{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T22:37:47Z","timestamp":1649025467072},"reference-count":33,"publisher":"Akademiai Kiado Zrt.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:p>A 2006. \u00e9vi aj\u00e1nl\u00e1sok szerint az alapell\u00e1t\u00e1sban is alkalmazni kell a sz\u00e9rumkreatininb\u0151l k\u00e9plettel sz\u00e1m\u00edtott glomerulus filtr\u00e1ci\u00f3s r\u00e1t\u00e1t, amely seg\u00edt a kr\u00f3nikus vesebetegs\u00e9g korai felismer\u00e9s\u00e9ben. Emiatt el\u0151t\u00e9rbe ker\u00fcltek a Jaffe-f\u00e9le kreatininmeghat\u00e1roz\u00e1s korl\u00e1tai, \u00e9s az eredm\u00e9nyek \u00f6sszevethet\u0151s\u00e9ge \u00e9rdek\u00e9ben felmer\u00fclt az ig\u00e9ny a leggyakrabban haszn\u00e1lt Jaffe- \u00e9s az \u00fajabb kreatininmeghat\u00e1roz\u00e1sok harmoniz\u00e1ci\u00f3j\u00e1ra. A kinetikus Jaffe-f\u00e9le kreatininmeghat\u00e1roz\u00e1s h\u00e1tr\u00e1nya, hogy nem el\u00e9g specifikus. Ezen jav\u00edtottak az elm\u00falt \u00e9vtizedben bevezetett enzimatikus, kompenz\u00e1lt Jaffe \u00e9s nagyfelbont\u00e1s\u00fa folyad\u00e9kkromatogr\u00e1fi\u00e1s m\u00f3dszerek. Az \u00fajabb m\u00f3dszerekkel kapott kreatinin\u00e9rt\u00e9kek m\u00e1r pontosabbak, de alacsonyabb \u00e9rt\u00e9k\u00fck miatt a kor\u00e1bbi formul\u00e1kkal (4 v\u00e1ltoz\u00f3s Modification of Diet in Renal Disease-186, Cockcroft\u2013Gault, kvadratikus) nem lehet bel\u0151l\u00fck glomerulus filtr\u00e1ci\u00f3s r\u00e1t\u00e1t sz\u00e1m\u00edtani, mert durv\u00e1n torz\u00edtan\u00e1k azt. Az \u00faj kreatininm\u00f3dszerek miatt a kor\u00e1bbi sz\u00e1m\u00edt\u00e1si m\u00f3d, s \u00edgy a kr\u00f3nikus vesebetegs\u00e9g st\u00e1dium\u00e1nak meghat\u00e1roz\u00e1sa is bizonytalann\u00e1 v\u00e1lt. Emiatt 2006-ban m\u00f3dos\u00edtott\u00e1k a 4-v\u00e1ltoz\u00f3s Modification of Diet in Renal Disease-186 formul\u00e1t, \u00e9s az \u00faj (izot\u00f3pdiluti\u00f3s t\u00f6megspektrometri\u00e1s referenciam\u00f3dszerre visszavezethet\u0151) kreatininhez csak az \u00faj 4 v\u00e1ltoz\u00f3s Modification of Diet in Renal Disease-175 k\u00e9plet aj\u00e1nlott. A szerz\u0151k \u00f6sszevetik a kreatininm\u00f3dszerek diagnosztikai \u00e9rt\u00e9k\u00e9t \u00e9s korl\u00e1tait.<\/jats:p>","DOI":"10.1556\/oh.2008.28262","type":"journal-article","created":{"date-parts":[[2008,4,12]],"date-time":"2008-04-12T00:18:03Z","timestamp":1207959483000},"page":"317-323","source":"Crossref","is-referenced-by-count":1,"title":["Challenge and limitations in determination of serum creatinine"],"prefix":"10.1556","volume":"149","author":[{"given":"Anna","family":"V. Ol\u00e1h","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum Klinikai Biok\u00e9miai \u00e9s Molekul\u00e1ris Patol\u00f3giai Int\u00e9zet Debrecen Nagyerdei krt. 98. Pf. 70. 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertalan","family":"Fodor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"4 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Klinikai K\u00e9miai Int\u00e9zet Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1309\/XQNL7L157DKQGMKA","volume":"37","year":"2006","journal-title":"Lab. Med."},{"key":"atypb3","first-page":"391","volume":"10","year":"1886","journal-title":"Zeit. Physiol. Chem."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/000456328602300101","volume":"23","year":"1986","journal-title":"Ann. Clin. Biochem."},{"key":"atypb5","first-page":"1422","volume":"21","year":"1975","journal-title":"Ann. 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