{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:07:01Z","timestamp":1783487221882,"version":"3.55.0"},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:p>A szel\u00e9n n\u00e9lk\u00fcl\u00f6zhetetlen nyomelem, amely antioxid\u00e1ns hat\u00e1sa r\u00e9v\u00e9n l\u00e9nyeges az immun- \u00e9s az endokrin rendszer m\u0171k\u00f6d\u00e9s\u00e9ben. A pajzsmirigy hormonszint\u00e9zise sor\u00e1n k\u00e9pz\u0151d\u0151 szabad gy\u00f6k\u00f6knek szerep\u00fck lehet a thyreoidea autoimmun betegs\u00e9geiben. \n <jats:italic>A vizsg\u00e1lat c\u00e9lja <\/jats:italic>\n az volt, hogy meghat\u00e1rozz\u00e1k, a szel\u00e9nkezel\u00e9s hat-e a pajzsmirigy-peroxid\u00e1z, a tireoglobulin elleni antitestek szintj\u00e9re \u00e9s az antioxid\u00e1ns st\u00e1tusra. \n <jats:italic>M\u00f3dszer:<\/jats:italic>\n Sz\u00e1zharminck\u00e9t autoimmun thyreoiditises betegben kett\u0151s vakm\u00f3dszerrel tesztelt\u00e9k a szel\u00e9n hat\u00e1sait. Mindk\u00e9t csoportban alkalmaztak L-tiroxin-szubsztit\u00faci\u00f3s kezel\u00e9st, \u00edgy a TSH-szint az \u00e9lettani tartom\u00e1nyban maradt. A kezelt csoportba 70 beteg (68 n\u0151, \u00e1tlag\u00e9letkor 41,4 \u00b1 9,5 \u00e9v), a placebocsoportba 62 beteg (61 n\u0151, \u00e1tlag\u00e9letkor 42,7 \u00b1 8,3 \u00e9v) tartozott. A TSH, az fT4, az fT3 \u00e9s az antitestek m\u00e9r\u00e9s\u00e9t kemilumineszcens technik\u00e1val v\u00e9gezt\u00e9k. A teljes antioxid\u00e1ns-kapacit\u00e1st Randox kittel, a sz\u00e9rumszel\u00e9nszintet atomabszorpci\u00f3s m\u00f3dszerrel hat\u00e1rozt\u00e1k meg. A kezel\u00e9s sor\u00e1n a vizsg\u00e1lt betegek 2 \u00d7 100 \u00b5g L-szel\u00e9n-metionin tablett\u00e1t kaptak. A betegek klinikai \u00e9s laborat\u00f3riumi vizsg\u00e1lat\u00e1t h\u00e1romhavonta v\u00e9gezt\u00e9k egy \u00e9ven \u00e1t. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A szel\u00e9nszint a betegek sz\u00e9rum\u00e1ban l\u00e9nyegesen alacsonyabb volt, mint az eg\u00e9szs\u00e9ges kontrollokban. Az fT3\/fT4 ar\u00e1ny magasabb volt a szel\u00e9nnel kezeltekben, mint a placebocsoportban. A szel\u00e9n hat\u00e1s\u00e1ra az autoantitestek (f\u0151leg a pajzsmirigy-peroxid\u00e1zenzim elleni antitestek) titere szignifik\u00e1nsan cs\u00f6kkent a megfigyel\u00e9si id\u0151 v\u00e9g\u00e9re. Inverz \u00f6sszef\u00fcgg\u00e9st tal\u00e1ltak az antioxid\u00e1ns st\u00e1tus \u00e9s a pajzsmirigy-peroxid\u00e1zenzim elleni antitestek titere k\u00f6z\u00f6tt. A pajzsmirigy t\u00e9rfogata a kezelt betegekben nem cs\u00f6kkent jelent\u0151sen. Mell\u00e9khat\u00e1st a kezel\u00e9s sor\u00e1n nem tapasztaltak. \n <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n A szel\u00e9nkezel\u00e9s autoantitest-k\u00e9pz\u00e9st g\u00e1tl\u00f3 hat\u00e1sa miatt alkalmas az autoimmun thyreoiditises betegek kezel\u00e9s\u00e9re.<\/jats:p>","DOI":"10.1556\/oh.2008.28408","type":"journal-article","created":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T13:23:07Z","timestamp":1213881787000},"page":"1227-1232","source":"Crossref","is-referenced-by-count":22,"title":["The effect of selenium therapy on autoimmune thyroiditis"],"prefix":"10.1556","volume":"149","author":[{"given":"Csaba","family":"Bal\u00e1zs","sequence":"first","affiliation":[{"name":"1 Budai Irgalmasrendi K\u00f3rh\u00e1z Belgy\u00f3gy\u00e1szat Budapest Frankel Le\u00f3 u. 17\u201319. 1027"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1677\/joe.1.05971","volume":"184","year":"2005","journal-title":"J. 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