{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T19:42:57Z","timestamp":1694634177550},"reference-count":28,"publisher":"Akademiai Kiado Zrt.","issue":"47","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,1]]},"abstract":"<jats:p>Tanulm\u00e1nyunk c\u00e9lja volt megvizsg\u00e1lni, hogy az ism\u00e9telt ischaemi\u00e1s prekondicion\u00e1l\u00e1s, illetve az N-acetilcisztein-ter\u00e1pia befoly\u00e1solj\u00e1k-e kedvez\u0151 hemodinamikai hat\u00e1suk r\u00e9v\u00e9n az ischaemi\u00e1s-reperf\u00fazi\u00f3s s\u00e9r\u00fcl\u00e9st kutyam\u00e1jban.<jats:italic>M\u00f3dszer:<\/jats:italic>A kontrollcsoport (<jats:italic>n<\/jats:italic>= 10) 60 perc m\u00e1jischaemi\u00e1n esett \u00e1t, majd ezt k\u00f6vet\u0151en 180 perc reperf\u00fazi\u00f3ban r\u00e9szes\u00fclt. Az N-acetilcisztein-csoport (<jats:italic>n<\/jats:italic>= 5) intrav\u00e9n\u00e1san 150 mg kg<jats:sup>\u20131<\/jats:sup>N-acetilciszteint kapott az ischaemia megkezd\u00e9se el\u0151tt. A prekondicion\u00e1lt csoportba tartoz\u00f3 k\u00eds\u00e9rleti \u00e1llatok (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) ischaemi\u00e1s prekondicion\u00e1l\u00e1sban r\u00e9szes\u00fcltek (10 perc ischaemi\u00e1s peri\u00f3dus ut\u00e1n 10 perc reperf\u00fazi\u00f3, ism\u00e9telve h\u00e1romszor) a\u00a0portalis tri\u00e1sz lefog\u00e1sa el\u0151tt.<jats:italic>Eredm\u00e9nyek:<\/jats:italic>Tizennyolc k\u00eds\u00e9rleti \u00e1llat \u00e9lte t\u00fal a vizsg\u00e1lati id\u0151szakot. Az N-acetilcisztein-csoportba tartoz\u00f3 k\u00eds\u00e9rleti \u00e1llatok k\u00f6z\u00fcl egy kutya elhalt inotrop kezel\u00e9sre nem reag\u00e1l\u00f3 kering\u00e9si el\u00e9gtelens\u00e9g k\u00f6vetkez\u00e9ben. A sz\u00edvindex \u00e9s az intrathoracicus v\u00e9r volumenindexe szignifik\u00e1nsan magasabb volt a prekondicion\u00e1lt csoportban a kontrollcsoporthoz viszony\u00edtva, v\u00e9gig a vizsg\u00e1lati peri\u00f3dus sor\u00e1n.<jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>A kapott adatok arra engednek k\u00f6vetkeztetni, hogy az ism\u00e9telt ischaemi\u00e1s prekondicion\u00e1l\u00e1s jav\u00edthat a hemodinamikai param\u00e9tereken, mindamellett az N-acetilcisztein-kezel\u00e9ssel kapcsolatban nem tudtunk szignifik\u00e1ns k\u00fcl\u00f6nbs\u00e9get kimutatni.<\/jats:p>","DOI":"10.1556\/oh.2008.28495","type":"journal-article","created":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T22:53:18Z","timestamp":1226616798000},"page":"2245-2249","source":"Crossref","is-referenced-by-count":1,"title":["Hemodynamic effects of N-acetylcystein and ischemic preconditioning in a liver ischemia-reperfusion model"],"prefix":"10.1556","volume":"149","author":[{"given":"Subhamay","family":"Ghosh","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Klinika Budapest K\u00fatv\u00f6lgyi u. 4. 1125"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"\u2020Baumann","sequence":"additional","affiliation":[{"name":"2 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogl\u00e1rka","family":"Falusi","sequence":"additional","affiliation":[{"name":"2 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Bog\u00e1r","sequence":"additional","affiliation":[{"name":"2 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"R\u0151th","sequence":"additional","affiliation":[{"name":"3 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Seb\u00e9szeti Oktat\u00f3- \u00e9s Kutat\u00f3int\u00e9zet P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"G\u00e1l","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Klinika Budapest K\u00fatv\u00f6lgyi u. 4. 1125"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1001\/archsurg.1995.01430070076015","volume":"130","year":"1995","journal-title":"Arch. 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