{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:21:50Z","timestamp":1761196910936},"reference-count":42,"publisher":"Akademiai Kiado Zrt.","issue":"51","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:p>Az Alzheimer-dementia progressz\u00edv neurodegenerat\u00edv betegs\u00e9g, amelynek progresszi\u00f3j\u00e1t a jelenleg alkalmazott kezel\u00e9sek a betegs\u00e9g korai szakasz\u00e1ban lass\u00edthatj\u00e1k. Vizsg\u00e1latainkkal olyan biol\u00f3giai markereket kerest\u00fcnk, amelyek \u00e9rz\u00e9kenyek a betegs\u00e9g prodromalis \u00e9s korai szakasz\u00e1ban. A diagnosztikai rutinvizsg\u00e1latok mellett neuropszichol\u00f3giai tesztet, auditoros kiv\u00e1ltottv\u00e1lasz-vizsg\u00e1latot \u00e9s speci\u00e1lis laborat\u00f3riumi teszteket v\u00e9gezt\u00fcnk Alzheimer-betegs\u00e9gben, vascularis dementi\u00e1ban, enyhe kognit\u00edv zavarban \u00e9s depresszi\u00f3ban eg\u00e9szs\u00e9ges kontrollhoz hasonl\u00edtva. A p\u00e1ros\u00edtott asszoci\u00e1ci\u00f3s tanul\u00e1s mindegyik betegcsoportban k\u00f3ros volt, depresszi\u00f3ban reverz\u00edbilisnek l\u00e1tszott. Az auditoros kiv\u00e1ltott P300 komponens latenci\u00e1ja enyhe kognit\u00edv zavarban \u00e9s dementi\u00e1ban megn\u0151tt. A sz\u00e9rumban a paraoxon\u00e1zaktivit\u00e1s cs\u00f6kkent, az agy-gerincvel\u0151i folyad\u00e9kban az N\u03b5(\u03b3-glutamil)lizin-izodipeptid koncentr\u00e1ci\u00f3ja emelkedett mindk\u00e9t dementiacsoportban. Enyhe kognit\u00edv zavarban a p\u00e1ros\u00edtott asszoci\u00e1ci\u00f3s tanul\u00e1si teszt \u00e9s a P300 jellegzetes v\u00e1ltoz\u00e1sa az Alzheimer-dementia kialakul\u00e1s\u00e1nak nagyobb kock\u00e1zat\u00e1t jelzi. A paraoxon\u00e1zaktivit\u00e1s \u00e9s az izodipeptidkoncentr\u00e1ci\u00f3 v\u00e1ltoz\u00e1sa \u00e9rz\u00e9keny marker lehet a neurodegenerat\u00edv k\u00f3rfolyamatok kimutat\u00e1s\u00e1ra. Az eml\u00edtett vizsg\u00e1latok egy\u00fcttes alkalmaz\u00e1sa seg\u00edts\u00e9get ny\u00fajthat az Alzheimer-dementia korai felismer\u00e9s\u00e9ben \u00e9s el\u0151rejelz\u00e9s\u00e9ben.<\/jats:p>","DOI":"10.1556\/oh.2008.28429","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T03:33:58Z","timestamp":1228966438000},"page":"2433-2440","source":"Crossref","is-referenced-by-count":4,"title":["The early diagnosis and differential diagnosis of Alzheimer\u2019s disease with clinical methods"],"prefix":"10.1556","volume":"149","author":[{"given":"Anik\u00f3","family":"\u00c9gerh\u00e1zi","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Pszichi\u00e1triai Tansz\u00e9k Debrecen Nagyerdei krt. 98. 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00019442-200407000-00001","volume":"12","year":"2004","journal-title":"Am. 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