{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T02:56:10Z","timestamp":1648522570829},"reference-count":16,"publisher":"Akademiai Kiado Zrt.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:p>S\u00falyos perif\u00e9ri\u00e1s art\u00e9ri\u00e1s \u00e9rbetegs\u00e9gekben a gy\u00f3gyszeres \u00e9s\/vagy \u00e9rseb\u00e9szeti beavatkoz\u00e1sok kimer\u00fcl\u00e9s\u00e9t k\u00f6vet\u0151en a t\u0171rhetetlen f\u00e1jdalom, kiterjedt v\u00e9gtagi fek\u00e9lyek, gangraen\u00e1k megsz\u00fcntet\u00e9s\u00e9nek egyetlen m\u00f3dja a v\u00e9gtag amput\u00e1ci\u00f3ja. \n <jats:italic>Betegek \u00e9s m\u00f3dszerek:<\/jats:italic>\n A szerz\u0151k \u2013 haz\u00e1nkban els\u0151k\u00e9nt \u2013 5 el\u0151rehaladott perif\u00e9ri\u00e1s art\u00e9ri\u00e1s \u00e9rbetegben (1 arteriosclerosis obliterans \u00e9s 4 thromboangiitis obliterans) autol\u00f3g csontvel\u0151i eredet\u0171 \u0151ssejtter\u00e1pi\u00e1t v\u00e9geztek. A csontvel\u0151i \u0151ssejteket (CD34+ sejtek) crista biopsia v\u00e9gz\u00e9s\u00e9vel nyert\u00e9k. M\u00e1gneses sejtszepar\u00e1l\u00e1ssal CD34+ sejtszuszpenzi\u00f3t \u00e1ll\u00edtottak el\u0151. Meghat\u00e1rozt\u00e1k a CD34+, CD133+ \u00e9s CD45\u00b1 sejtek sz\u00e1m\u00e1t \u00e9s ar\u00e1ny\u00e1t. Az \u0151ssejtszuszpenzi\u00f3t intramuscularis injekci\u00f3 form\u00e1j\u00e1ban a beteg v\u00e9gtagba juttatt\u00e1k vissza. Betegenk\u00e9nt 0,37\u20131,14 \u00d7 10\n <jats:sup>5<\/jats:sup>\n \/kg \u0151ssejt visszaad\u00e1s\u00e1ra ker\u00fclt sor. Betegeiket 12 h\u00f3napig k\u00f6vett\u00e9k. Vizsg\u00e1latok t\u00f6rt\u00e9ntek a beavatkoz\u00e1s el\u0151tt \u00e9s ut\u00e1n (1, 3, 6, 9 \u00e9s 12 h\u00f3nappal). Klinikai vizsg\u00e1latok: nyugalmi f\u00e1jdalom, dysbasi\u00e1s t\u00e1vols\u00e1g, ischaemi\u00e1s fek\u00e9lyek gy\u00f3gyhajlama, boka-kar index. Laborat\u00f3riumi vizsg\u00e1latok: angiogr\u00e1fia (az \u0151ssejtter\u00e1pia el\u0151tt \u00e9s ut\u00e1n 1 \u00e9s 6 h\u00f3nappal), duplex ultrahang- \u00e9s l\u00e9zer-Doppler-scan, transcutan oxig\u00e9ntenzi\u00f3 m\u00e9r\u00e9se, az endothelfunkci\u00f3k vizsg\u00e1lata. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A nyugalmi f\u00e1jdalom mind az \u00f6t beteg\u00fck eset\u00e9ben megsz\u0171nt. A dysbasi\u00e1s t\u00e1vols\u00e1g szignifik\u00e1nsan n\u0151tt (36\/440 m). H\u00e1rom beteg v\u00e9gtagi ischaemi\u00e1s fek\u00e9lye begy\u00f3gyult, egy beteg nagym\u00e9ret\u0171 fek\u00e9lye l\u00e9nyegesen kisebb\u00e9 \u00e9s fel\u00fcletesebb\u00e9 v\u00e1lt, egy betegben a v\u00e9gtagi fek\u00e9ly nem v\u00e1ltozott. A kezelt oldalon a boka-kar index szignifik\u00e1nsan n\u0151tt (0,41\/0,83) tizenk\u00e9t h\u00f3nappal az \u0151ssejtter\u00e1pi\u00e1t k\u00f6vet\u0151en, s nem v\u00e1ltozott az ellenoldalon. H\u00e1rom betegben tapasztaltak sz\u00e1mottev\u0151 v\u00e1ltoz\u00e1st angiogr\u00e1fi\u00e1val az \u0151ssejtter\u00e1pia ut\u00e1n hat h\u00f3nappal. Csak szer\u00e9ny javul\u00e1st \u00e9szleltek color-Doppler- \u00e9s l\u00e9zer-Doppler-vizsg\u00e1latokkal. Az \u0151ssejtter\u00e1pia el\u0151tt \u00e9s ut\u00e1n 1, 6 \u00e9s 12 h\u00f3nappal a transcutan oxig\u00e9ntenzi\u00f3-\u00e9rt\u00e9kek a l\u00e1bh\u00e1ton 18,10\/16,78\/23,83\/37,50 Hgmm-re, m\u00edg a l\u00e1bsz\u00e1ron 36,66\/31,25\/45,00\/37,30 Hgmm-re v\u00e1ltoztak. A makro- \u00e9s mikrocirkul\u00e1ci\u00f3s param\u00e9terek nem mutattak javul\u00e1st az \u0151ssejtter\u00e1pi\u00e1t