{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:08:55Z","timestamp":1765231735624},"reference-count":27,"publisher":"Akademiai Kiado Zrt.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:p>A neonatalis lupus erythematosus (NLE) az \u00fajsz\u00fcl\u00f6ttek els\u0151 n\u00e9h\u00e1ny h\u00f3napj\u00e1nak megbeteged\u00e9se, melyet az \u00e9desanya autoimmun betegs\u00e9g\u00e9nek (SLE, Sj\u00f6gren, rheumatoid arthritis stb.) kapcs\u00e1n termel\u0151d\u0151, placent\u00e1n \u00e1tjut\u00f3 anti-SSA- \u00e9s anti-SSB-ellenanyagok okoznak. Ritka megbeteged\u00e9s. T\u00fcnetei \u00e9rinthetik a b\u0151rt (jellegzetes annul\u00e1ris, erythem\u00e1s plakkok), a sz\u00edvet, a m\u00e1jat \u00e9s a v\u00e9rk\u00e9pz\u00e9st. Legs\u00falyosabb k\u00f6vetkezm\u00e9nye a 20\u201330%-os mortalit\u00e1s\u00e9rt els\u0151sorban felel\u0151s III. fok\u00fa AV-blokk, mely maradand\u00f3 k\u00e1rosod\u00e1s, s pacemaker be\u00fcltet\u00e9s\u00e9t teszi sz\u00fcks\u00e9gess\u00e9. A t\u00fcnetek \u00e1ltal\u00e1ban kezel\u00e9s n\u00e9lk\u00fcl megsz\u0171nnek az anyai ellenanyagok ki\u00fcr\u00fcl\u00e9s\u00e9vel p\u00e1rhuzamosan a csecsem\u0151 6\u20139 h\u00f3napos kor\u00e1ra. Eset\u00fcnkben a tipikus b\u0151rt\u00fcnetek az eg\u00e9sz testet \u00e9rintett\u00e9k, m\u00e1r sz\u00fclet\u00e9skor fenn\u00e1lltak, de sz\u00edvblokk nem alakult ki. A diagn\u00f3zist jelent\u0151sen nehez\u00edtette, hogy az \u00e9desanya betegs\u00e9ge nem volt ismert a sz\u00fcl\u00e9s idej\u00e9n. A jelent\u0151s thrombocytopenia, progredi\u00e1l\u00f3 b\u0151rt\u00fcnetek \u00e9s emelkedett m\u00e1jfunkci\u00f3s \u00e9rt\u00e9kek miatt sziszt\u00e9m\u00e1s szteroid ad\u00e1s\u00e1ra k\u00e9nyszer\u00fclt\u00fcnk.<\/jats:p>","DOI":"10.1556\/oh.2007.28058","type":"journal-article","created":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T11:52:11Z","timestamp":1192794731000},"page":"2051-2055","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal lupus erythematosus: case report and review of the literature"],"prefix":"10.1556","volume":"148","author":[{"given":"G\u00e9za","family":"Vass","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. 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