{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T06:39:36Z","timestamp":1648622376559},"reference-count":15,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:p>Az ut\u00f3bbi \u00e9vekben kr\u00f3nikus lymphoid leukaemi\u00e1ban \u00faj prognosztikai faktorok vizsg\u00e1lata ker\u00fclt a figyelem k\u00f6z\u00e9ppontj\u00e1ba. A citogenetikai elt\u00e9r\u00e9sek, az immunglobulin-neh\u00e9zl\u00e1nc g\u00e9nmut\u00e1ci\u00f3s st\u00e1tusza, a CD38- \u00e9s ZAP70-expresszi\u00f3 mind a k\u00f6zelm\u00faltban megismert prognosztikus faktorok, de kev\u00e9s az adat a multidrog-rezisztencia jelent\u0151s\u00e9g\u00e9r\u0151l. \n <jats:italic>C\u00e9lok:<\/jats:italic>\n A tanulm\u00e1ny c\u00e9lja genetikai, expresszi\u00f3s \u00e9s funkcion\u00e1lis szinten jellemezni 82 kr\u00f3nikus lymphoid leukaemi\u00e1ban szenved\u0151 beteg multidrog-rezisztenci\u00e1j\u00e1nak saj\u00e1toss\u00e1gait, \u00e9s vizsg\u00e1lni azok \u00f6sszef\u00fcgg\u00e9s\u00e9t a betegek t\u00fal\u00e9l\u00e9s\u00e9vel \u00e9s a kezel\u00e9sre adott v\u00e1lasszal. \n <jats:italic>M\u00f3dszerek:<\/jats:italic>\n a szerz\u0151k 66 betegn\u00e9l vizsg\u00e1lt\u00e1k az MDR-1 \n <jats:italic>g\u00e9n<\/jats:italic>\n ben \u2013 Light Cycler Real Time PCR seg\u00edts\u00e9g\u00e9vel meghat\u00e1rozott \u2013 \u201eSingle Nucleotid Polymorphism\u201d saj\u00e1toss\u00e1got, amely irodalmi adatok szerint a P-glikoprotein expresszi\u00f3j\u00e1t befoly\u00e1solja. \u00d6sszesen 82 betegn\u00e9l \u00e1raml\u00e1si citometria sor\u00e1n anti-P-glikoprotein monoklon\u00e1lis antitest seg\u00edts\u00e9g\u00e9vel a P-glikoprotein-\n <jats:italic>expresszi\u00f3<\/jats:italic>\n t, az \u00fan. calcein-verapamil teszttel pedig a multidrog-rezisztencia \n <jats:italic>funkci\u00f3j\u00e1t<\/jats:italic>\n vizsg\u00e1lt\u00e1k. A kezel\u00e9sre adott v\u00e1laszt 35 betegn\u00e9l vizsg\u00e1lt\u00e1k, a statisztikai elemz\u00e9sn\u00e9l Fischer-tesztet alkalmazva. A t\u00fal\u00e9l\u00e9si anal\u00edzist a teljes beteganyagon elv\u00e9gezt\u00e9k (\n <jats:italic>n<\/jats:italic>\n = 82, Log-rank-teszt). \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n Az irodalmi adatokkal ellent\u00e9tben a szerz\u0151k nem tal\u00e1ltak korrel\u00e1ci\u00f3t a vizsg\u00e1lt h\u00e1rom multidrogrezisztencia-teszt k\u00f6z\u00f6tt. A kezel\u00e9sre adott v\u00e1laszt vizsg\u00e1lva 35 kezelt betegb\u0151l 13 nonrespondernek, 22 pedig respondernek bizonyult. A P-glikoprotein-pozit\u00edv fenot\u00edpus\u00fa esetek (\n <jats:italic>n<\/jats:italic>\n = 9) 89%-ban klinikailag nonrespondernek bizonyultak (9 P-glikoprotein-pozit\u00edv kr\u00f3nikus lymphoid leukaemi\u00e1s beteg k\u00f6z\u00fcl 8 nonresponder volt), a P-glikoprotein-negat\u00edv esetek (\n <jats:italic>n<\/jats:italic>\n = 26) pedig 80%-ban j\u00f3 ter\u00e1pi\u00e1s v\u00e1laszt mutattak (26 P-glikoprotein-negat\u00edv beteg k\u00f6z\u00fcl 21 responder) (\n <jats:italic>p<\/jats:italic>\n &lt; 0,001). Az \u00e1tlagos v\u00e1rhat\u00f3 t\u00fal\u00e9l\u00e9sben is jelent\u0151s, b\u00e1r nem szignifik\u00e1ns (\n <jats:italic>p<\/jats:italic>\n = 0,106) k\u00fcl\u00f6nbs\u00e9get \u00e9szleltek (84 vs 203 h\u00f3nap). \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n A vizsg\u00e1lt h\u00e1rom laborat\u00f3riumi param\u00e9ter k\u00f6z\u00fcl a P-glikoprotein sejtfelsz\u00edni jelenl\u00e9te a legink\u00e1bb relev\u00e1ns adat kr\u00f3nikus lymphoid leukaemi\u00e1ban a kemorezisztencia el\u0151jelz\u00e9s\u00e9re \u00e9s a t\u00fal\u00e9l\u00e9ssel kapcsolatban is prognosztikai faktork\u00e9nt \u00e9rt\u00e9kelhet\u0151.<\/jats:p>","DOI":"10.1556\/oh.2008.28203","type":"journal-article","created":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T21:50:23Z","timestamp":1201038623000},"page":"161-167","source":"Crossref","is-referenced-by-count":1,"title":["Multidrug resistance in chronic lymphocytic leukemia"],"prefix":"10.1556","volume":"149","author":[{"given":"Tam\u00e1s","family":"Szendrei","sequence":"first","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, Orvostudom\u00e1nyi \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum I. 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