{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:02:27Z","timestamp":1649203347261},"reference-count":48,"publisher":"Akademiai Kiado Zrt.","issue":"28","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:p>A szerz\u0151 a foly\u00f3irat-refer\u00e1l\u00f3 rovat \u201e\u00c9rendothel-funkci\u00f3zavar, oxidat\u00edv stressz\u201d t\u00e1rgyk\u00f6rrel val\u00f3 b\u0151v\u00edt\u00e9s\u00e9nek fontoss\u00e1g\u00e1t szakmailag \u2013 a t\u00e9ma nagys\u00e1g\u00e1ra val\u00f3 tekintettel \u2013 n\u00e9h\u00e1ny \u00f6nk\u00e9nyesen kiemelt k\u00e9rd\u00e9sk\u00f6r kibont\u00e1s\u00e1val t\u00e1masztja al\u00e1: Az endothelium a bels\u0151 k\u00f6rnyezet \u00e1lland\u00f3s\u00e1g\u00e1t, integrit\u00e1s\u00e1t vigy\u00e1zza, azt k\u00fcl\u00f6nb\u00f6z\u0151 anyagok termel\u00e9s\u00e9vel-elv\u00e1laszt\u00e1s\u00e1val, azoknak egyens\u00falyban tart\u00e1s\u00e1val biztos\u00edtja. Ha az erek belfel\u00fclet\u00e9t, intim\u00e1j\u00e1t \u00e9r\u0151 mechanikai, fizikai, k\u00e9miai, mikrobiol\u00f3giai, immunol\u00f3giai, genetikai k\u00e1ros\u00edt\u00f3 t\u00e9yez\u0151k \u2013 vagy azok valamelyik\u00e9nek kombin\u00e1ci\u00f3ja \u2013 ellen foganatos\u00edtott v\u00e1laszreakci\u00f3 folyam\u00e1n megbomlik az egyens\u00faly az endothelium termelte vasoconstrictorok \u00e9s vasodilatatorok, a n\u00f6veked\u00e9si faktorok \u00e9s azok g\u00e1tl\u00f3i, a proinflamm\u00e1torok \u00e9s antiinflamm\u00e1torok, a protrombotikus \u00e9s fibrinolitikus t\u00e9nyez\u0151k k\u00f6z\u00f6tt, endothel-m\u0171k\u00f6d\u00e9szavarr\u00f3l besz\u00e9l\u00fcnk. Az id\u00fclt \u00e9rbetegs\u00e9g, az atherosclerosis ind\u00edt\u00f3 esem\u00e9nye az erek hatalmas belfel\u00fclet\u00e9n, az endothelsejtekben megy v\u00e9gbe, ezt nevezz\u00fck \n <jats:italic>endotheldiszfunkci\u00f3nak<\/jats:italic>\n . Az \u00e9rpatog\u00e9n t\u00e9nyez\u0151k, a rizik\u00f3faktorok mindegyike \n <jats:italic>endothel-m\u0171k\u00f6d\u00e9szavar<\/jats:italic>\n , endotheldiszfunkci\u00f3 induk\u00e1l\u00e1s\u00e1val vezet id\u00fclt (cardio)vascularis megbeteged\u00e9shez. Az \u00e9lettani oxidat\u00edv metabolizmus sor\u00e1n v\u00e9gbemen\u0151 fiziol\u00f3gi\u00e1s szabad gy\u00f6k\u00f6s folyamatok \u2013 a v\u00e9dekez\u0151-kompenz\u00e1l\u00f3 endog\u00e9n antioxidat\u00edv faktorok kimer\u00fcl\u00e9sekor \u2013 \n <jats:italic>oxidat\u00edv stresszt<\/jats:italic>\n , a vesz\u00e9lyeztet\u0151 t\u00e9nyez\u0151k okozta endothel-m\u0171k\u00f6d\u00e9szavart okoznak. Nyomat\u00e9kosan kiemelend\u0151 a \u201ekauz\u00e1lis\u201d, intracellul\u00e1risan, mitokondri\u00e1lisan hat\u00f3 antioxid\u00e1nsok (sztatinok, angiotenzinkonvert\u00e1l\u00f3enzim-g\u00e1tl\u00f3k, angiotenzinreceptor-blokkol\u00f3k, acetilszalicilsav, a harmadik gener\u00e1ci\u00f3s b\u00e9ta-blokkol\u00f3k) ter\u00e1pi\u00e1s, prevent\u00edv ter\u00e1pi\u00e1s fontoss\u00e1ga, a hum\u00e1n \u00e9rrendszer \u00e9lettani, k\u00f3r\u00e9lettani, ter\u00e1pi\u00e1s konszubsztancialit\u00e1s\u00e1nak, egyl\u00e9nyeg\u0171s\u00e9g\u00e9nek \u00e9s az endotheldiszfunkci\u00f3 sziszt\u00e9m\u00e1s jelleg\u00e9nek, az \u00e9rrendszeri esem\u00e9nyl\u00e1ncolat prevent\u00edv ter\u00e1pi\u00e1s jelent\u0151s\u00e9g\u00e9nek kulcsfontoss\u00e1ga. Az oxidat\u00edv stressz, a konszekut\u00edv endotheldiszfunkci\u00f3 ter\u00fclet\u00e9n v\u00e9gbement hatalmas fejl\u0151d\u00e9s a klinikai l\u00e1t\u00e1sm\u00f3dot alapjaiban \u00e1talak\u00edt\u00f3 momentum.<\/jats:p>","DOI":"10.1556\/oh.2008.28402","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T12:48:47Z","timestamp":1215694127000},"page":"1323-1327","source":"Crossref","is-referenced-by-count":1,"title":["Vascular endothelial dysfunction, oxidative stress \u2013 a new topic within the referal section of Orvosi Hetilap"],"prefix":"10.1556","volume":"149","author":[{"given":"Tam\u00e1s","family":"Fischer","sequence":"first","affiliation":[{"name":"1 Budapest K\u00f6rvas\u00fat sor 75\/B 1158"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1161\/hc0502.104540","volume":"105","year":"2002","journal-title":"Circulation"},{"key":"atypb2","first-page":"363","volume":"111","year":"2005","journal-title":"Cardiac events. 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