k\u00f6vet\u0151en 1 h\u00f3nappal, azonban az \u0151ssejtter\u00e1pia ut\u00e1n 3, 6, 9 \u00e9s 12 h\u00f3nappal m\u00e1r m\u00e9rhet\u0151 javul\u00e1st tapasztaltak. Sz\u00f6v\u0151dm\u00e9nyt, mell\u00e9khat\u00e1st nem \u00e9szleltek. \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n Klinikai eredm\u00e9nyeik alapj\u00e1n az autol\u00f3g csontvel\u0151i eredet\u0171 \u0151ssejtter\u00e1pi\u00e1t hat\u00e1sosnak, tart\u00f3snak \u00e9s biztons\u00e1gosnak tartj\u00e1k el\u0151rehaladott perif\u00e9ri\u00e1s art\u00e9ri\u00e1s \u00e9rbetegs\u00e9gben. Sz\u00fcks\u00e9g van tov\u00e1bbi klinikai tapasztalatgy\u0171jt\u00e9sre.<\/jats:p>","DOI":"10.1556\/oh.2008.28125","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T00:07:17Z","timestamp":1205539637000},"page":"531-540","source":"Crossref","is-referenced-by-count":3,"title":["A pilot study with autologous bone marrow-derived stem cell therapy in patients with severe peripheral arterial disorder"],"prefix":"10.1556","volume":"149","author":[{"given":"Zolt\u00e1n","family":"Boda","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika, Haemostasis Tansz\u00e9k Debrecen Nagyerdei krt. 98. 4012"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Udvardy","sequence":"additional","affiliation":[{"name":"2 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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Seb\u00e9szeti Klinika Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Hunyadi","sequence":"additional","affiliation":[{"name":"7 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Sejtter\u00e1pia Klinikai K\u00f6zpont Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Sipos","sequence":"additional","affiliation":[{"name":"7 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Sejtter\u00e1pia Klinikai K\u00f6zpont Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Kappelmayer","sequence":"additional","affiliation":[{"name":"8 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Klinikai Biok\u00e9miai \u00e9s Molekul\u00e1ris Patol\u00f3giai Int\u00e9zet Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Ver\u00e9b","sequence":"additional","affiliation":[{"name":"9 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Immunol\u00f3giai Int\u00e9zet Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Rajnav\u00f6lgyi","sequence":"additional","affiliation":[{"name":"9 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Immunol\u00f3giai Int\u00e9zet Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"39","volume":"13","year":"2006","journal-title":"\u00c9rbetegs\u00e9gek"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(02)09670-8","volume":"360","year":"2002","journal-title":"Lancet"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s10047-006-0351-2","volume":"9","year":"2006","journal-title":"J. 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Wochenschr."}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/149\/12\/article-p531.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/149\/12\/article-p531.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T10:14:20Z","timestamp":1590574460000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/149\/12\/article-p531.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,1]]},"references-count":16,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.1556\/oh.2008.28125","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,1]]}}}