{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T19:29:20Z","timestamp":1694633360083},"reference-count":15,"publisher":"Akademiai Kiado Zrt.","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:p>A k\u00f6penysejtes lymphoma (MCL) m\u00e9rs\u00e9kelten agressz\u00edv betegs\u00e9g, amely kemoimmunoter\u00e1pi\u00e1val nem gy\u00f3gy\u00edthat\u00f3. A medi\u00e1n t\u00fal\u00e9l\u00e9s r\u00f6vid, mintegy h\u00e1rom \u00e9v. T\u00f6bbnyire el\u0151rehaladott st\u00e1diumban ismerik fel. A csontvel\u0151 a betegek fel\u00e9ben, a gastrointestinalis traktus a negyed\u00fckben \u00e9rintett, leuk\u00e9mi\u00e1s transzform\u00e1ci\u00f3 25%-ban fordul el\u0151. A malignus sejtek B-sejt-eredet\u0171ek \u00e9s CD5-pozit\u00edvak, jellemz\u0151 a ciklin-D1-expresszi\u00f3. A kezel\u00e9sben kombin\u00e1lt kemoter\u00e1pia, kemoimmunoter\u00e1pia, valamint autol\u00f3g perif\u00e9ri\u00e1s \u0151ssejt- (\u00e9s allog\u00e9n) transzplant\u00e1ci\u00f3 j\u00f6het sz\u00f3ba. A bemutatott k\u00e9t beteg eset\u00e9ben, az optim\u00e1lis kezdeti ter\u00e1pia hi\u00e1nya ellen\u00e9re, tart\u00f3s t\u00fal\u00e9l\u00e9s volt el\u00e9rhet\u0151. Az alkalmazott komplex kezel\u00e9s (kemoimmunoter\u00e1pia, sug\u00e1rkezel\u00e9s, seb\u00e9szi beavatkoz\u00e1s, autol\u00f3g \u0151ssejt-transzplant\u00e1ci\u00f3) ugyanis 80, illetve 90 h\u00f3napig tart\u00f3 t\u00fal\u00e9l\u00e9st eredm\u00e9nyezett. A k\u00e9t beteg k\u00f3rt\u00f6rt\u00e9net\u00e9nek ismertet\u00e9se mellett a szerz\u0151k \u00e1ttekintik a k\u00f6penysejtes lymphoma korszer\u0171 kezel\u00e9s\u00e9nek mai lehet\u0151s\u00e9geit.<\/jats:p>","DOI":"10.1556\/oh.2008.28411","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T12:42:54Z","timestamp":1216212174000},"page":"1471-1474","source":"Crossref","is-referenced-by-count":0,"title":["Mantle cell lymphoma: case report"],"prefix":"10.1556","volume":"149","author":[{"given":"Leon\u00f3ra","family":"M\u00e9hes","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum Hematol\u00f3giai Tansz\u00e9k, II. 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