{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T06:11:01Z","timestamp":1648966261726},"reference-count":13,"publisher":"Akademiai Kiado Zrt.","issue":"41","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:p>A plazmasejtes leuk\u00e9mia a myeloma multiplex ritka \u00e9s agressz\u00edv megjelen\u00e9si form\u00e1ja. Kezel\u00e9se megoldatlan, \u00e9s k\u00fcl\u00f6n\u00f6sen a szekunder plazmasejtes leuk\u00e9mi\u00e1k eset\u00e9n v\u00e1rhat\u00f3 gyors progresszi\u00f3. A szekunder form\u00e1ban ugyanis t\u00f6bbnyire intenz\u00edv kemoter\u00e1pi\u00e1ban r\u00e9szes\u00fclt myelom\u00e1s betegekben termin\u00e1lisan k\u00f6vetkezik be a leuk\u00e9mi\u00e1s transzform\u00e1ci\u00f3, m\u00edg a primer esetekben m\u00e1r a diagn\u00f3zis idej\u00e9n kimutathat\u00f3k a plazmasejtes leuk\u00e9mia t\u00fcnetei. A szerz\u0151k nem szekretoros myeloma multiplex miatt perif\u00e9ri\u00e1s autol\u00f3g \u0151ssejt-transzplant\u00e1ci\u00f3n \u00e1tesett plazmasejtes leuk\u00e9mi\u00e1s beteg\u00fck kezel\u00e9s\u00e9t ismertetik. A bortezomib (proteasz\u00f3mag\u00e1tl\u00f3), a doxorubicin \u00e9s a dexamethason kombin\u00e1ci\u00f3ja (PAD-protokoll) komplett remisszi\u00f3t \u00e9s kilenc h\u00f3napos t\u00fal\u00e9l\u00e9st eredm\u00e9nyezett. A t\u00f6bbnyire betegismertet\u00e9seken alapul\u00f3 irodalmi adatok szerint a PAD-protokoll, saj\u00e1t tapasztalatunkhoz hasonl\u00f3an, plazmasejtes leuk\u00e9mi\u00e1ban is hat\u00e9kony \u00e9s j\u00f3l toler\u00e1lhat\u00f3. Autol\u00f3g \u00e9s\/vagy allog\u00e9n transzplant\u00e1ci\u00f3val kombin\u00e1lva a betegek t\u00fal\u00e9l\u00e9s\u00e9nek tov\u00e1bbi javul\u00e1sa v\u00e1rhat\u00f3.<\/jats:p>","DOI":"10.1556\/oh.2008.28432","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T14:16:22Z","timestamp":1223475382000},"page":"1957-1959","source":"Crossref","is-referenced-by-count":4,"title":["Effective PAD (bortezomib, doxorubicine, dexamethasone) treatment of a patient with plasma cell leukaemia developed after autologous stem cell transplantation"],"prefix":"10.1556","volume":"149","author":[{"given":"B\u00e9la","family":"Telek","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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