{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T18:02:28Z","timestamp":1649008948463},"reference-count":48,"publisher":"Akademiai Kiado Zrt.","issue":"33","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:p>A szerz\u0151 \u00f6sszefoglalja a funkcion\u00e1lis dyspepsia fogalm\u00e1nak t\u00f6rt\u00e9neti kialakul\u00e1s\u00e1t, majd \u00e1ttekinti az \u00fan. r\u00f3mai folyamatot: 1988\u20132006 k\u00f6z\u00f6tt szak\u00e9rt\u0151i csoportok az \u00fan. \n <jats:italic>Delphi<\/jats:italic>\n -m\u00f3dszerrel kidolgozt\u00e1k a funkcion\u00e1lis gastrointestinalis k\u00f3rk\u00e9pek R\u00f3ma I, II \u00e9s III oszt\u00e1lyoz\u00e1s\u00e1t. A R\u00f3ma III oszt\u00e1lyoz\u00e1s \u00fajrafogalmazta a funkcion\u00e1lis dyspepsia meghat\u00e1roz\u00e1s\u00e1t, \u00e9s azt a postprandialis distress \u00e9s epigastrialis f\u00e1jdalomszindr\u00f3ma alcsoportokba sorolta. Epidemiol\u00f3giai adatok alapj\u00e1n a dyspepsia mint k\u00f3rh\u00e1zi felv\u00e9telt ig\u00e9nyl\u0151 betegs\u00e9g az 1730-as \u00e9vekben jelent meg, \u00e9s n\u00e9h\u00e1ny \u00e9vtized alatt el\u00e9rte a prevalencia mai sz\u00ednvonal\u00e1t, amely jelenleg 7\u201345% k\u00f6z\u00f6tt van, \u00e9s f\u00f6ldrajzi r\u00e9gi\u00f3k szerint v\u00e1ltozik. A funkcion\u00e1lis dyspepsia etiopatogen\u00e9zis\u00e9ben a \n <jats:italic>Helicobacter pylori<\/jats:italic>\n - \u00e9s a \n <jats:italic>Salmonella<\/jats:italic>\n -fert\u0151z\u00e9s szerepe mellett a HCl-termel\u00e9s k\u00f3ros fenot\u00edpus\u00e1nak, a motilit\u00e1szavaroknak (akkomod\u00e1ci\u00f3, gyomor\u00fcr\u00fcl\u00e9si zavar), a gyomor hiperszenzitivit\u00e1s\u00e1nak \u00e9s hormon\u00e1lis elv\u00e1ltoz\u00e1soknak lehet szerepe, de egyik elt\u00e9r\u00e9s sem jellemz\u0151 a dyspepsia minden form\u00e1j\u00e1ra. Felmer\u00fclt az alfa-adrenoreceptorok szint\u00e9zis\u00e9t szab\u00e1lyoz\u00f3 g\u00e9nek polimorfizmus\u00e1nak szerepe is. A funkcion\u00e1lis dyspepsia kezel\u00e9s\u00e9ben az eredm\u00e9nyek nem v\u00e1ltott\u00e1k be a rem\u00e9nyeket, \u00e9s azok nehezen \u00e9rtelmezhet\u0151k a placebohat\u00e1s magas ar\u00e1nya miatt. Az ut\u00f3bbi \u00e9vek metaanal\u00edzisei szerint a protonpumpag\u00e1tl\u00f3k \u00e9s H\n <jats:sub>2<\/jats:sub>\n -receptor-blokkol\u00f3k hat\u00e1sa jobb, mint a placeb\u00f3\u00e9. A cisaprid hat\u00e1sos volt, de 2004-ben visszavont\u00e1k. A \n <jats:italic>Helicobacter pylori<\/jats:italic>\n -eradik\u00e1ci\u00f3 t\u00fcnetileg csak az esetek egy r\u00e9sz\u00e9ben hat\u00e1sos, de a kezel\u00e9st a peptikus fek\u00e9ly \u00e9s gyomorkarcin\u00f3ma megel\u0151z\u00e9se c\u00e9lj\u00e1b\u00f3l, valamint k\u00f6zeg\u00e9szs\u00e9g\u00fcgyi szempontb\u00f3l el kell v\u00e9gezni \n <jats:italic>test-and-treat<\/jats:italic>\n vagy \n <jats:italic>scope-and-treat<\/jats:italic>\n strat\u00e9gia szerint. A fenti kezel\u00e9sek hat\u00e1sa \u00e1tmeneti, javul\u00e1s ut\u00e1n a panaszok a k\u00f6vet\u00e9s eddigi 5\u20137 \u00e9ve alatt v\u00e1ltoz\u00f3 intenzit\u00e1ssal az esetek 50%-\u00e1ban visszat\u00e9rnek. A R\u00f3ma III oszt\u00e1lyoz\u00e1s c\u00e9lja, hogy az \u00faj kutat\u00e1sok alapj\u00e1n a funkcion\u00e1lis dyspepsi\u00e1t okoz\u00f3 k\u00f3r\u00e9lettani t\u00e9nyez\u0151ket azonos\u00edtsa, \u00e9s azok c\u00e9lzott kezel\u00e9s\u00e9vel az eddigiekn\u00e9l jobb, k\u00f6lts\u00e9ghat\u00e9kony eredm\u00e9nyeket \u00e9rjen el.<\/jats:p>","DOI":"10.1556\/oh.2007.28131","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T19:14:00Z","timestamp":1187118840000},"page":"1573-1579","source":"Crossref","is-referenced-by-count":3,"title":["Functional dyspepsia: the past, the present and the Rome III classification"],"prefix":"10.1556","volume":"148","author":[{"given":"Gy\u00f6rgy Mikl\u00f3s","family":"Buz\u00e1s","sequence":"first","affiliation":[{"name":"1 Ferencv\u00e1rosi Eg\u00e9szs\u00e9g\u00fcgyi Szolg\u00e1lat Gasztroenterol\u00f3gia Budapest Mester u. 45. 1095"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb3","volume-title":"Gastroenterology in Britain","year":"1997"},{"key":"atypb4","volume-title":"Gastroenterology in Britain","year":"1997"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"614","DOI":"10.5694\/j.1326-5377.1986.tb139512.x","volume":"145","year":"1986","journal-title":"Med. 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