{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T05:08:53Z","timestamp":1737781733847,"version":"3.33.0"},"reference-count":57,"publisher":"Akademiai Kiado Zrt.","issue":"52","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:p>A parenchim\u00e1s szervek \u2013 mint p\u00e9ld\u00e1ul a m\u00e1j \u2013 abnorm\u00e1lis zs\u00edrfelhalmoz\u00f3d\u00e1s\u00e1t zs\u00edros \u00e1talakul\u00e1snak nevezz\u00fck. A m\u00e1j elzs\u00edrosod\u00e1s\u00e1nak h\u00e1tter\u00e9ben a m\u00e1jsejtek zs\u00edrfelvev\u0151 \u00e9s zs\u00edrlead\u00f3 folyamatainak egyens\u00falyzavara \u00e1ll, mi\u00e1ltal a felesleges triglicerid felhalmoz\u00f3dik a hepatocyt\u00e1kban. Norm\u00e1l esetben a sejtek kb. 5%-a tartalmaz trigliceridet, zs\u00edrm\u00e1j eset\u00e9n ez az \u00e9rt\u00e9k 50% f\u00f6l\u00e9 is emelkedhet. 50% alatt m\u00e1jelzs\u00edrosod\u00e1sr\u00f3l, 50% felett zs\u00edrm\u00e1jr\u00f3l besz\u00e9l\u00fcnk. Enyh\u00e9bb esetben nem felt\u00e9tlen\u00fcl okoz sejtm\u0171k\u00f6d\u00e9si zavart, s\u00falyosabb form\u00e1n\u00e1l azonban igen, sokszor a sejthal\u00e1l el\u0151fut\u00e1ra. A zs\u00edrm\u00e1j olyan k\u00f3r\u00e1llapotnak tekinthet\u0151, mely \u00e9rz\u00e9kenny\u00e9 teszi a m\u00e1jat egy\u00e9b toxikus hat\u00e1sokkal szemben. Nem \u00f6n\u00e1ll\u00f3 betegs\u00e9g, legt\u00f6bbsz\u00f6r valamilyen \u00e1rtalom, egy\u00e9b k\u00f3rfolyamat k\u00eds\u00e9r\u0151 jelens\u00e9ge. \u00d6nmag\u00e1ban \u2013 bizonyos s\u00falyoss\u00e1gi fokig (a fibrosis megjelen\u00e9s\u00e9ig) \u2013 reverz\u00edbilis k\u00e1rosod\u00e1st jelent, a kiv\u00e1lt\u00f3 ok megsz\u0171n\u00e9sekor a m\u00e1j a felesleges triglicerid-tartalm\u00e1t leadja. Kezelni az alapfolyamatot kell; m\u00e9g nem ismert olyan specifikus gy\u00f3gyszer, amely a hepatocyt\u00e1kban lerak\u00f3dott zs\u00edrt cs\u00f6kkenti.<\/jats:p>","DOI":"10.1556\/oh.2007.28270","type":"journal-article","created":{"date-parts":[[2007,12,19]],"date-time":"2007-12-19T20:11:01Z","timestamp":1198095061000},"page":"2461-2468","source":"Crossref","is-referenced-by-count":2,"title":["Fatty liver in childhood"],"prefix":"10.1556","volume":"148","author":[{"given":"\u00c1d\u00e1m","family":"Eiszrich","sequence":"first","affiliation":[{"name":"1 F\u0151v\u00e1rosi \u00d6nkorm\u00e1nyzat Heim P\u00e1l Gyermekk\u00f3rh\u00e1z Madar\u00e1sz utcai K\u00f3rh\u00e1za Budapest Madar\u00e1sz V. u. 22\u201324. 1131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Feh\u00e9r","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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