{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:45:58Z","timestamp":1747212358808},"reference-count":39,"publisher":"Akademiai Kiado Zrt.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:p>Az els\u0151dleges m\u00e1jr\u00e1k az \u00f6t\u00f6dik leggyakoribb daganat vil\u00e1gszerte. A primer m\u00e1jr\u00e1kok 85\u201390%-a hepatocellularis carcinoma. F\u00f6ldrajzi eloszl\u00e1sa jellegzetes, egyes n\u00e9pcsoportokban is elt\u00e9r\u0151. F\u00e9rfiakban gyakoribb, mint n\u0151kben. 70\u201390%-ban id\u00fclt m\u00e1jbetegs\u00e9g vagy cirrhosis talaj\u00e1n alakul ki. A hepatitis B-, C-v\u00edrus-fert\u0151z\u00e9s \u00e9s az aflatoxinszennyezetts\u00e9g a m\u00e1jr\u00e1kok 80%-\u00e1\u00e9rt felel\u0151s. Kialakul\u00e1sa t\u00f6bbl\u00e9pcs\u0151s folyamat, molekul\u00e1ris h\u00e1tter\u00e9r\u0151l egyre t\u00f6bb ismerettel rendelkez\u00fcnk. A genetikai \u00e9s epigenetikai elt\u00e9r\u00e9sek a sejtprolifer\u00e1ci\u00f3t serkent\u0151 medi\u00e1torokat aktiv\u00e1lj\u00e1k (onkog\u00e9nek), a szaporod\u00e1st g\u00e1tl\u00f3 medi\u00e1torokat hat\u00e1stalan\u00edtj\u00e1k (tumorszuppresszor feh\u00e9rj\u00e9k), amely auton\u00f3m sejtprolifer\u00e1ci\u00f3t eredm\u00e9nyez. A telomera k\u00f3ros m\u0171k\u00f6d\u00e9s okozta kromosz\u00f3mainstabilit\u00e1s, a n\u00f6veked\u00e9s\u00e9ben g\u00e1tolt k\u00f6rnyezet, a mikro- \u00e9s makrok\u00f6rnyezet megv\u00e1ltoz\u00e1sa seg\u00edti a malignusan transzform\u00e1lt sejtek terjed\u00e9s\u00e9t. A folyamatok pontos megismer\u00e9se \u00e9s meg\u00e9rt\u00e9se az id\u00fclt m\u00e1jbetegek, m\u00e1jzsugorban szenved\u0151k sz\u0171r\u00e9s\u00e9t, a HCC megel\u0151z\u00e9s\u00e9t \u00e9s a kezel\u00e9st seg\u00edtheti a j\u00f6v\u0151ben.<\/jats:p>","DOI":"10.1556\/oh.2008.28313","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T00:07:17Z","timestamp":1205539637000},"page":"541-548","source":"Crossref","is-referenced-by-count":25,"title":["Epidemiology, risk factors and molecular pathogenesis of primary liver cancer"],"prefix":"10.1556","volume":"149","author":[{"given":"Krisztina","family":"Hagym\u00e1si","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Tulassay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.amjmed.2006.11.020","volume":"120","year":"2007","journal-title":"Am. J. Med."},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","volume":"132","year":"2007","journal-title":"Gastroenterology"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrc1934","volume":"6","year":"2006","journal-title":"Nature Rev. Cancers"},{"key":"atypb4","first-page":"107","volume":"50","year":"2006","journal-title":"Magyar Onkol\u00f3gia"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1038\/sj.onc.1209560","volume":"25","year":"2006","journal-title":"Oncogene"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpg.2004.10.004","volume":"19","year":"2005","journal-title":"Best Practice Res. Clin. Gastroent."},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bpg.2006.07.002","volume":"21","year":"2007","journal-title":"Best Practice Res. Clin. Gastroent."},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1111\/j.1872-034X.2007.00168.x","volume":"37","year":"2007","journal-title":"Hepatol. Res."},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/MOG.0b013e3280ec5113","volume":"23","year":"2007","journal-title":"Curr. Op. Gastroenterol."},{"key":"atypb10","first-page":"612","volume":"38","year":"2007","journal-title":"Arch. Med. Sci."},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.canlet.2005.08.031","volume":"240","year":"2006","journal-title":"Cancer Letters"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3748\/wjg.v13.i1.74","volume":"13","year":"2007","journal-title":"W. J. Gastroenterol."},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1038\/sj.onc.1209547","volume":"25","year":"2006","journal-title":"Oncogene"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-2893.2004.00521.x","volume":"11","year":"2004","journal-title":"J. Viral Hepatitis"},{"key":"atypb15","first-page":"77","volume":"24","year":"2004","journal-title":"Seminars Liv. Dis."},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00535-006-1774-5","volume":"41","year":"2006","journal-title":"J. Gastroenterol."},{"key":"atypb17","first-page":"875","volume":"34","year":"2005","journal-title":"J. Clin. Virol."},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2741\/2060","volume":"12","year":"2007","journal-title":"Front. Biosci."},{"key":"atypb19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1440-1746.2006.04669.x","volume":"22","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncpendmet0505","volume":"3","year":"2007","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1309\/RTPM1PY6YGBL2G2R","volume":"128","year":"2007","journal-title":"Am. J. Clin. Pathol."},{"key":"atypb22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cgh.2005.12.007","volume":"4","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"atypb23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jhep.2007.03.015","volume":"47","year":"2007","journal-title":"J. Hepatol."},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1572-0241.2003.07222.x","volume":"98","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"atypb25","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1002\/ijc.22267","volume":"119","year":"2006","journal-title":"Int. J. Cancer"},{"key":"atypb26","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1038\/sj.onc.1208308","volume":"24","year":"2005","journal-title":"Oncogene"},{"key":"atypb27","first-page":"5021","volume":"63","year":"2003","journal-title":"Cancer Res."},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00534-005-1054-4","volume":"13","year":"2006","journal-title":"J. Hepato-Biliary-Pancreatic Surgery"},{"key":"atypb29","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/S0399-8320(06)73554-0","volume":"30","year":"2006","journal-title":"Gastroenterol. Clin. Biolog."},{"key":"atypb30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1440-1746.2005.04043.x","volume":"21","year":"2006","journal-title":"J. Gastroent. Hepatol."},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1478-3231.2006.01409.x","volume":"27","year":"2007","journal-title":"Liver Int."},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ejca.2007.01.004","volume":"43","year":"2007","journal-title":"Eur. J. Cancer"},{"key":"atypb33","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1038\/sj.onc.1210279","volume":"26","year":"2007","journal-title":"Oncogene"},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00795-006-0339-2","volume":"39","year":"2006","journal-title":"Med. Mol. Morphology"},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1038\/sj.onc.1209556","volume":"25","year":"2006","journal-title":"Oncogene"},{"key":"atypb36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1385\/SCR:1:3:261","volume":"1","year":"2005","journal-title":"Stem Cells Rev."},{"key":"atypb37","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1053\/j.gastro.2007.01.045","volume":"132","year":"2007","journal-title":"Gastroenterology"},{"key":"atypb38","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/hep.20822","volume":"42","year":"2005","journal-title":"Hepatology"},{"key":"atypb39","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3748\/wjg.v13.i7.985","volume":"13","year":"2007","journal-title":"W. J. Gastroenterol."}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/149\/12\/article-p541.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/149\/12\/article-p541.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T10:14:21Z","timestamp":1590574461000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/149\/12\/article-p541.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,1]]},"references-count":39,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.1556\/oh.2008.28313","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,1]]}}}