tsz\u00f3d\u00f3 gyullad\u00e1sos folyamatok szabadgy\u00f6ktermel\u00e9ssel j\u00e1rnak. Az epe szabad bilirubin-tartalma koncentr\u00e1ci\u00f3f\u00fcgg\u0151en pro-, illetve antioxid\u00e1nsk\u00e9nt viselkedik. Az ambivalens tulajdons\u00e1g\u00fa szabad bilirubin, amely a mikrosz\u00f3m\u00e1k sziv\u00e1rg\u00e1sa r\u00e9v\u00e9n, illetve a b\u00e9l fel\u0151l a bakt\u00e9riumok degl\u00fckorinid\u00e1l\u00f3 hat\u00e1sa k\u00f6vetkezt\u00e9ben kimutathat\u00f3 mennyis\u00e9gben van jelen az epeh\u00f3lyagban, a szabadgy\u00f6k\u00f6s reakci\u00f3kat feler\u0151s\u00edti. A szabad bilirubin k\u0151alkot\u00f3 reakci\u00f3ja az ep\u00e9ben jelen l\u00e9v\u0151 f\u00e9mionokkal, els\u0151dlegesen a Ca<jats:sup>++<\/jats:sup>-ionokal kalcium-(hidrog\u00e9n)-bilirubin\u00e1tot eredm\u00e9nyez. A Ca<jats:sup>++<\/jats:sup>a zs\u00edrsavakkal is reakci\u00f3ba l\u00e9p, \u00e9s ezzel megv\u00e1ltoztatja az epe viszkozit\u00e1s\u00e1t. A lipidek, a szabad bilirubin \u00e9s a f\u00e9mionok egy\u00fcttesen k\u0151alkot\u00f3 komponensek. Az antioxid\u00e1nsok, illetve azok deriv\u00e1tumai vagy hat\u00e1sukban antioxid\u00e1ns tulajdons\u00e1got fokoz\u00f3 vegy\u00fcletek, k\u00e9sz\u00edtm\u00e9nyek t\u00f6bb szinten is kedvez\u0151en befoly\u00e1solhatj\u00e1k az epe \u00f6sszet\u00e9tel\u00e9t, illetve az epek\u0151k\u00e9pz\u0151d\u00e9s g\u00e1tl\u00e1s\u00e1t.<\/jats:p>","DOI":"10.1556\/oh.2007.28002","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T19:17:49Z","timestamp":1174936669000},"page":"589-596","source":"Crossref","is-referenced-by-count":5,"title":["Gallstone disease: Free radical reactions and the ambivalent role of bilirubin in the pathomechanism of gallstone formation"],"prefix":"10.1556","volume":"148","author":[{"given":"Anna","family":"Bl\u00e1zovics","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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