{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T06:16:32Z","timestamp":1738217792131,"version":"3.34.0"},"reference-count":46,"publisher":"Akademiai Kiado Zrt.","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:p>A sziszt\u00e9m\u00e1s lupus erythematosus (SLE) f\u0151leg a fogamz\u00f3k\u00e9pes n\u0151ket \u00e9rint\u0151 betegs\u00e9g. Az SLE-s terhesekn\u00e9l a spont\u00e1n abortusz, a praeeclampsia, az intrauterin retard\u00e1ci\u00f3, valamint a magzati hal\u00e1l \u00e9s a korasz\u00fcl\u00e9s kock\u00e1zata magasabb. A spont\u00e1n abortuszok el\u0151fordul\u00e1sa szorosan kapcsol\u00f3dik az antifoszfolipid-antitestek jelenl\u00e9t\u00e9hez. A betegs\u00e9g \u00f6nmag\u00e1ban nem kontraindik\u00e1ci\u00f3ja a terhess\u00e9gnek, legal\u00e1bb f\u00e9l\u00e9ves remisszi\u00f3 ut\u00e1n c\u00e9lszer\u0171 azonban terhess\u00e9get v\u00e1llalni. A terhess\u00e9g alatt v\u00e9gbemen\u0151 \u00e9lettani v\u00e1ltoz\u00e1sok hasonl\u00f3ak lehetnek a lupus t\u00fcneteihez, \u00edgy ezeket a v\u00e1ltoz\u00e1sokat el kell k\u00fcl\u00f6n\u00edteni a lupus okozta t\u00fcnetekt\u0151l. Az SLE-ben szenved\u0151 v\u00e1rand\u00f3s any\u00e1knak javasolt a rendszeres tal\u00e1lkoz\u00e1s nemcsak n\u0151gy\u00f3gy\u00e1szukkal, hanem reumatol\u00f3gussal is annak \u00e9rdek\u00e9ben, hogy id\u0151ben megt\u00f6rt\u00e9njen az esetleges sz\u00f6v\u0151dm\u00e9nyek felismer\u00e9se \u00e9s azok kezel\u00e9se. Fontos tov\u00e1bb\u00e1 az anyai betegs\u00e9g alapos ellen\u0151rz\u00e9se nemcsak a terhess\u00e9g alatt, hanem az azt megel\u0151z\u0151, valamint az azt k\u00f6vet\u0151 id\u0151szakokban is. A szerz\u0151k \u00e1ttekintik az \u00fajabb diagnosztikus \u00e9s ter\u00e1pi\u00e1s lehet\u0151s\u00e9geket, mind a biol\u00f3giai ter\u00e1pi\u00e1kat, mind az \u0151ssejtkezel\u00e9st. Az antifoszfolipid-szindr\u00f3m\u00e1ban szenved\u0151 n\u0151k terhess\u00e9ge eset\u00e9n az antithromboticus kezel\u00e9s jav\u00edtja a t\u00fal\u00e9l\u00e9s \u00e9s az eg\u00e9szs\u00e9ges gyermek sz\u00fclet\u00e9s\u00e9nek az es\u00e9lyeit. A neonatalis SLE \u2013 b\u00e1r ritk\u00e1n fordul el\u0151 \u2013 morbidit\u00e1sa \u00e9s mortalit\u00e1sa szignifik\u00e1nsan nagyobb, mint eg\u00e9szs\u00e9ges \u00fajsz\u00fcl\u00f6ttek eset\u00e9n. \u00dajabb tanulm\u00e1nyok biztat\u00f3 eredm\u00e9nyekkel szolg\u00e1lnak a neonatalis lupus profilaktikus ter\u00e1pi\u00e1val val\u00f3 kezel\u00e9se ter\u00e9n. A terhes gondoz\u00e1sa olyan centrumint\u00e9zetben javasolt ahol a sz\u00fcl\u00e9sz j\u00e1rtas a lupus v\u00e1rhat\u00f3 \u00e9s kezelhet\u0151 sz\u00f6v\u0151dm\u00e9nyeiben, lehet\u0151s\u00e9g van reumatol\u00f3giai konzult\u00e1ci\u00f3ra, valamint ahol az igen kis s\u00faly\u00fa korasz\u00fcl\u00f6ttek ell\u00e1t\u00e1sa is biztos\u00edthat\u00f3.<\/jats:p>","DOI":"10.1556\/oh.2008.28295","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T16:59:31Z","timestamp":1208797171000},"page":"723-731","source":"Crossref","is-referenced-by-count":0,"title":["Systemic lupus erythematosus and pregnancy"],"prefix":"10.1556","volume":"149","author":[{"given":"Tam\u00e1s","family":"G\u00e1ti","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Budai Irgalmasrendi K\u00f3rh\u00e1z III. Belgy\u00f3gy\u00e1szati Klinika, Reumatol\u00f3giai \u00e9s Fizioter\u00e1pi\u00e1s Tansz\u00e9ki Csoport Budapest Egry J\u00f3zsef u. 23. 1111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Pajor","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1l","family":"G\u00e9her","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Budai Irgalmasrendi K\u00f3rh\u00e1z III. Belgy\u00f3gy\u00e1szati Klinika, Reumatol\u00f3giai \u00e9s Fizioter\u00e1pi\u00e1s Tansz\u00e9ki Csoport Budapest Egry J\u00f3zsef u. 23. 1111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Nagy","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Budai Irgalmasrendi K\u00f3rh\u00e1z III. Belgy\u00f3gy\u00e1szati Klinika, Reumatol\u00f3giai \u00e9s Fizioter\u00e1pi\u00e1s Tansz\u00e9ki Csoport Budapest Egry J\u00f3zsef u. 23. 1111"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"171","volume":"2","year":"1999","journal-title":"Clin. Exp. Rheumatol."},{"volume-title":"Klinikai Reumatol\u00f3gia","year":"2005","key":"atypb2"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.clim.2005.10.016","volume":"118","year":"2006","journal-title":"Clin. 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