{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T04:51:08Z","timestamp":1648875068364},"reference-count":44,"publisher":"Akademiai Kiado Zrt.","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:p>Az \u0151ssejtek \u00f6nmeg\u00faj\u00edt\u00f3 k\u00e9pess\u00e9g\u0171, egy vagy t\u00f6bb differenci\u00e1lt sejtt\u00edpus l\u00e9trehoz\u00e1s\u00e1ra k\u00e9pes sejtek. Multipotensek, k\u00f6nny\u0171 kinyer\u00e9s\u00fck r\u00e9v\u00e9n a sejt- \u00e9s g\u00e9nter\u00e1pia c\u00e9lpontjai lehetnek a j\u00f6v\u0151ben. Feln\u0151tt mesenchymalis, neuronalis, epidermalis, haematopoeticus \u0151ssejtek alkalmaz\u00e1sa el\u0151ny\u00f6s lehet sz\u00edv- (myocardialis infarctus), csont- (osteoarthritis), idegbetegs\u00e9gek (Parkinson-, Alzheimer-k\u00f3r), hematol\u00f3giai k\u00f3rk\u00e9pek (haemophilia, thrombocytopenia) kezel\u00e9s\u00e9ben. A szerz\u0151k a gyomor-b\u00e9l rendszer betegs\u00e9geiben t\u00f6rt\u00e9nt alkalmaz\u00e1sukkal kapcsolatos kis-, de n\u00f6vekv\u0151 sz\u00e1m\u00fa ismereteket tekintik \u00e1t. A haematopoeticus \u0151ssejt\u00e1t\u00fcltet\u00e9s eredm\u00e9nyes volt kezel\u00e9sre nem reag\u00e1l\u00f3 Crohn-betegekben, coeliaki\u00e1s betegek bizonyos csoportj\u00e1ban. A m\u00e1j k\u00f6t\u0151sz\u00f6vetes elfajul\u00e1s\u00e1nak megel\u0151z\u00e9s\u00e9re mesenchymalis \u0151ssejteket alkalmaztak sikerrel. A haematopoeticus \u0151ssejt-transzplant\u00e1ci\u00f3s kezel\u00e9sre nem reag\u00e1l\u00f3 autoimmun gyomor-b\u00e9l rendszeri betegs\u00e9gekben \u00edg\u00e9retes lehet\u0151s\u00e9g lehet. Tov\u00e1bbi ter\u00e1pi\u00e1s c\u00e9lpontok lehetnek az autoimmun m\u00e1jbetegs\u00e9gek: autoimmun hepatitis, primer biliaris cirrhosis, primer sclerotiz\u00e1l\u00f3 cholangitis. J\u00f3l tervezett multicentrikus prospekt\u00edv vizsg\u00e1latok sz\u00fcks\u00e9gesek az esettanulm\u00e1nyok \u00e9s a kissz\u00e1m\u00fa klinikai vizsg\u00e1lat sor\u00e1n tapasztalt lehet\u0151s\u00e9gek bizony\u00edt\u00e1s\u00e1ra.<\/jats:p>","DOI":"10.1556\/oh.2008.28400","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T12:42:54Z","timestamp":1216212174000},"page":"1449-1455","source":"Crossref","is-referenced-by-count":1,"title":["Stem cell transplantation in the treatment of gastrointestinal diseases"],"prefix":"10.1556","volume":"149","author":[{"given":"Krisztina","family":"Hagym\u00e1si","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Tulassay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"1327","volume":"146","year":"2005","journal-title":"Orv. Hetil."},{"key":"atypb2","first-page":"921","volume":"18","year":"2002","journal-title":"Orv. Hetil."},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.ejca.2006.01.036","volume":"42","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"atypb4","first-page":"6","volume":"2","year":"2006","journal-title":"AGA Perspectives"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1038\/sj.onc.1205604","volume":"21","year":"2002","journal-title":"Oncogene"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nature04956","volume":"441","year":"2006","journal-title":"Nature"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3748\/wjg.v12.i3.363","volume":"12","year":"2006","journal-title":"W. J. Gastroent."},{"key":"atypb8","first-page":"2263","volume":"144","year":"2003","journal-title":"Orv. Hetil."},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJMoa3461002","volume":"346","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/00000441-198708000-00002","volume":"294","year":"1987","journal-title":"Am. J. Med. Sci."},{"key":"atypb11","first-page":"226","volume":"1","year":"2006","journal-title":"Hematology"},{"key":"atypb12","first-page":"205","volume":"1","year":"2006","journal-title":"Hematology"},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1093\/annonc\/mdl044","volume":"17","year":"2006","journal-title":"Ann. Oncol."},{"key":"atypb14","first-page":"390","volume":"1","year":"2006","journal-title":"Hematology"},{"key":"atypb15","first-page":"398","volume":"1","year":"2006","journal-title":"Hematology"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3324\/haematol.11185","volume":"92","year":"2007","journal-title":"Haematologica"},{"key":"atypb17","first-page":"337","volume":"3","year":"2004","journal-title":"Magyar Tudom\u00e1ny"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/CCO.0b013e3282f5100b","volume":"20","year":"2008","journal-title":"Curr. Op. Oncol."