{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:20:25Z","timestamp":1698643225672},"reference-count":14,"publisher":"Akademiai Kiado Zrt.","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:p>Az 1-es t\u00edpus\u00fa cukorbetegs\u00e9g gyakran t\u00e1rsul egy\u00e9b autoimmun k\u00f3rk\u00e9pekkel. A parietalis sejtellenes antitestek (PCA), melyek az 1-es t\u00edpus\u00fa cukorbetegek mintegy 20%-\u00e1ban megtal\u00e1lhat\u00f3k, autoimmun gastritis \u00e9s anaemia perniciosa jelenl\u00e9t\u00e9re figyelmeztetnek. A PCA-k a gyomor-H\n <jats:sup>+<\/jats:sup>\n \/K\n <jats:sup>+<\/jats:sup>\n ATP-\u00e1zt k\u00e1ros\u00edtj\u00e1k, \u00e9s hypo-\/achlorhydri\u00e1t, hypergastrinaemi\u00e1t okozhatnak. Ennek k\u00f6vetkezt\u00e9ben az enterochromaffin-szer\u0171 (ECL) sejtek hyper-\/dysplasiaja alakulhat ki, mely carcinoid gyomortumor kialakul\u00e1s\u00e1ra hajlamos\u00edt. Az ECL-sejtek hyperplasi\u00e1j\u00e1b\u00f3l fejl\u0151d\u0151 gyomorcarcinoidok az autoimmun gastritises vagy anaemia pernicios\u00e1ban szenved\u0151 betegek 4\u20139%-\u00e1ban alakulnak ki. A 29 \u00e9ves, 6 \u00e9ve 1-es t\u00edpus\u00fa diab\u00e9teszben szenved\u0151, 8 \u00e9ves kora \u00f3ta primer hypothyreosis miatt pajzsmirigyhormon-szubsztit\u00faci\u00f3ban r\u00e9szes\u00fcl\u0151 n\u0151beteg\u00fcnkn\u00e9l gyomorpanaszok miatt fels\u0151 panendoszk\u00f3pia \u00e9s biopszi\u00e1s vizsg\u00e1lat t\u00f6rt\u00e9nt. Az endoszk\u00f3pia t\u00f6bbsz\u00f6r\u00f6s kicsi polipokat mutatott a fundus ter\u00fclet\u00e9n nonantral hypergastrinaemi\u00e1s (A-t\u00edpus\u00fa) atrophi\u00e1s gastritissel. A parietalis sejtantitest-vizsg\u00e1lat pozit\u00edv volt, a sz\u00e9rum-chromogranin-A koncentr\u00e1ci\u00f3ja (CgA) 289,7 ng\/ml (norm: 98 ng\/ml alatt), a TSH-szint 9,93 mIU\/L volt. A sz\u00f6vettani vizsg\u00e1lat carcinoid tumort igazolt. Octreotidter\u00e1pi\u00e1t k\u00f6vet\u0151en parci\u00e1lis gastrectomi\u00e1t v\u00e9geztek. M\u0171t\u00e9t ut\u00e1n a sz\u00e9rum-chromogranin-A-szint normaliz\u00e1l\u00f3dott. A nonatral, t\u00f6bbsz\u00f6r\u00f6s polipok n\u00e9ma neuroendocrin tumort takarhatnak, melyek rendszerint lassan n\u00f6vekv\u0151, benignus viselked\u00e9s\u0171 endokrin daganatok, de magas malignit\u00e1s\u00fa endokrin karcin\u00f3m\u00e1k is lehetnek. A specifikus sz\u00e9rum- vagy sz\u00f6veti chromogranin-A (CgA) \u00e9s egy\u00e9b endokrin tumorra utal\u00f3 markerek m\u00e9r\u00e9s\u00e9nek el\u00e9rhet\u0151v\u00e9 v\u00e1l\u00e1s\u00e1val e tumorok k\u00f6nnyen felismerhet\u0151k lehetnek a klinikus sz\u00e1m\u00e1ra.<\/jats:p>","DOI":"10.1556\/oh.2007.28100","type":"journal-article","created":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T15:55:54Z","timestamp":1188316554000},"page":"1667-1671","source":"Crossref","is-referenced-by-count":4,"title":["Development of silent gastric carcinoid in a type 1 diabetic patient with primer hypothyreosis"],"prefix":"10.1556","volume":"148","author":[{"given":"Anik\u00f3","family":"Somogyi","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Ruzicska","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timea","family":"Varga","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1roly","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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