{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T20:18:59Z","timestamp":1649017139624},"reference-count":31,"publisher":"Akademiai Kiado Zrt.","issue":"41","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:p>A coeliakia olyan autoimmun enteropathia, amelyet a genetikailag prediszpon\u00e1lt egy\u00e9nekben a gabonaf\u00e9l\u00e9k glut\u00e9nje ind\u00edt el. A betegs\u00e9get sok\u00e1ig gyermekkori betegs\u00e9gnek tartott\u00e1k, mivel a klinikai t\u00fcnetek a glut\u00e9n \u00e9trendbe val\u00f3 be\u00e9p\u00edt\u00e9sekor jelentkeztek. A\u00a0coeliaki\u00e1ra specifikus szerol\u00f3giai markerek elterjed\u00e9se megv\u00e1ltoztatta a k\u00f3rk\u00e9p epidemiol\u00f3gi\u00e1j\u00e1val \u00e9s t\u00fcnettan\u00e1val kapcsolatos ismereteket. A diagnosztika neh\u00e9zs\u00e9ge abb\u00f3l ad\u00f3dik, hogy a glut\u00e9nszenzit\u00edv enteropathi\u00e1s betegek t\u00f6bb mint 50%-\u00e1nak t\u00fcnetei at\u00edpusosak, \u00e9s az extragastrointestinalis manifeszt\u00e1ci\u00f3j\u00fa coeliaki\u00e1ban szenved\u0151 betegek 90%-\u00e1nak nincs gastrointestinalis t\u00fcnete. Jelenleg a coeliakia diagnosztik\u00e1ja a specifikus autoantitestek kimutat\u00e1s\u00e1n \u00e9s a duodenum sz\u00f6vettani \u00e9rt\u00e9kel\u00e9s\u00e9n alapszik. Kezeletlen betegek eset\u00e9n a fels\u0151 standard endoszk\u00f3pia sor\u00e1n a nyomb\u00e9lben j\u00f3l l\u00e1that\u00f3k a boholyatrophia makroszk\u00f3pos elt\u00e9r\u00e9sei (Kerking-red\u0151zet elsimul\u00e1sa, a ny\u00e1lkah\u00e1rty\u00e1n \u00e1tt\u0171n\u0151 \u00e9rrajzolat, a mucosa mozaikszer\u0171 rajzolata vagy granul\u00e1lts\u00e1ga \u00e9s a f\u00e9s\u0171fogszer\u0171 red\u0151zet kialakul\u00e1sa). A kapszul\u00e1s endoszk\u00f3pia (CE) a hagyom\u00e1nyos endoszk\u00f3pos m\u00f3dszerekkel szemben a teljes v\u00e9konyb\u00e9l noninvaz\u00edv, f\u00e1jdalmatlan vizsg\u00e1lat\u00e1t teszi lehet\u0151v\u00e9. A vizsg\u00e1latok sor\u00e1n a v\u00e9konyb\u00e9l-ny\u00e1lkah\u00e1rtya 8:1 ar\u00e1ny\u00fa nagy\u00edt\u00e1sban v\u00e1lik l\u00e1that\u00f3v\u00e1, ami gyakorlott vizsg\u00e1l\u00f3 sz\u00e1m\u00e1ra lehet\u0151v\u00e9 teszi a boholyatrophia meg\u00edt\u00e9l\u00e9s\u00e9t. Az els\u0151 tapasztalatok alapj\u00e1n \u00fagy t\u0171nik, hogy a standard fels\u0151 endoszk\u00f3pia \u00e9s a kapszul\u00e1s endoszk\u00f3pia szenzitivit\u00e1sa \u00e9s specificit\u00e1sa azonos coeliaki\u00e1ban. A CE el\u0151ny\u00e9t a fels\u0151 endoszk\u00f3pi\u00e1val szemben a v\u00e9konyb\u00e9l teljes \u00e9rt\u00e9kelhet\u0151s\u00e9ge jelenti, mert \u00edgy a betegs\u00e9g kiterjed\u00e9se \u00e9s s\u00falyoss\u00e1ga is meg\u00edt\u00e9lhet\u0151. H\u00e1tr\u00e1nya a hisztol\u00f3giai mintav\u00e9tel hi\u00e1nya. Bizony\u00edtottan coeliaki\u00e1ban szenved\u0151 betegek eset\u00e9ben, \u201ealarm\u201d t\u00fcnetek jelentkez\u00e9sekor a CE \u201efirst line\u201d m\u00f3dszerk\u00e9nt javasolhat\u00f3.<\/jats:p>","DOI":"10.1556\/oh.2008.28468","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T14:16:22Z","timestamp":1223475382000},"page":"1951-1955","source":"Crossref","is-referenced-by-count":0,"title":["Small intestine capsule endoscopy in the diagnostics of coeliac disease"],"prefix":"10.1556","volume":"149","author":[{"given":"M\u00e1rta","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"1 Vaszary Kolos K\u00f3rh\u00e1z II. 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