{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T20:10:11Z","timestamp":1710015011870},"reference-count":48,"publisher":"Akademiai Kiado Zrt.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2,1]]},"abstract":"<jats:p>A simvastatin (SIM) ritka \u00e9s s\u00falyos mell\u00e9khat\u00e1sa a har\u00e1ntcs\u00edkolt izomzat sz\u00e9tes\u00e9se, a rhabdomyolysis (RML). A folyamat patogenezis\u00e9ben t\u00f6bb rizik\u00f3faktor szerep\u00e9t le\u00edrt\u00e1k, mint p\u00e9ld\u00e1ul a &gt;65 \u00e9v, cukorbetegs\u00e9g, vesebetegs\u00e9g, nagy adagban adott statinkezel\u00e9s, citokr\u00f3m P450 3A4 \u00fatj\u00e1n metaboliz\u00e1l\u00f3d\u00f3 vegy\u00fcletek vagy az egy\u00e9ni \u00e9rz\u00e9kenys\u00e9g.<jats:italic>Esetismertet\u00e9s:<\/jats:italic>A fentiek k\u00f6z\u00fcl n\u00e9gy rizik\u00f3faktorral rendelkez\u0151 66 \u00e9ves f\u00e9rfi beteg\u00fcnk 2-es t\u00edpus\u00fa diabetes, ISZB \u00e9s hypertonia miatt \u00e1llt kezel\u00e9s alatt. CYP3A4-szubsztr\u00e1t amlodipint \u00e9s alprazolamot kapott. Ismeretlen kiindul\u00e1si koleszterinszint mellett maxim\u00e1lis d\u00f3zis\u00fa SIM-kezel\u00e9s indult. M\u00e1snapra vizeletelsz\u00ednez\u0151d\u00e9s, paraparesis, a negyedik napra tetraparesis \u00e9s oliguria jellemezte a heveny veseel\u00e9gtelens\u00e9ggel j\u00e1r\u00f3 RML kialakul\u00e1s\u00e1t. A sz\u00e1zhat nap k\u00f3rh\u00e1zi \u00e1pol\u00e1s alatt negyvenkilenc alkalommal r\u00e9szes\u00fclt dial\u00edziskezel\u00e9sben. Elbocs\u00e1t\u00e1s ut\u00e1ni tizenhat h\u00f3nap ut\u00e1nk\u00f6vet\u00e9s alatt a beteg j\u00e1r\u00e1sa oly m\u00e9rt\u00e9kben javult, hogy egy j\u00e1r\u00f3bot seg\u00edts\u00e9g\u00e9vel k\u00f6zlekedik.<jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>A fent eml\u00edtett rizik\u00f3faktorok miatt, ebben az esetben, alacsony kezd\u0151 d\u00f3zis\u00fa SIM alkalmaz\u00e1sa lett volna k\u00edv\u00e1natos. Izomf\u00e1jdalom vagy gyenges\u00e9g kialakul\u00e1sakor a kezel\u00e9s le\u00e1ll\u00edt\u00e1sa indokolt. RML-re hajlamos\u00edt\u00f3 t\u00e9nyez\u0151k eset\u00e9n a statinkezel\u00e9s \u00e9s adagj\u00e1nak emel\u00e9se szoros ellen\u0151rz\u00e9s mellett t\u00f6rt\u00e9nhet.<\/jats:p>","DOI":"10.1556\/oh.2009.28498","type":"journal-article","created":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T02:07:19Z","timestamp":1233281239000},"page":"265-269","source":"Crossref","is-referenced-by-count":1,"title":["Maximal initiative dose of simvastatin causing acute renal failure through rhabdomyolysis: risk factors, pathomechanism and therapy related to a case"],"prefix":"10.1556","volume":"150","author":[{"given":"D\u00e1niel","family":"Deme","sequence":"first","affiliation":[{"name":"1 Szent L\u00e1z\u00e1r Megyei K\u00f3rh\u00e1z Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Salg\u00f3tarj\u00e1n Salg\u00f3 \u00fat 4. 3100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aref","family":"Al-Hadad","sequence":"additional","affiliation":[{"name":"1 Szent L\u00e1z\u00e1r Megyei K\u00f3rh\u00e1z Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Salg\u00f3tarj\u00e1n Salg\u00f3 \u00fat 4. 3100"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fcnde","family":"Varga","sequence":"additional","affiliation":[{"name":"2 Szent L\u00e1z\u00e1r Megyei K\u00f3rh\u00e1z Fresenius MC Dial\u00edzis K\u00f6zpont Salg\u00f3tarj\u00e1n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Sz\u00e1nt\u00f3","sequence":"additional","affiliation":[{"name":"2 Szent L\u00e1z\u00e1r Megyei K\u00f3rh\u00e1z Fresenius MC Dial\u00edzis K\u00f6zpont Salg\u00f3tarj\u00e1n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"S\u00e1ndor","sequence":"additional","affiliation":[{"name":"3 Szent L\u00e1z\u00e1r Megyei K\u00f3rh\u00e1z Intenz\u00edv Oszt\u00e1ly Salg\u00f3tarj\u00e1n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ervin","family":"Rakonczai","sequence":"additional","affiliation":[{"name":"1 Szent L\u00e1z\u00e1r Megyei K\u00f3rh\u00e1z Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Salg\u00f3tarj\u00e1n Salg\u00f3 \u00fat 4. 3100"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/bmj.327.7407.115","volume":"327","year":"2003","journal-title":"BMJ"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejim.2006.07.030","volume":"18","year":"2007","journal-title":"Eur. J. Intern. Med."},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/09273940701375147","volume":"15","year":"2007","journal-title":"Ocul. Immunol. Inflamm."},{"key":"atypb4","first-page":"1258","volume":"28","year":"2005","journal-title":"Diabet. Care"},{"key":"atypb5","first-page":"295","volume":"22","year":"1999","journal-title":"Clin. Neuropharmacol."},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1345\/aph.1G462","volume":"40","year":"2006","journal-title":"Ann. Pharmacother."},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1515\/DMDI.2007.22.2-3.195","volume":"22","year":"2007","journal-title":"Drug Metabol. Drug Interact."},{"key":"atypb8","first-page":"514","volume":"129","year":"1999","journal-title":"Schweiz. Med. Wochenschr."},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0027-9684(15)31280-3","volume":"100","year":"2008","journal-title":"J. Natl. Med. Assoc."},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(05)78613-X","volume":"351","year":"1998","journal-title":"Lancet"},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3122\/jabfm.2007.04.060187","volume":"20","year":"2007","journal-title":"J. Am. Board. Fam. Med."