{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T15:52:32Z","timestamp":1718380352036},"reference-count":30,"publisher":"Akademiai Kiado Zrt.","issue":"50","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:p>A carotisstent be\u00fcltet\u00e9se a szignifik\u00e1ns carotis stenosis kezel\u00e9s\u00e9nek egyik lehets\u00e9ges m\u00f3dszere. A beavatkoz\u00e1s sor\u00e1n \u00e9szlelhet\u0151 k\u00f3ros rheologiai viszonyok, fokoz\u00f3d\u00f3 thrombocytaaggreg\u00e1ci\u00f3 \u00e9s szabadgy\u00f6k-k\u00e9pz\u0151d\u00e9s a stenttromb\u00f3zis \u00e9s a korai restenosis rizik\u00f3j\u00e1t n\u00f6velhetik. \n <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n Jelen tanulm\u00e1nyunk c\u00e9lja az volt, hogy megvizsg\u00e1ljuk, hogyan v\u00e1ltoznak a haemorheologiai viszonyok, a thrombocytaaggreg\u00e1ci\u00f3 \u00e9s az oxidat\u00edv stressz carotis stenosis endovascularis kezel\u00e9se sor\u00e1n \u00e9s az azt k\u00f6vet\u0151 napokban. \n <jats:italic>M\u00f3dszer:<\/jats:italic>\n 18 (12 f\u00e9rfi, 6 n\u0151, 66 \u00b1 9 \u00e9v) szignifik\u00e1ns carotis stenosis miatt endovascularis \u00faton kezelt beteg vizsg\u00e1lat\u00e1t v\u00e9gezt\u00fck el. \u00c9rt\u00e9kelt\u00fck a haemorheologiai param\u00e9terek, valamint a thrombocytaaggreg\u00e1ci\u00f3 alakul\u00e1s\u00e1t. Az oxidat\u00edv stressz jellemz\u00e9s\u00e9re a katal\u00e1zaktivit\u00e1st m\u00e9rt\u00fck. A m\u00e9r\u00e9seket k\u00f6zvetlen\u00fcl a beavatkoz\u00e1s el\u0151tt, illetve ut\u00e1n, majd 1, 2, 5 nappal \u00e9s 1 h\u00f3nappal k\u00e9s\u0151bb v\u00e9gezt\u00fck el. A beavatkoz\u00e1s el\u0151tt betegeink tel\u00edt\u0151 d\u00f3zis\u00fa (300 mg) clopidogrelkezel\u00e9sben r\u00e9szes\u00fcltek. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A hematokrit, a plazmafibrinog\u00e9n-koncentr\u00e1ci\u00f3 (Pfc), a teljesv\u00e9r- (Tvv) \u00e9s plazmaviszkozit\u00e1s (Pv) a stentel\u00e9st k\u00f6vet\u0151en azonnal szignifik\u00e1nsan cs\u00f6kkent (\n <jats:italic>p<\/jats:italic>\n &lt; 0,001). A beavatkoz\u00e1s 5. napj\u00e1ra a Tvv, a Pfc, a Pv, a v\u00f6r\u00f6sv\u00e9rtest \u00e9s a thrombocytaaggreg\u00e1ci\u00f3 szignifik\u00e1nsan (\n <jats:italic>p<\/jats:italic>\n &lt; 0,0001) fokoz\u00f3dott a stentel\u00e9s ut\u00e1n m\u00e9rt \u00e9rt\u00e9kekhez k\u00e9pest. Az 1 h\u00f3napos kontrolln\u00e1l ugyanezen param\u00e9terek, kiv\u00e9ve a Tvv, szignifik\u00e1ns cs\u00f6kken\u00e9st mutattak az 5. napi \u00e9rt\u00e9kekhez k\u00e9pest. A katal\u00e1zaktivit\u00e1s beavatkoz\u00e1s ut\u00e1ni napon m\u00e9rt \u00e9rt\u00e9ke az 1 h\u00f3napos kontrollra szignifik\u00e1nsan emelkedett. \n <jats:italic>Konkl\u00fazi\u00f3:<\/jats:italic>\n A haemorheologiai param\u00e9terek \u00e9s a thrombocytaaggreg\u00e1ci\u00f3 a carotisstent-be\u00fcltet\u00e9s kapcs\u00e1n specifikus v\u00e1ltoz\u00e1st mutatnak. A v\u00e9r \u00e1raml\u00e1si viszonyainak k\u00f3ros megv\u00e1ltoz\u00e1sa \u00e9s a thrombocyt\u00e1k fokoz\u00f3d\u00f3 aktiv\u00e1ci\u00f3ja a beavatkoz\u00e1s els\u0151 het\u00e9ben a legkifejezettebbek, a stent thromboticus elz\u00e1r\u00f3d\u00e1s\u00e1t induk\u00e1lhatj\u00e1k. A beavatkoz\u00e1s kapcs\u00e1n induk\u00e1l\u00f3d\u00f3 oxidat\u00edv stressz m\u00e9rt\u00e9ke 1 h\u00f3nap ut\u00e1n cs\u00f6kken szignifik\u00e1nsan.<\/jats:p>","DOI":"10.1556\/oh.2007.28240","type":"journal-article","created":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T19:41:13Z","timestamp":1196797273000},"page":"2365-2370","source":"Crossref","is-referenced-by-count":1,"title":["The effect of carotid stenting on rheological parameters, free radical production and platelet aggregation"],"prefix":"10.1556","volume":"148","author":[{"given":"Gergely","family":"Feh\u00e9r","sequence":"first","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Neurol\u00f3giai Klinika P\u00e9cs R\u00e9t u. 2. 7623"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edit","family":"Bagoly","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Neurol\u00f3giai Klinika P\u00e9cs R\u00e9t u. 2. 7623"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"K\u00f6v\u00e9r","sequence":"additional","affiliation":[{"name":"2 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Idegseb\u00e9szeti Klinika P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Koltai","sequence":"additional","affiliation":[{"name":"3 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Belgy\u00f3gy\u00e1szati Klinika P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Hant\u00f3","sequence":"additional","affiliation":[{"name":"3 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Belgy\u00f3gy\u00e1szati Klinika P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Pozsgai","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Neurol\u00f3giai Klinika P\u00e9cs R\u00e9t u. 2. 