{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T05:29:55Z","timestamp":1737005395646,"version":"3.33.0"},"reference-count":52,"publisher":"Akademiai Kiado Zrt.","issue":"Supplement-1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:p>A biol\u00f3giai ter\u00e1pia l\u00e9nyege, hogy a gyullad\u00e1s egyetlen, j\u00f3l meghat\u00e1rozott pontj\u00e1n (pl. egy adott citokin szintj\u00e9n) hat. Ez\u00e1ltal a sokszor igen bonyolult mechanizmusokb\u00f3l \u00e1ll\u00f3 patogenetikai h\u00e1l\u00f3zatot egy adott ponton szak\u00edtja meg. Ma a rheumatoid arthritis a biol\u00f3giai ter\u00e1pia szempontj\u00e1b\u00f3l modellbetegs\u00e9g, mivel a legt\u00f6bb szerrel ebben a k\u00f3rk\u00e9pben pr\u00f3b\u00e1lkoztak. Ezt k\u00f6vet\u0151en egy\u00e9b arthritisekben (pl. spondylitis ankylopoetica, psoriasisos arthropathia), majd egyes sziszt\u00e9m\u00e1s autoimmun k\u00f3rk\u00e9pekben (pl. sziszt\u00e9m\u00e1s lupus erythematosus, scleroderma, myositisek, vasculitisek, Sj\u00f6gren-szindr\u00f3ma stb.) kezdt\u00e9k el alkalmazni. A legt\u00f6bb k\u00f3rk\u00e9p eset\u00e9ben egy k\u00f6zponti szereppel b\u00edr\u00f3 citokin, a tumornekr\u00f3zis faktor-\u03b1 (TNF-\u03b1) g\u00e1tl\u00f3szerei \u00e1llnak a ter\u00e1pia k\u00f6z\u00e9ppontj\u00e1ban. Azonban a biol\u00f3giai ter\u00e1pia megtervez\u00e9sekor az adott k\u00f3rk\u00e9p patogenezis\u00e9t (pl. d\u00f6nt\u0151en Th1 vagy Th2 jelleg\u00e9t) figyelembe kell venni. Nem v\u00e9letlen, hogy am\u00edg egyes k\u00f3rk\u00e9pekben (pl. rheumatoid arthritis, spondylitis ankylopoetica, psoriasis, polymyositis, polyarticularis juvenilis arthritis) d\u00f6nt\u0151en a TNF-blokkol\u00f3k \u00e9s a T-sejtek elleni g\u00e1tl\u00e1s v\u00e1lt be, addig m\u00e1sokn\u00e1l (pl. lupus, Sj\u00f6gren-szindr\u00f3ma, dermatomyositis) a B-sejt elleni ter\u00e1pia kecsegtet sikerrel. Ezen \u00f6sszefoglal\u00f3ban a szerz\u0151k \u00e1ttekintik az arthritisek \u00e9s sziszt\u00e9m\u00e1s autoimmun k\u00f3rk\u00e9pek biol\u00f3giai ter\u00e1pi\u00e1j\u00e1ra vonatkoz\u00f3 legfontosabb adatokat. Kit\u00e9rnek az alkalmazott szerek tulajdons\u00e1gaira, a hat\u00e9konys\u00e1g \u00e9s biztons\u00e1goss\u00e1g k\u00e9rd\u00e9seire egyar\u00e1nt.<\/jats:p>","DOI":"10.1556\/oh.2007.28038","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T17:16:33Z","timestamp":1175706993000},"page":"63-70","source":"Crossref","is-referenced-by-count":5,"title":["Biological therapy of arthritis and systemic autoimmune diseases"],"prefix":"10.1556","volume":"148","author":[{"given":"L\u00e1szl\u00f3","family":"Tam\u00e1si","sequence":"first","affiliation":[{"name":"1 Szent Ferenc K\u00f3rh\u00e1z Reumatol\u00f3giai Oszt\u00e1ly Miskolc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Szekanecz","sequence":"additional","affiliation":[{"name":"2 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum Belgy\u00f3gy\u00e1szati Int\u00e9zet, III. sz. Belgy\u00f3gy\u00e1szati Klinika, Reumatol\u00f3giai Tansz\u00e9k Debrecen M\u00f3ricz Zs. krt. 22. 4004"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/01.bor.0000159926.42761.dd","volume":"17","year":"2005","journal-title":"Curr. Opin. Rheumatol."},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.berh.2005.05.006","volume":"19","year":"2005","journal-title":"Best Parct. Res. Clin. 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