{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:28:40Z","timestamp":1773307720238,"version":"3.50.1"},"reference-count":45,"publisher":"Akademiai Kiado Zrt.","issue":"39","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:p>A testt\u00f6meg, ezen bel\u00fcl a zs\u00edrt\u00f6meg regul\u00e1l\u00e1sa egy visszacsatol\u00e1sos rendszerben val\u00f3sul meg, melyben a zs\u00edrt\u00f6meg nagys\u00e1g\u00e1r\u00f3l adipositasszign\u00e1lok (leptin, inzulin, amylin), a pillanatnyi t\u00e1pl\u00e1lts\u00e1gi \u00e1llapotr\u00f3l intestinalis peptidhormonok (ghrelin, PYY, PP, GLP-1, OXM, CCK) \u00e9s a n. vagus inform\u00e1lj\u00e1k a k\u00f6zponti idegrendszert mint k\u00f6zponti szab\u00e1lyoz\u00f3t. A hypothalamus nucleus arcuatus\u00e1nak k\u00e9t j\u00f3l elk\u00fcl\u00f6n\u00edthet\u0151 neuroncsoportja fogadja a zs\u00edrt\u00f6meg nagys\u00e1g\u00e1val ar\u00e1nyos mennyis\u00e9gben termel\u0151d\u0151 leptin k\u00f6zvet\u00edtette afferens inform\u00e1ci\u00f3t. A leptink\u00f6t\u0151d\u00e9s a sejtek felsz\u00edn\u00e9n elhelyezked\u0151 leptinreceptorokhoz intracellul\u00e1ris szign\u00e1lmechanizmusokon kereszt\u00fcl a targetg\u00e9nek aktiv\u00e1l\u00f3d\u00e1s\u00e1t \u00e9s anorexig\u00e9n (POMC, CART) neuropeptidek termel\u00e9s\u00e9t, majd m\u00e1sodlagos k\u00f6zpontokon kereszt\u00fcl az energiafelv\u00e9tel \u00e9s -lead\u00e1s folyamatainak efferens regul\u00e1ci\u00f3s mechanizmusait gener\u00e1lja. A testt\u00f6meg-szab\u00e1lyoz\u00e1s \u00f6sszetett \u00e9s redund\u00e1ns rendszer, sz\u00e1mos m\u00e1s neuroendokrin folyamattal (n\u00f6veked\u00e9s, mell\u00e9kvese- \u00e9s pajzsmirigym\u0171k\u00f6d\u00e9s, reprodukt\u00edv funkci\u00f3k stb.), mem\u00f3ria-, valamint jutalmaz\u00e1si \u00e9s f\u00fcgg\u0151s\u00e9gi mechanizmussal \u00e1ll kapcsolatban, \u00edgy a szab\u00e1lyoz\u00f3rendszer egyes elemeinek befoly\u00e1sol\u00e1sa, pl. gy\u00f3gyszerekkel, m\u00e1s rendszerek m\u0171k\u00f6d\u00e9s\u00e9re is hat\u00e1ssal lehet, mell\u00e9khat\u00e1sok fell\u00e9pt\u00e9re lehet sz\u00e1m\u00edtani. Az obesitas vil\u00e1gm\u00e9ret\u0171 epid\u00e9mi\u00e1ja \u2013 mely els\u0151sorban a magas energias\u0171r\u0171s\u00e9g\u0171 \u00e9lelmiszerek b\u0151s\u00e9g\u00e9vel \u00e9s a mozg\u00e1sszeg\u00e9ny \u00e9letm\u00f3ddal \u00e1ll \u00f6sszef\u00fcgg\u00e9sben, melyhez a testt\u00f6meg-szab\u00e1lyoz\u00f3 rendszer\u00fcnk nem tud megfelel\u0151en alkalmazkodni \u2013 intenz\u00edv kutat\u00e1sokra \u00f6szt\u00f6nzi az akad\u00e9miai \u00e9s gy\u00f3gyszeripari kutat\u00f3k\u00f6zpontokat annak \u00e9rdek\u00e9ben, hogy \u00faj gy\u00f3gyszerek, hat\u00e9kony tests\u00falycs\u00f6kkent\u0151 kezel\u00e9si elj\u00e1r\u00e1sok \u00e1lljanak rendelkez\u00e9sre az \u00e9letm\u00f3d-v\u00e1ltoztat\u00e1si strat\u00e9gi\u00e1kon (di\u00e9ta, fizikai aktivit\u00e1s, magatart\u00e1ster\u00e1pia) t\u00falmen\u0151en.<\/jats:p>","DOI":"10.1556\/oh.2007.28085","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T14:48:56Z","timestamp":1190731736000},"page":"1827-1836","source":"Crossref","is-referenced-by-count":4,"title":["The regulation of body mass and its relation to the development of obesity"],"prefix":"10.1556","volume":"148","author":[{"given":"Attila","family":"Juh\u00e1sz","sequence":"first","affiliation":[{"name":"1 Sopron MJV Erzs\u00e9bet K\u00f3rh\u00e1z, a DE OEC Oktat\u00f3 K\u00f3rh\u00e1za Belgy\u00f3gy\u00e1szat Sopron Gy\u0151ri \u00fat 15. 9400"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelin","family":"Katona","sequence":"additional","affiliation":[{"name":"2 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum Belgy\u00f3gy\u00e1szati Int\u00e9zet, I. sz. 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