{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T09:34:59Z","timestamp":1648546499936},"reference-count":42,"publisher":"Akademiai Kiado Zrt.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,1]]},"abstract":"<jats:p>A kr\u00f3nikus veseel\u00e9gtelens\u00e9gben szenved\u0151, dial\u00edziskezel\u00e9sben r\u00e9szes\u00fcl\u0151 betegek k\u00f6r\u00e9ben \u00e1ltal\u00e1ban t\u00edzszer magasabb a hepatitis C-v\u00edrus el\u0151fordul\u00e1si ar\u00e1nya, mint a norm\u00e1l popul\u00e1ci\u00f3ban. N\u00e9h\u00e1ny betegben a v\u00edrus \u00e1ltal okozott kr\u00f3nikus glomerulonephritis \u00e1ll a h\u00e1tt\u00e9rben, de a betegek nagy r\u00e9sz\u00e9ben a m\u0171vesekezel\u00e9s sor\u00e1n szerzett nosocomi\u00e1lis fert\u0151z\u00e9sr\u0151l van sz\u00f3. A fert\u0151z\u00e9s csak a rendszeres sz\u0171r\u0151vizsg\u00e1latokkal fedezhet\u0151 fel biztons\u00e1gosan, mivel a legt\u00f6bb esetben a m\u00e1jenzimek norm\u00e1lisak. Ennek ellen\u00e9re a folyamat s\u00falyos m\u00e1jbetegs\u00e9gbe progredi\u00e1lhat. A dializ\u00e1lt betegek egy r\u00e9sze vesetranszplant\u00e1ci\u00f3ra v\u00e1r. A transzplant\u00e1ci\u00f3 ut\u00e1n adott immunszuppressz\u00edv kezel\u00e9s mellett azonban a v\u00edrus szaporod\u00e1sa jelent\u0151sen felgyorsul, mely a m\u00e1jbetegs\u00e9g roml\u00e1s\u00e1t id\u00e9zi el\u0151. A kil\u00f6k\u0151d\u00e9s vesz\u00e9lye miatt a transzplant\u00e1ci\u00f3 ut\u00e1n m\u00e1r nem kezelhet\u0151k interferonnal. Emiatt az alkalmas betegekben legk\u00e9s\u0151bb a m\u0171vesekezel\u00e9s id\u0151szak\u00e1ban kell a v\u00edrusellenes kezel\u00e9st elkezdeni. A besz\u0171k\u00fclt vesefunkci\u00f3j\u00fa betegekben kevesebb tapasztalat \u00e1ll rendelkez\u00e9sre. A legt\u00f6bb beteget interferonnal kezelt\u00e9k. Az interferon, a meglassult kiv\u00e1laszt\u00e1s miatt ugyan hat\u00e9konyabb, mint a norm\u00e1lis vesefunkci\u00f3 mellett, de a betegek kev\u00e9sb\u00e9 toler\u00e1lj\u00e1k. A ribavirin kiz\u00e1r\u00f3lag a ves\u00e9n kereszt\u00fcl v\u00e1laszt\u00f3dik ki, az anaemi\u00e1t okoz\u00f3 hat\u00e1sa m\u00e9g kifejezettebb ebben a betegcsoportban, ez\u00e9rt haszn\u00e1lata jelenleg nem elfogadott. A peginterferon alfa-2a a vesebetegek sz\u00e1m\u00e1ra igen kedvez\u0151 farmakokinetikai tulajdons\u00e1gokkal rendelkezik. Hat\u00e9konys\u00e1g\u00e1r\u00f3l egyre t\u00f6bb tanulm\u00e1ny \u00e1ll rendelkez\u00e9sre.<\/jats:p>","DOI":"10.1556\/oh.2007.28007","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T19:17:41Z","timestamp":1174936661000},"page":"489-494","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of patients with chronic hepatitis C before and after renal transplantation"],"prefix":"10.1556","volume":"148","author":[{"given":"Istv\u00e1n","family":"Tornai","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, Belgy\u00f3gy\u00e1szati Int\u00e9zet II. 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