{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:18:38Z","timestamp":1773274718301,"version":"3.50.1"},"reference-count":51,"publisher":"Akademiai Kiado Zrt.","issue":"51","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:p>Az id\u00fclt m\u00e1jbetegs\u00e9gek kezel\u00e9s\u00e9re csak a k\u00f3roki folyamatok ismeret\u00e9ben tudunk c\u00e9lzott ter\u00e1pi\u00e1t v\u00e1lasztani. Az oxidat\u00edv stressz okozta m\u00e1jk\u00e1rosod\u00e1sban (alkoholos \u00e9s nem alkoholos m\u00e1jbetegs\u00e9g, gy\u00f3gyszer \u00e9s vegyszer okozta megbeteged\u00e9sek) az antioxid\u00e1ns tulajdons\u00e1g\u00fa szerek, mint p\u00e9ld\u00e1ul a silymarin, a v\u00edrusos eredet\u0171 kr\u00f3nikus hepatitisekben (hepatitis B- \u00e9s hepatitis C-v\u00edrus-fert\u0151z\u00e9s) pedig a kombin\u00e1lt peginterferon + nukleozidanal\u00f3g kezel\u00e9s az els\u0151dlegesen v\u00e1lasztand\u00f3 szer. A silymarin f\u0151 tulajdons\u00e1gai: membr\u00e1nstabiliz\u00e1l\u00f3 \u00e9s antioxid\u00e1ns hat\u00e1s, el\u0151seg\u00edti a m\u00e1jsejt-regener\u00e1ci\u00f3t, cs\u00f6kkenti a gyullad\u00e1sos aktivit\u00e1st \u00e9s g\u00e1tolja a fibrogenezist. Mindezt k\u00eds\u00e9rletes \u00e9s klinikai vizsg\u00e1latok is igazolt\u00e1k. Ny\u00edlt vizsg\u00e1latok szerint a silymarin tart\u00f3s alkalmaz\u00e1sa az alkoholos eredet\u0171 m\u00e1jcirrhosisban szenved\u0151 betegek t\u00fal\u00e9l\u00e9si idej\u00e9t jelent\u0151s m\u00e9rt\u00e9kben n\u00f6velte. Leg\u00fajabban kimutatt\u00e1k, hogy nagy d\u00f3zis\u00fa silibinininf\u00fazi\u00f3 hepatitis C-v\u00edrus okozta kr\u00f3nikus hepatitisben n\u00e9gyhetes kezel\u00e9s sor\u00e1n jelent\u0151s m\u00e9rt\u00e9kben cs\u00f6kkentette a hepatitis C-v\u00edrus-sz\u00e1mot. A leg\u00fajabb molekul\u00e1ris biol\u00f3giai vizsg\u00e1latok igazolt\u00e1k, hogy a silymarin, a fenti kor\u00e1bban bizony\u00edtott hat\u00e1sa mellett, jelent\u0151s m\u00e9rt\u00e9kben k\u00e9pes cs\u00f6kkenteni a daganatossejt-prolifer\u00e1ci\u00f3t, az angiogenezist, valamint az inzulinrezisztenci\u00e1t. Mindezen tulajdons\u00e1gok alapj\u00e1n a mai korszer\u0171 betegell\u00e1t\u00e1sban a silymarink\u00e9sz\u00edtm\u00e9nyek alkalmaz\u00e1sa a kr\u00f3nikus m\u00e1jbetegs\u00e9gek kezel\u00e9s\u00e9ben, els\u0151sorban az alkoholos \u00e9s nem alkoholos steatohepatitisben, hely\u00e9nval\u00f3 \u00e9s v\u00e1rhat\u00f3an a j\u00f6v\u0151ben is az lesz. Bizonyos tumoros betegs\u00e9gekben pedig adjuv\u00e1ns kezel\u00e9sk\u00e9nt ker\u00fclhetnek alkalmaz\u00e1sra.<\/jats:p>","DOI":"10.1556\/oh.2008.28519","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T03:33:58Z","timestamp":1228966438000},"page":"2413-2418","source":"Crossref","is-referenced-by-count":15,"title":["Silymarin in the treatment of chronic liver diseases: past and future"],"prefix":"10.1556","volume":"149","author":[{"given":"J\u00e1nos","family":"Feh\u00e9r","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Lengyel","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"Free radical reaction in biology and medicine","year":"1987"},{"key":"atypb2","volume-title":"Hepatol\u00f3gia","year":"2001"},{"key":"atypb3","first-page":"105","volume":"9","year":"1989","journal-title":"J. Hepatol."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0140-6736(01)06102-5","volume":"358","year":"2001","journal-title":"Lancet"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMoa020047","volume":"347","year":"2002","journal-title":"N. Engl. 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