},{"key":"atypb19","first-page":"595","volume":"141","year":"2000","journal-title":"Orv. Hetil."},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-2036.2007.03478.x","volume":"26","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.autrev.2005.03.003","volume":"4","year":"2005","journal-title":"Autoimmun. Rev."},{"key":"atypb22","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1002\/art.22256","volume":"54","year":"2006","journal-title":"Arth. Rheum."},{"key":"atypb23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/ar2128","volume":"9","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1182\/blood-2002-07-2122","volume":"101","year":"2003","journal-title":"Blood"},{"key":"atypb25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00384-003-0490-3","volume":"18","year":"2003","journal-title":"Int. J. Colorectal Dis."},{"key":"atypb26","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1007\/s10350-005-0052-6","volume":"48","year":"2005","journal-title":"Dis. Colon Rectum"},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1053\/j.gastro.2004.11.051","volume":"128","year":"2005","journal-title":"Gastroenterology"},{"key":"atypb28","first-page":"6665","volume":"12","year":"2006","journal-title":"is it time?; W. J. Gastroenterol."},{"key":"atypb29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/gut.2007.128694","volume":"57","year":"2008","journal-title":"Gut"},{"key":"atypb30","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1097\/01.TP.0000062540.29757.E9","volume":"75","year":"2003","journal-title":"Transplantation"},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/sj.bmt.1703103","volume":"28","year":"2001","journal-title":"Bone Marrow Transplant."},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1542\/peds.2006-1402","volume":"120","year":"2007","journal-title":"Pediatrics"},{"key":"atypb33","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1182\/blood-2006-08-042820","volume":"109","year":"2007","journal-title":"Blood"},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.3748\/wjg.v11.i22.3431","volume":"11","year":"2005","journal-title":"W. J. Gastroenterol."},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1016\/j.transproceed.2006.08.132","volume":"38","year":"2006","journal-title":"Transplant. Proc."},{"key":"atypb36","first-page":"459","volume":"10","year":"2007","journal-title":"Arch. Iran. Med."},{"key":"atypb37","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1634\/stemcells.2007-0056","volume":"25","year":"2007","journal-title":"Stem Cells"},{"key":"atypb38","first-page":"323","volume":"12","year":"2004","journal-title":"Oncol. Rep."},{"key":"atypb39","first-page":"341","volume":"7","year":"2001","journal-title":"Oncol. Report"},{"key":"atypb40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/sj.bmt.1703811","volume":"31","year":"2003","journal-title":"Bone Marrow Transplant."},{"key":"atypb41","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1182\/blood-2005-10-3945","volume":"107","year":"2006","journal-title":"Blood"},{"key":"atypb42","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1080\/1042819031000123456","volume":"44","year":"2003","journal-title":"Leuk. Lymphoma"},{"key":"atypb43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2141.2006.06371.x","volume":"136","year":"2007","journal-title":"Br. J. Haematol."},{"key":"atypb44","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.dld.2007.04.009","volume":"39","year":"2007","journal-title":"Dig. Liver Dis."}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/149\/31\/article-p1449.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/149\/31\/article-p1449.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T10:17:11Z","timestamp":1590574631000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/149\/31\/article-p1449.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,1]]},"references-count":44,"journal-issue":{"issue":"31"},"URL":"https:\/\/doi.org\/10.1556\/oh.2008.28400","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,1]]}}}