{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T11:40:02Z","timestamp":1709206802947},"reference-count":38,"publisher":"Akademiai Kiado Zrt.","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:p>A fetopatol\u00f3giai vizsg\u00e1lat nagy jelent\u0151s\u00e9g\u0171, hiszen egy k\u00f6vetkez\u0151 terhess\u00e9g v\u00e1llal\u00e1s\u00e1nak szempontjait szem el\u0151tt tartva az el\u0151fordult rendelleness\u00e9g ism\u00e9tl\u0151d\u00e9s\u00e9nek kock\u00e1zatait (is) hivatott meg\u00edt\u00e9lni.<jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>A szerz\u0151k tanulm\u00e1nyuk c\u00e9ljak\u00e9nt az ultrahang-diagnosztika hat\u00e9konys\u00e1g\u00e1nak a fetopatol\u00f3giai vizsg\u00e1latok eredm\u00e9nyei alapj\u00e1n t\u00f6rt\u00e9n\u0151 meg\u00edt\u00e9l\u00e9s\u00e9t, elemz\u00e9s\u00e9t hat\u00e1rozt\u00e1k meg a nagyobb prevalenci\u00e1j\u00fa fejl\u0151d\u00e9si rendelleness\u00e9gek tekintet\u00e9ben.<jats:italic>M\u00f3dszer:<\/jats:italic>Vizsg\u00e1lataik sor\u00e1n az 1995\u20132006 k\u00f6z\u00f6tt a klinik\u00e1n el\u0151fordult 683, k\u00f6zponti idegrendszert, sz\u00edv- \u00e9s \u00e9rrendszert, h\u00fagy\u00fati rendszert, csontv\u00e1zrendszert, illetve hasfalat\/mellkasfalat \u00e9rint\u0151 rendelleness\u00e9ggel j\u00e1r\u00f3 terhess\u00e9g adatait dolgozt\u00e1k fel.<jats:italic>Eredm\u00e9nyek:<\/jats:italic>Szignifik\u00e1ns k\u00fcl\u00f6nbs\u00e9g az anyai \u00e9letkor, illetve a diagn\u00f3zis fel\u00e1ll\u00edt\u00e1sakor meghat\u00e1rozhat\u00f3 geszt\u00e1ci\u00f3s kor f\u0151bb statisztikai jellemz\u0151i kapcs\u00e1n nem volt igazolhat\u00f3. A k\u00f6zponti idegrendszert, a cardiovascularis rendszert, valamint a v\u00e1zrendszert \u00e9rint\u0151 malform\u00e1ci\u00f3k egynegyed\u00e9ben, m\u00edg a h\u00fagy\u00fati, illetve hasfalat\/mellkasfalat \u00e9rint\u0151 rendelleness\u00e9gek egyhatod\u00e1ban valamilyen terhel\u0151 el\u0151zm\u00e9nyi adat fellelhet\u0151 volt. A h\u00fagy\u00fati, valamint cardiovascularis malform\u00e1ci\u00f3k fi\u00famagzatokban l\u00e9nyegesen gyakoribbak voltak, ugyanakkor a k\u00f6zponti idegrendszer, illetve a hasfal\/mellkasfal rendelleness\u00e9gei eset\u00e9n m\u00e9rs\u00e9kelt le\u00e1nyt\u00fals\u00faly volt megfigyelhet\u0151. A vizsg\u00e1lt \u00f6t rendelleness\u00e9g-csoportb\u00f3l n\u00e9gyben a post mortem vizsg\u00e1lat eredm\u00e9ny\u00e9nek teljesen megfelel\u0151 szonogr\u00e1fiai k\u00f3rism\u00e9k ar\u00e1nya 70% k\u00f6r\u00fcl vagy a felett alakult, a h\u00fagy\u00fati rendelleness\u00e9g kapcs\u00e1n azonban sz\u00e1mottev\u0151en alacsonyabbnak (38%) bizonyult. A teljes minta alapj\u00e1n a szonogr\u00e1fiai \u00e9s fetopatol\u00f3giai diagn\u00f3zisok teljes egyez\u00e9s\u00e9vel j\u00e1r\u00f3 esetek (A csoport) \u00f6sszes\u00edtett ar\u00e1nya t\u00f6bb mint 63%-nak, m\u00edg az ezekt\u0151l val\u00f3 elt\u00e9r\u00e9ssel j\u00e1r\u00f3 terhess\u00e9gek ar\u00e1nya (C csoport) 18%-nak bizonyult. Az ultrahangvizsg\u00e1lat \u00e9s a post mortem vizsg\u00e1lat sor\u00e1n nyert diagn\u00f3zisok r\u00e9szleges egyez\u00e9s\u00e9vel j\u00e1r\u00f3 esetek (B csoport) ar\u00e1nya szint\u00e9n 18%-nak bizonyult.<jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>A gyakran k\u00f6vetkezm\u00e9nyesen kevesebb magzatv\u00edzzel j\u00e1r\u00f3 h\u00fagy\u00fati fejl\u0151d\u00e9si rendelleness\u00e9gek eset\u00e9n genetikai centrumban t\u00f6rt\u00e9n\u0151 (ak\u00e1r t\u00f6bbsz\u00f6ri) szonogr\u00e1fiai vizsg\u00e1lat indokolt. Mivel az omphalokele \u00e9s a kromosz\u00f3ma-rendelleness\u00e9gek t\u00e1rsul\u00e1si hajlama ismert, annak t\u00fckr\u00e9ben, hogy az omphalokel\u00e9s esetek egy r\u00e9sze gastroschisisk\u00e9nt ker\u00fcl k\u00f3rism\u00e9z\u00e9sre, tan\u00e1csos lehet a kromosz\u00f3mavizsg\u00e1lat elv\u00e9gz\u00e9se az ultrahangvizsg\u00e1lattal gastroschisisk\u00e9nt diagnosztiz\u00e1lt esetekben is. VSD esetei kapcs\u00e1n javasolt a magasabb kock\u00e1zat\u00fa terhess\u00e9gekben az echokardiogr\u00e1fi\u00e1s vizsg\u00e1lat minden konkr\u00e9t \u00e1ltal\u00e1nos ultrahang-diagnosztikai elt\u00e9r\u00e9s n\u00e9lk\u00fcli elv\u00e9gz\u00e9se.<\/jats:p>","DOI":"10.1556\/oh.2008.28311","type":"journal-article","created":{"date-parts":[[2008,8,20]],"date-time":"2008-08-20T02:42:46Z","timestamp":1219200166000},"page":"1645-1652","source":"Crossref","is-referenced-by-count":1,"title":["Common malformations in fetopathological investigations between 1995 and 2006. 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