{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:12:37Z","timestamp":1694635957824},"reference-count":27,"publisher":"Akademiai Kiado Zrt.","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>A daganatos megbeteged\u00e9sek elleni k\u00fczdelem hat\u00e1soss\u00e1g\u00e1ban a multidrog-rezisztencia k\u00e9rd\u00e9s\u00e9nek megold\u00e1sa fontos szerepet j\u00e1tszik. N\u00f6vekv\u0151 ig\u00e9ny mutatkozik olyan \u00faj vegy\u00fcletek kifejleszt\u00e9s\u00e9re, amelyek k\u00e9pesek g\u00e1tolni a k\u00fcl\u00f6nb\u00f6z\u0151 rezisztenciamechanizmusokat. C\u00e9lul t\u0171zt\u00fck ki a szintetikus (cinnamilid\u00e9n-ketonok; 1,4-dihidropiridin \u00e9s fenotiazinsz\u00e1rmaz\u00e9kok; h\u0151sokkfeh\u00e9rje-90-g\u00e1tl\u00f3 peptidek \u00e9s Tilozin betti b\u00e1zis\u00fa sz\u00e1rmaz\u00e9k), valamint term\u00e9szetes (<jats:italic>Euphorbia<\/jats:italic>-diterp\u00e9nek) n\u00f6v\u00e9nyi alkot\u00f3kb\u00f3l kivont sz\u00e1rmaz\u00e9kok multidrog-rezisztenci\u00e1\u00e9rt felel\u0151s effluxpumpa-g\u00e1tl\u00e1s\u00e1nak vizsg\u00e1lat\u00e1t k\u00fcl\u00f6nb\u00f6z\u0151 sejtvonalakon, rem\u00e9lve, hogy a verapamilt\u00f3l kev\u00e9sb\u00e9 toxikus, de ann\u00e1l hat\u00e1sosabb rezisztenciam\u00f3dos\u00edt\u00f3 vegy\u00fcleteket tal\u00e1lunk. A t\u00e9zis els\u0151 r\u00e9sze a vizsg\u00e1lt vegy\u00fcletek P-glikoprotein effluxpumpa-g\u00e1tl\u00f3 hat\u00e1s\u00e1t mutatja be k\u00fcl\u00f6nb\u00f6z\u0151 sejtvonalakon. \u00c1ltal\u00e1noss\u00e1gban elmondhat\u00f3, hogy az \u00fajonnan azonos\u00edtott rezisztenciam\u00f3dos\u00edt\u00f3 vegy\u00fcletek k\u00e9pesek voltak a kiv\u00e1lasztott r\u00e1kellenes szerek sejtszaporod\u00e1s-g\u00e1tl\u00f3 hat\u00e1s\u00e1nak fokoz\u00e1s\u00e1ra, k\u00f6cs\u00f6nhat\u00e1suk szinergiz\u00e1l\u00f3 vagy addit\u00edv hat\u00e1st mutatott<jats:italic>in vitro<\/jats:italic>k\u00eds\u00e9rletekben. A Tilozin betti b\u00e1zis\u00fa sz\u00e1rmaz\u00e9k<jats:italic>in vitro<\/jats:italic>k\u00eds\u00e9rletekben tapasztalt hat\u00e1s\u00e1t, tov\u00e1bbi<jats:italic>in vivo<\/jats:italic>, DBA\/2 eg\u00e9r modellek al\u00e1t\u00e1masztott\u00e1k. Az antitumorhat\u00e1s vizsg\u00e1lat\u00e1nak egy alternat\u00edv \u00fatja a k\u00fcl\u00f6nb\u00f6z\u0151 vegy\u00fcletekkel kiv\u00e1ltott apopt\u00f3zis folyamata. A leg\u00edg\u00e9retesebb apopt\u00f3zisinduk\u00e1l\u00f3nak a dihidropiridin 13 bizonyult. A latr\u00e1n vegy\u00fcletek antiprom\u00f3ci\u00f3s hat\u00e1s\u00e1nak<jats:italic>in vitro<\/jats:italic>modellez\u00e9s\u00e9hez hum\u00e1n cytomegalovirussal fert\u0151z\u00f6tt hum\u00e1n t\u00fcd\u0151r\u00e1ksejteket haszn\u00e1ltunk. A\u00a0vizsg\u00e1lt makrociklikus latr\u00e1n t\u00edpus\u00fa diterp\u00e9n vegy\u00fcletek t\u00f6bbs\u00e9ge, kiv\u00e9ve a latilagascene D vegy\u00fclet, k\u00e9pes volt a cytomegalovirus korai antig\u00e9n-kifejez\u0151d\u00e9s\u00e9nek g\u00e1tl\u00e1s\u00e1ra.<\/jats:p>","DOI":"10.1556\/oh.2009.28358","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T01:01:45Z","timestamp":1237338105000},"page":"607-614","source":"Crossref","is-referenced-by-count":0,"title":["Perspectives of inhibition of multidrug resistance during cancer chemotherapy, in vitro and in vivo experiments"],"prefix":"10.1556","volume":"150","author":[{"given":"Helga","family":"Engi","sequence":"first","affiliation":[{"name":"1 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Orvosi Mikrobiol\u00f3giai \u00e9s Immunobiol\u00f3giai Int\u00e9zet Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/annonc\/mdl498","volume":"18","year":"2007","journal-title":"Ann. 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