{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:15:17Z","timestamp":1752228917352},"reference-count":37,"publisher":"Akademiai Kiado Zrt.","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,1]]},"abstract":"<jats:p>A gastrointestinalis rendszer egyr\u00e9szt a f\u00fcggetlen enteralis idegrendszer ir\u00e1ny\u00edt\u00e1sa alatt \u00e1ll, m\u00e1sr\u00e9szt szorosan kapcsol\u00f3dik a k\u00f6zponti idegrendszerhez, \u00e9s k\u00f6z\u00f6tt\u00fck bidirekcion\u00e1lis kommunik\u00e1ci\u00f3 van. E kommunik\u00e1ci\u00f3 neuralis p\u00e1ly\u00e1kon, immun- \u00e9s endokrin mechanizmusokon kereszt\u00fcl t\u00f6rt\u00e9nik. Az agy-b\u00e9l tengely kiemelked\u0151 fontoss\u00e1g\u00fa a b\u00e9lfunkci\u00f3 modul\u00e1l\u00e1s\u00e1ban. K\u00fcl\u00f6nb\u00f6z\u0151 eredet\u0171 szign\u00e1lok (hang, l\u00e1tv\u00e1ny, szag, szomatikus \u00e9s visceralis esem\u00e9nyek, f\u00e1jdalom) jutnak el az agyhoz, amelyeket a mem\u00f3ria, kognit\u00edv \u00e9s affekt\u00edv mechanizmusok m\u00f3dos\u00edtanak, ezut\u00e1n integr\u00e1l\u00f3dnak a k\u00f6zponti idegrendszer, a gerincvel\u0151, az auton\u00f3m \u00e9s enteralis idegrendszer k\u00f6reiben. Fiziol\u00f3giai hat\u00e1sokat v\u00e1ltanak ki, megv\u00e1ltoztatj\u00e1k a motilit\u00e1st, a szekr\u00e9ci\u00f3t, az immunfunkci\u00f3t, a gastrointestinalis traktus v\u00e9r\u00e1t\u00e1raml\u00e1s\u00e1t. Az egyik f\u0151 neurotranszmitter a szerotonin, amely kulcsszerepet j\u00e1tszik a leggyakoribb kr\u00f3nikus, funkcion\u00e1lis gastrointestinalis betegs\u00e9g, az irrit\u00e1bilis b\u00e9l szindr\u00f3ma patogenezis\u00e9ben. Ez a biopszichoszoci\u00e1lis k\u00f3rk\u00e9p az agy-b\u00e9l tengely diszregul\u00e1ci\u00f3j\u00e1nak k\u00f6vetkezm\u00e9nye, ahol az endog\u00e9n f\u00e1jdalomg\u00e1tl\u00e1s helyett a f\u00e1jdalom facilit\u00e1ci\u00f3ja l\u00e9p fel, a visceralis percepci\u00f3 patol\u00f3gi\u00e1s m\u00e9rt\u00e9kben fokoz\u00f3dik, \u00e9s a f\u00e1jdalomk\u00fcsz\u00f6b cs\u00f6kken. A betegek anamn\u00e9zis\u00e9ben igen gyakori az elszenvedett er\u0151szakos esem\u00e9ny, szem\u00e9lyis\u00e9gvon\u00e1saik k\u00f6z\u00fcl leggyakrabban a t\u00falzott lelkiismeretess\u00e9get, a perfekcionizmust, a t\u00fal\u00e9rz\u00e9kenys\u00e9get, a hat\u00e9konys\u00e1g\u00e9rz\u00e9s hi\u00e1ny\u00e1t, a nagyobb szoci\u00e1lis megfelel\u00e9s ir\u00e1nti ig\u00e9nyt, a neuroticizmust \u00e9s az alexithymi\u00e1t \u00edrj\u00e1k le. N\u0151kre jellemz\u0151 a nemi szerepkonfliktus \u00e9s az alacsony asszertivit\u00e1s. Kezel\u00e9s\u00fckben az antidepressz\u00e1nsoknak \u00e9s a pszichoter\u00e1pi\u00e1s m\u00f3dszereknek egyar\u00e1nt szerep\u00fck van. A neuroticizmus \u00e9s az alexithymia a gyullad\u00e1sos b\u00e9lbetegs\u00e9gben szenved\u0151kre is jellemz\u0151, anamn\u00e9zis\u00fckben gyakori a zavart anya-gyermek kapcsolat. Szokv\u00e1nyos \u00e9s korai neurol\u00f3giai sz\u00f6v\u0151dm\u00e9ny az auton\u00f3m neuropathia. A refluxbetegs\u00e9g \u00e9s az obstrukt\u00edv alv\u00e1si apnoe k\u00f6lcs\u00f6n\u00f6sen gener\u00e1lj\u00e1k egym\u00e1st, s\u00falyoss\u00e1guk korrel\u00e1l. Coeliaki\u00e1ban a leggyakoribb neurol\u00f3giai manifeszt\u00e1ci\u00f3 az ataxia, a polyneuropathia \u00e9s a myopathia. A sz\u00f6vettanilag igazolt coeliaki\u00e1k 85%-\u00e1ban nem jelentkeznek gastrointestinalis t\u00fcnetek, ez\u00e9rt idiopathi\u00e1s ataxia eset\u00e9n igen fontos az antigliadinantitest-titer m\u00e9r\u00e9se. A glut\u00e9nmentes \u00e9trend a neurol\u00f3giai t\u00fcnetek teljes regresszi\u00f3j\u00e1t eredm\u00e9nyezheti.<\/jats:p>","DOI":"10.1556\/oh.2008.28480","type":"journal-article","created":{"date-parts":[[2008,10,24]],"date-time":"2008-10-24T12:14:30Z","timestamp":1224850470000},"page":"2079-2086","source":"Crossref","is-referenced-by-count":9,"title":["Neurological and psychiatric aspects of some gastrointestinal diseases"],"prefix":"10.1556","volume":"149","author":[{"given":"Zsuzsa","family":"Aszal\u00f3s","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"RA125","volume":"10","year":"2004","journal-title":"Med. Sci. 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