{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T20:08:24Z","timestamp":1649016504126},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"41","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:p>A neuroakt\u00edv szteroid b\u00e1rmely szervben k\u00e9pz\u0151dik, m\u00f3dos\u00edtani k\u00e9pes a neur\u00e1lis aktivit\u00e1st k\u00fcl\u00f6nb\u00f6z\u0151 membr\u00e1nreceptorok modul\u00e1l\u00e1sa \u00fatj\u00e1n. A neuroszteroid de novo a neuronban \u00e9s gli\u00e1ban szintetiz\u00e1l\u00f3dik, a k\u00f6zponti idegrendszerben megtal\u00e1lhat\u00f3k a szteroidk\u00e9pz\u0151 enzimek. A citoplazm\u00e1ban klasszikus, genomikus \u00faton szab\u00e1lyz\u00f3, hossz\u00fa idej\u0171 hat\u00e1sokat kiv\u00e1lt\u00f3 szteroidhormon-receptorok vannak, a membr\u00e1nban r\u00f6vid id\u0151tartam\u00fa, nem klasszikus szteroidreceptorok. L\u00e9nyeges szerepet j\u00e1tszanak a szteroidreceptorokkal interfer\u00e1l\u00f3 vagy az aktivit\u00e1sukat fokoz\u00f3 korepresszorok \u00e9s koaktiv\u00e1torok. A kortikoszteroidok a stresszben bet\u00f6lt\u00f6tt funkci\u00f3jukon t\u00fal bizony\u00edtott szerepet j\u00e1tszanak a f\u00e9lelemben, szorong\u00e1sban \u00e9s mem\u00f3riafunkci\u00f3kban, \u00edgy Cushing-szindr\u00f3m\u00e1ban gyakran fordul el\u0151 hangulatzavar, reverz\u00edbilis cerebr\u00e1lis atr\u00f3fia a kognit\u00edv funkci\u00f3k \u00e1tmeneti cs\u00f6kken\u00e9s\u00e9vel, ritk\u00e1bban del\u00edrium vagy pszich\u00f3zis. A perif\u00e9ria r\u00e9sz\u00e9r\u0151l k\u00f6zismert a szteroid-myopathia. Az Addison-k\u00f3rra izomgyenges\u00e9g, energiacs\u00f6kken\u00e9s, a ment\u00e1lis funkci\u00f3k \u00e9s az \u00e9letmin\u0151s\u00e9g cs\u00f6kken\u00e9se jellemz\u0151. Az \u00f6sztrog\u00e9n \u00e9s progeszteron saj\u00e1t receptorral rendelkezik, az allopregnanolon a GABA-receptorokon kereszt\u00fcl fejti ki hat\u00e1s\u00e1t. Alapvet\u0151 szerep\u00fck van az agy fejl\u0151d\u00e9s\u00e9nek, az idegk\u00f6r\u00f6k \u00e9s dendritek architekt\u00far\u00e1j\u00e1nak, az axonkapcsolatok s\u0171r\u0171s\u00e9g\u00e9nek \u00e9s a sejtsz\u00e1mnak az alakul\u00e1s\u00e1ban. Befoly\u00e1solj\u00e1k a matur\u00e1ci\u00f3t, neuroprotekci\u00f3t, g\u00f6rcsk\u00e9szs\u00e9get, a kognit\u00edv funkci\u00f3kat, hangulatot, szorong\u00e1st, f\u00e1jdalmat \u00e9s a perif\u00e9ri\u00e1s idegek restit\u00faci\u00f3j\u00e1t. Az androg\u00e9neknek is van kapcsolatuk a kognit\u00edv funkci\u00f3kkal, f\u00e1jdalommal, szorong\u00e1ssal, hangulatzavarokkal, valamint az agresszivit\u00e1ssal is.<\/jats:p>","DOI":"10.1556\/oh.2007.28139","type":"journal-article","created":{"date-parts":[[2007,10,8]],"date-time":"2007-10-08T15:45:46Z","timestamp":1191858346000},"page":"1929-1937","source":"Crossref","is-referenced-by-count":2,"title":["Neurological and psychiatric aspects of some endocrine diseases. The role of neurosteroids and neuroactive steroids"],"prefix":"10.1556","volume":"148","author":[{"given":"Zsuzsa","family":"Aszal\u00f3s","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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