7623"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1muel","family":"Komoly","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Neurol\u00f3giai Klinika P\u00e9cs R\u00e9t u. 2. 7623"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"D\u00f3czi","sequence":"additional","affiliation":[{"name":"2 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Idegseb\u00e9szeti Klinika P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1lm\u00e1n","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"3 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Belgy\u00f3gy\u00e1szati Klinika P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Szap\u00e1ry","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Neurol\u00f3giai Klinika P\u00e9cs R\u00e9t u. 2. 7623"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"e85","volume":"14","year":"2006","journal-title":"Circulation"},{"key":"atypb2","first-page":"901","volume":"141","year":"2000","journal-title":"Orv. Hetil."},{"key":"atypb3","first-page":"2","volume":"9","year":"2003","journal-title":"Agy\u00e9rbetegs\u00e9gek"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/01.STR.19.5.634","volume":"19","year":"1988","journal-title":"Stroke"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/01.STR.22.2.162","volume":"22","year":"1991","journal-title":"Stroke"},{"key":"atypb7","first-page":"33","volume":"24","year":"2001","journal-title":"Clin. Hemorheol. and Microcirc."},{"key":"atypb8","first-page":"159","volume":"32","year":"2005","journal-title":"Clin. Hemorheol. and Microcirc."},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0735-1097(97)00070-3","volume":"29","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0891-5849(96)00279-1","volume":"22","year":"1997","journal-title":"Free. Radic. Biol. Med."},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1161\/01.CIR.0000069943.41206.BD","volume":"107","year":"2003","journal-title":"Circulation"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1161\/01.ATV.0000145574.90840.7d","volume":"24","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/01.HYP.0000100443.09293.4F","volume":"42","year":"2003","journal-title":"Hypertension"},{"key":"atypb14","first-page":"2975","volume":"105","year":"2002","journal-title":"Circulation"},{"key":"atypb16","first-page":"8412","volume":"86","year":"1989","journal-title":"Cell. Biology"},{"key":"atypb17","first-page":"1417","volume":"136","year":"1990","journal-title":"Am. J. Pathol."},{"key":"atypb18","first-page":"285","volume":"2","year":"2000","journal-title":"Curr. Intervent. Cardiol. Reports"},{"key":"atypb19","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1148\/radiol.2272020183","volume":"227","year":"2003","journal-title":"Radiology"},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0735-1097(98)81613-6","volume":"31","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3171\/jns.1999.90.4.0688","volume":"90","year":"1999","journal-title":"J. Neurosurg."},{"key":"atypb22","first-page":"E10","volume":"146","year":"2003","journal-title":"Am. Heart. J."},{"key":"atypb23","first-page":"E7","volume":"18","year":"2005","journal-title":"Neurosurg. Focus"},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000205234","volume":"17","year":"1957","journal-title":"Acta Haematol."},{"key":"atypb25","first-page":"329","volume":"14","year":"1994","journal-title":"Clin. Hemorheol."},{"key":"atypb26","first-page":"75","volume":"24","year":"2001","journal-title":"Clin. Hemorheol."},{"key":"atypb27","first-page":"301","volume":"37","year":"2000","journal-title":"Biorheology"},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1078-5884(97)80290-0","volume":"14","year":"1997","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"atypb29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/01.STR.0000152333.75932.fe","volume":"36","year":"2005","journal-title":"Stroke"},{"key":"atypb30","first-page":"31","volume":"92","year":"1995","journal-title":"Circulation"},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/204748739900600413","volume":"6","year":"1999","journal-title":"J. Cardiovasc. Risk"},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1177\/107602960100700207","volume":"7","year":"2001","journal-title":"Clin. Appl. Thromb. Hemost."}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/148\/50\/article-p2365.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/148\/50\/article-p2365.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T10:13:01Z","timestamp":1590574381000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/148\/50\/article-p2365.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,1]]},"references-count":30,"journal-issue":{"issue":"50"},"URL":"https:\/\/doi.org\/10.1556\/oh.2007.28240","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,1]]}}}