},{"key":"atypb12","first-page":"172","volume":"10","year":"2003","journal-title":"Can. J. Clin. Pharmacol."},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-2044.2007.05434.x","volume":"63","year":"2008","journal-title":"Anaesthesia"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000049053","volume":"90","year":"2002","journal-title":"Nephron"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1086\/344179","volume":"35","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"atypb16","first-page":"234","volume":"50","year":"2004","journal-title":"J. Postgrad. Med."},{"key":"atypb17","first-page":"339","volume":"94","year":"2001","journal-title":"Tenn. Med."},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/00007611-199705000-00018","volume":"90","year":"1997","journal-title":"South Med. J."},{"key":"atypb19","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1097\/01.SMJ.0000078621.31517.30","volume":"96","year":"2003","journal-title":"South Med. J."},{"key":"atypb20","first-page":"719","volume":"38","year":"2004","journal-title":"Ann. Pharmacother."},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3816\/CLC.2008.n.036","volume":"9","year":"2008","journal-title":"Clin. Lung Cancer"},{"key":"atypb22","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1097\/00007890-200206270-00022","volume":"73","year":"2002","journal-title":"Transplantation"},{"key":"atypb23","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1157\/13110470","volume":"129","year":"2007","journal-title":"Med. Clin. (Barc)."},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/RHU.0b013e318156d977","volume":"13","year":"2007","journal-title":"J. Clin. Rheumatol."},{"key":"atypb25","first-page":"597","volume":"36","year":"2007","journal-title":"Age Ageing"},{"key":"atypb26","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1345\/aph.1A058","volume":"36","year":"2002","journal-title":"Ann. Pharmacother."},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1046\/j.1365-2796.1999.00610.x","volume":"246","year":"1999","journal-title":"J. Intern. Med."},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1136\/heart.90.1.e3","volume":"90","year":"2004","journal-title":"Heart"},{"key":"atypb29","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2165\/00003088-200443130-00003","volume":"43","year":"2004","journal-title":"Clin. Pharmacokinet."},{"key":"atypb30","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1124\/dmd.107.020255","volume":"36","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"atypb31","first-page":"1","volume":"29","year":"1995","journal-title":"Clin. Pharmacokinet."},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1046\/j.1365-2125.1997.00644.x","volume":"44","year":"1997","journal-title":"Br. J. Clin. Pharmacol."},{"key":"atypb33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1211\/0022357022566","volume":"56","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1124\/jpet.301.1.160","volume":"301","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2174\/157488406776872550","volume":"1","year":"2006","journal-title":"Curr. Clin. Pharmacol."},{"key":"atypb36","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0009-9236(95)90249-X","volume":"58","year":"1995","journal-title":"Clin. Pharmacol. Ther."},{"key":"atypb37","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1001\/jama.292.21.2585","volume":"292","year":"2004","journal-title":"JAMA"},{"key":"atypb38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1515\/CCLM.2000.002","volume":"38","year":"2000","journal-title":"Clin. Chem. Lab. Med."},{"key":"atypb39","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/carcin\/bgi329","volume":"27","year":"2006","journal-title":"Carcinogenesis"},{"key":"atypb40","first-page":"31","volume":"54","year":"2001","journal-title":"Magy. Belorv. Arch."},{"key":"atypb41","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1124\/jpet.105.086462","volume":"314","year":"2005","journal-title":"JPET"},{"key":"atypb42","volume-title":"Klinikai nephrologia","year":"2004"},{"key":"atypb43","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/pds.1287","volume":"16","year":"2007","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"atypb44","doi-asserted-by":"crossref","first-page":"23K","DOI":"10.1016\/S0002-9149(03)00779-3","volume":"92","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"atypb45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.atherosclerosis.2006.10.001","volume":"195","year":"2007","journal-title":"Atherosclerosis"},{"key":"atypb46","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1345\/aph.1C029","volume":"36","year":"2002","journal-title":"Ann. Pharmacother."},{"key":"atypb47","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/pds.1602","volume":"17","year":"2008","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"atypb49","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2165\/00002018-200629110-00005","volume":"29","year":"2006","journal-title":"Drug Saf."}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/150\/6\/article-p265.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/150\/6\/article-p265.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T19:54:57Z","timestamp":1710014097000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/150\/6\/article-p265.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,1]]},"references-count":48,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1556\/oh.2009.28498","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,1]]}}}