{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T16:46:59Z","timestamp":1648831619415},"reference-count":40,"publisher":"Akademiai Kiado Zrt.","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:p>A gy\u00f3gyszermell\u00e9khat\u00e1sok felismer\u00e9se \u00e9s a t\u00fcneteket kiv\u00e1lt\u00f3 gy\u00f3gyszer oki szerep\u00e9nek bizony\u00edt\u00e1sa komoly felk\u00e9sz\u00fclts\u00e9get ig\u00e9nyel. E k\u00f6zlem\u00e9ny c\u00e9lja a gy\u00f3gyszerallergi\u00e1s reakci\u00f3k diagnosztikai lehet\u0151s\u00e9geinek r\u00f6vid \u00e1ttekint\u00e9se \u00e9s a lymphocytatranszform\u00e1ci\u00f3s teszt gy\u00f3gyszer-hiperszenzitivit\u00e1si reakci\u00f3kban val\u00f3 bizony\u00edt\u00f3 szerep\u00e9nek b\u0151rgy\u00f3gy\u00e1szati szempontok szerinti \u00e9rt\u00e9kel\u00e9se. A lymphocytatranszform\u00e1ci\u00f3s teszt azon a megfigyel\u00e9sen alapul, hogy a gy\u00f3gyszerrel val\u00f3 els\u0151 tal\u00e1lkoz\u00e1skor kialakult antig\u00e9nspecifikus T-sejtek oszt\u00f3dni kezdenek az antig\u00e9nnel val\u00f3 in vitro megism\u00e9telt tal\u00e1lkoz\u00e1s ut\u00e1n. A szenzibiliz\u00e1ci\u00f3t az oszt\u00f3d\u00f3 T-sejtekbe t\u00f6rt\u00e9n\u0151 \n <jats:sup>3<\/jats:sup>\n H-timidin-be\u00e9p\u00fcl\u00e9s m\u00e9rt\u00e9ke jelzi. A hat\u00f3anyag-specifikus T-sejtek szinte mindig r\u00e9szt vesznek a gy\u00f3gyszerallergi\u00e1s reakci\u00f3kban, ez\u00e9rt a vizsg\u00e1lat el\u0151nye, hogy sok gy\u00f3gyszern\u00e9l \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 immunreakci\u00f3k eseteiben egyar\u00e1nt j\u00f3l alkalmazhat\u00f3. H\u00e1tr\u00e1nya a munkaig\u00e9nyess\u00e9g, valamint az, hogy specificit\u00e1s\u00e1nak \u00e9s szenzitivit\u00e1s\u00e1nak bizony\u00edt\u00e1s\u00e1hoz hi\u00e1nyoznak a sz\u00e9les k\u00f6r\u0171, nagy beteganyagon elv\u00e9gzett tanulm\u00e1nyok. Emiatt a teszt nem egy\u00e9rtelm\u0171en elfogadott a gy\u00f3gyszerallergia igazol\u00e1s\u00e1ra. Hi\u00e1nyoss\u00e1gai ellen\u00e9re azonban, jobb predikt\u00edv \u00e9rt\u00e9k\u0171 egy\u00e9b vizsg\u00e1latok hi\u00e1ny\u00e1ban, a lymphocytatranszform\u00e1ci\u00f3s tesztnek fontos szerepe van a gy\u00f3gyszerallergi\u00e1k diagnosztiz\u00e1l\u00e1sa ter\u00e9n.<\/jats:p>","DOI":"10.1556\/oh.2008.28215","type":"journal-article","created":{"date-parts":[[2008,6,7]],"date-time":"2008-06-07T01:03:05Z","timestamp":1212800585000},"page":"1107-1114","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic methods for confirming drug-allergy \u2013 the lymphocyte transformation test in dermatology"],"prefix":"10.1556","volume":"149","author":[{"given":"Sarolta","family":"Mak\u00f3","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest M\u00e1ria u. 41. 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9ka","family":"Lepesi-Benk\u0151","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest M\u00e1ria u. 41. 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Marschalk\u00f3","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest M\u00e1ria u. 41. 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6ngyv\u00e9r","family":"So\u00f3s","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest M\u00e1ria u. 41. 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarolta","family":"K\u00e1rp\u00e1ti","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika Budapest M\u00e1ria u. 41. 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"Drug hypersensitivity","year":"2007"},{"key":"atypb2","volume-title":"Klinikai Immunol\u00f3gia","year":"2006"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1034\/j.1600-0536.2001.450601.x","volume":"45","year":"2001","journal-title":"Contact Dermat."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(00)00396-6","volume":"158","year":"2001","journal-title":"Toxicology"},{"key":"atypb5","first-page":"230","volume":"37","year":"2005","journal-title":"Allerg. 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Ges."},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s00105-006-1167-y","volume":"57","year":"2006","journal-title":"Hautarzt"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1398-9995.2004.00547.x","volume":"59","year":"2004","journal-title":"Allergy"},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.taap.2003.09.023","volume":"195","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0009-2797(98)00021-0","volume":"113","year":"1998","journal-title":"Chem. Biol. Interact."},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jaci.2006.03.005","volume":"118","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/sj.bjp.0704074","volume":"133","year":"2001","journal-title":"Br. J. 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Pathol."},{"key":"atypb22","first-page":"77","volume":"6","year":"1983","journal-title":"Allergologie"},{"key":"atypb23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2222.1997.tb00690.x","volume":"27","year":"1997","journal-title":"Clin. Exp. Allergy"},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1046\/j.1365-2222.2001.01164.x","volume":"31","year":"2001","journal-title":"Clin. Exp. Allergy"},{"key":"atypb25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1046\/j.1365-2222.2000.00787.x","volume":"30","year":"2000","journal-title":"Clin. Exp. Allergy"},{"key":"atypb26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1034\/j.1398-9995.2001.000115.x","volume":"56","year":"2001","journal-title":"Allergy"},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1124\/mol.63.3.732","volume":"63","year":"2003","journal-title":"Mol. 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