{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:13:47Z","timestamp":1718669627752},"reference-count":25,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:p>Az emberi l\u00e9g\u00fati \u00f3ri\u00e1ssejtes v\u00edrus (hRSV) a csecsem\u0151- \u00e9s kisgyermekkori l\u00e9g\u00fati fert\u0151z\u00e9sek, j\u00e1rv\u00e1nyok egyik leggyakoribb k\u00f3rokoz\u00f3ja vil\u00e1gszerte. A hRSV molekul\u00e1ris epidemiol\u00f3gi\u00e1ja nem ismert haz\u00e1nkban, ma azonban m\u00e1r lehet\u0151s\u00e9g van a v\u00edrus genetikai szint\u0171 kimutat\u00e1s\u00e1ra \u00e9s nyomon k\u00f6vet\u00e9s\u00e9re e m\u00f3dszerrel. \n <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n A szerz\u0151k c\u00e9lja a hRSV molekul\u00e1ris kimutat\u00e1sa \u00e9s a v\u00edrusok genetikai elemz\u00e9se volt gyermekkori l\u00e9g\u00fati fert\u0151z\u00e9sekb\u0151l haz\u00e1nkban. \n <jats:italic>M\u00f3dszer:<\/jats:italic>\n A garatmos\u00f3 folyad\u00e9kok a mosd\u00f3si k\u00f3rh\u00e1zban kezelt 10 \u00e9v alatti, l\u00e9g\u00fati fert\u0151z\u00e9sben szenved\u0151 gyermekekt\u0151l sz\u00e1rmaztak k\u00e9t l\u00e9g\u00fati szezonb\u00f3l (2005\/2006 \u00e9s 2006\/2007) okt\u00f3ber 15. \u00e9s m\u00e1jus 15. k\u00f6z\u00f6tt. A klinikai \u00e9s epidemiol\u00f3giai adatokat prospekt\u00edv m\u00f3don, formanyomtatv\u00e1nyokon gy\u0171jt\u00f6tt\u00fck. A vir\u00e1lis RNS f\u00fazi\u00f3s (F) \u00e9s glikoprotein (G) g\u00e9nj\u00e9nek felsokszoroz\u00e1s\u00e1t RT-PCR m\u00f3dszerrel v\u00e9gezt\u00fck, majd a term\u00e9keket szekven\u00e1ltuk \u00e9s filogenetikailag elemezt\u00fck. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A 104 l\u00e9g\u00fati mint\u00e1b\u00f3l 23 (22,1%) \u2013 16 fi\u00fa (69,6%) \u00e9s 7 l\u00e1ny (30,4%) \u2013 tartalmazott hRSV-t (az els\u0151 szezonban: 1\/49, 2%; a m\u00e1sodik szezonban: 22\/55, 40%). A hRSV-fert\u0151z\u00e9sek december \u00e9s m\u00e1rcius k\u00f6z\u00f6tt t\u00f6rt\u00e9ntek. Az \u00e1tlag\u00e9letkor 2,1 \u00e9v (1 h\u00f3nap\u20138 \u00e9v) volt. A vezet\u0151 t\u00fcnetek a k\u00f6vetkez\u0151k voltak: orrfoly\u00e1s, l\u00e1z, k\u00f6h\u00f6g\u00e9s \u00e9s l\u00e9g\u00fati nehez\u00edtetts\u00e9g. A hRSV-fert\u0151z\u00f6tt gyermekek 39,1%-\u00e1nak voltak alapbetegs\u00e9gei. Az F-r\u00e9gi\u00f3 alapj\u00e1n 22 (96%) v\u00edrusgenetikailag az A t\u00edpusba tartozott, 1 (4%) a B t\u00edpusba volt sorolhat\u00f3. A 11 A t\u00edpus\u00fa v\u00edrus k\u00f6z\u00fcl 8 (72,7%) a GA5-\u00f6s, 3 (27,3%) a GA2-es csoportba tartozik a G-r\u00e9gi\u00f3 alapj\u00e1n. A\u00a0v\u00edrusok nukleotidsorrendje t\u00f6bb esetben azonos volt. \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n A k\u00f6zlem\u00e9nyben a hRSV k\u00e9t t\u00edpus\u00e1nak (A \u00e9s B) \u2013 tudom\u00e1sunk szerint \u2013 els\u0151 hazai, k\u00f6zvetlen molekul\u00e1ris kimutat\u00e1s\u00e1r\u00f3l \u00e9s elemz\u00e9s\u00e9r\u0151l sz\u00e1molunk be, 10 \u00e9ven aluli gyermekek l\u00e9g\u00fati fert\u0151z\u00e9seib\u0151l. A hRSV a gyermekkori, els\u0151sorban a csecsem\u0151kori k\u00f3rh\u00e1zi kezel\u00e9st ig\u00e9nyl\u0151 l\u00e9g\u00fati fert\u0151z\u00e9sek jelent\u0151s k\u00f3roki t\u00e9nyez\u0151je a t\u00e9li-tavaszi h\u00f3napokban.<\/jats:p>","DOI":"10.1556\/oh.2009.28473","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T02:08:06Z","timestamp":1231380486000},"page":"121-127","source":"Crossref","is-referenced-by-count":3,"title":["Detection and molecular epidemiology of respiratory syncytial virus type A and B strains in childhood respiratory infections in Hungary"],"prefix":"10.1556","volume":"150","author":[{"given":"P\u00e9ter","family":"Pankovics","sequence":"first","affiliation":[{"name":"1 \u00c1llami N\u00e9peg\u00e9szs\u00e9g\u00fcgyi \u00e9s Tisztiorvosi Szolg\u00e1lat D\u00e9l-dun\u00e1nt\u00fali Region\u00e1lis Int\u00e9zete Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium P\u00e9cs Szabads\u00e1g u. 7. 7623"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajnalka","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"2 Magyarorsz\u00e1gi Reform\u00e1tus Egyh\u00e1z Mosd\u00f3si T\u00fcd\u0151- \u00e9s Sz\u00edvk\u00f3rh\u00e1za (Kaposi M\u00f3r Oktat\u00f3 K\u00f3rh\u00e1z) Mosd\u00f3s"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6ngyi","family":"Sz\u00e9kely","sequence":"additional","affiliation":[{"name":"2 Magyarorsz\u00e1gi Reform\u00e1tus Egyh\u00e1z Mosd\u00f3si T\u00fcd\u0151- \u00e9s Sz\u00edvk\u00f3rh\u00e1za (Kaposi M\u00f3r Oktat\u00f3 K\u00f3rh\u00e1z) Mosd\u00f3s"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1lm\u00e1n","family":"Gyurkovits","sequence":"additional","affiliation":[{"name":"2 Magyarorsz\u00e1gi Reform\u00e1tus Egyh\u00e1z Mosd\u00f3si T\u00fcd\u0151- \u00e9s Sz\u00edvk\u00f3rh\u00e1za (Kaposi M\u00f3r Oktat\u00f3 K\u00f3rh\u00e1z) Mosd\u00f3s"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Reuter","sequence":"additional","affiliation":[{"name":"1 \u00c1llami N\u00e9peg\u00e9szs\u00e9g\u00fcgyi \u00e9s Tisztiorvosi Szolg\u00e1lat D\u00e9l-dun\u00e1nt\u00fali Region\u00e1lis Int\u00e9zete Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium P\u00e9cs Szabads\u00e1g u. 7. 7623"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"Fields Virology, Volume 2","year":"2007"},{"key":"atypb2","first-page":"2299","volume":"147","year":"2006","journal-title":"Orv. 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