{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T22:40:01Z","timestamp":1708814401570},"reference-count":40,"publisher":"Akademiai Kiado Zrt.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:p>A gastroparesis a gyomor \u00fcr\u00fcl\u00e9s\u00e9nek olyan zavara, amely mechanikus elz\u00e1r\u00f3d\u00e1s n\u00e9lk\u00fcl jelentkezik. T\u00fcnetei k\u00f6z\u00f6tt a h\u00e1nyinger, a h\u00e1ny\u00e1s, a puffad\u00e1s, a korai telts\u00e9g\u00e9rzet \u00e9s a diszkomfort\u00e9rz\u00e9s az els\u0151dlegesek. S\u00falyos esetekben s\u00falyveszt\u00e9s, kisz\u00e1rad\u00e1s, elektrolitzavarok, alult\u00e1pl\u00e1lts\u00e1g is k\u00f6vetkezm\u00e9nye lehet. A gastroparesis eseteinek t\u00f6bbs\u00e9ge idiopathi\u00e1s, emellett az esetek kb. 25\u201330%-\u00e1nak h\u00e1tter\u00e9ben hossz\u00fa ideje fenn\u00e1ll\u00f3 diabetes mellitus \u00e1ll. A diab\u00e9teszes gastroparesis a v\u00e9rcukor-be\u00e1ll\u00edt\u00e1st jelent\u0151sen megnehez\u00edtheti, kezel\u00e9se jelent\u0151s kih\u00edv\u00e1st jelent. A gyakori, kis mennyis\u00e9g\u0171 \u00e9tkez\u00e9sek \u00e9s pszichol\u00f3giai t\u00e1mogat\u00e1s mellett t\u00f6bb gy\u00f3gyszeres lehet\u0151s\u00e9g is rendelkez\u00e9sre \u00e1ll, azonban ezek hat\u00e9konys\u00e1ga korl\u00e1tozott, \u00e9s meggy\u0151z\u0151, randomiz\u00e1lt tanulm\u00e1nyok csak kev\u00e9s esetben \u00e1llnak rendelkez\u00e9sre. A sz\u00f3ba j\u00f6v\u0151 szerek k\u00f6z\u00f6tt a prokinetikumok (erythromycin, domperidon, metoclopramid) \u00e9s antiemetikumok (fenotiazinok, szerotonin-antagonist\u00e1k, butirofenonok) a legink\u00e1bb elterjedtek. Az \u00fajabb, hat\u00e9konynak t\u0171n\u0151 szerek k\u00f6z\u00fcl a szerotonin 5-HT4-receptor-agonist\u00e1k \u00e9s dopamin D2-receptor-antagonist\u00e1k alkalmaz\u00e1sa j\u00f6het sz\u00f3ba. Botulinum toxin pylorus sphincterbe injekt\u00e1l\u00e1s\u00e1val n\u00e9h\u00e1ny tanulm\u00e1nyban javul\u00f3 gyomor\u00fcr\u00fcl\u00e9st \u00e9s a t\u00fcnetek enyh\u00fcl\u00e9s\u00e9t \u00e9szlelt\u00e9k. Az egyik leghat\u00e9konyabb megold\u00e1snak a gyomor elektromos serkent\u00e9se t\u0171nik, amelynek mind alacsony, mind magas frekvenci\u00e1j\u00fa form\u00e1ja a t\u00fcneteket enyh\u00edtheti. A gastrostomia\/jejunostomia, illet\u0151leg egy\u00e9b seb\u00e9szeti megold\u00e1sok csak v\u00e9gs\u0151 esetben mer\u00fclnek fel.<\/jats:p>","DOI":"10.1556\/oh.2008.28293","type":"journal-article","created":{"date-parts":[[2008,4,12]],"date-time":"2008-04-12T00:18:57Z","timestamp":1207959537000},"page":"393-398","source":"Crossref","is-referenced-by-count":2,"title":["Gastroparesis and its treatment options"],"prefix":"10.1556","volume":"149","author":[{"given":"P\u00e9ter","family":"Igaz","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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