{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T17:03:58Z","timestamp":1648659838321},"reference-count":47,"publisher":"Akademiai Kiado Zrt.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>A dolgozat t\u00e9m\u00e1ja egyfel\u0151l k\u00e9t pszichopatol\u00f3giai t\u00fcnet elemz\u00e9se egy hossz\u00fa t\u00e1v\u00fa ut\u00e1nk\u00f6vet\u00e9ses vizsg\u00e1lat \u2013 \u201eBudapest 2000\u201d \u2013 keret\u00e9ben els\u0151sorban szkizofr\u00e9ni\u00e1ban szenved\u0151 n\u0151betegek k\u00f6r\u00e9ben; m\u00e1sfel\u0151l a genetikai prediszpoz\u00edci\u00f3hoz k\u00f6zelinek tartott kognit\u00edv endofenotipikus von\u00e1s \u2013 az asszociat\u00edv tanul\u00e1s \u00e9s tanult ekvivalencia \u2013 vizsg\u00e1lata szkizofr\u00e9n betegek \u00e9s hozz\u00e1juk illesztett eg\u00e9szs\u00e9ges kontrollok csoportjaiban. \n <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n I. Megvizsg\u00e1lni 1. a t\u00e9veszme \u00e9s a hallucin\u00e1ci\u00f3 s\u00falyoss\u00e1g\u00e1t, annak id\u0151beli v\u00e1ltoz\u00e1s\u00e1t, el\u0151fordul\u00e1s\u00e1nak val\u00f3sz\u00edn\u0171s\u00e9g\u00e9t az egyes klinikai csoportokban; 2. a klinikai csoportokra jellemz\u0151 k\u00f3rlefoly\u00e1st a k\u00e9t t\u00fcnet alapj\u00e1n. II.\u00a0Tanulm\u00e1nyozni az asszoci\u00e1ci\u00f3s tanul\u00e1s \u00e9s a tanult ekvivalencia jelens\u00e9g\u00e9t abban az \u00f6sszef\u00fcgg\u00e9sben, hogy ezek a k\u00e9pess\u00e9gek elk\u00fcl\u00f6n\u00edtik-e a szkizofr\u00e9n betegeket az eg\u00e9szs\u00e9ges kontrollcsoportt\u00f3l, illetve a szkizofr\u00e9ni\u00e1n bel\u00fcl elk\u00fcl\u00f6n\u00fclnek-e a deficit- \u00e9s nem deficitszkizofr\u00e9nia-alcsoportok. \n <jats:italic>M\u00f3dszerek:<\/jats:italic>\n Az els\u0151, klinikai t\u00fcneteket elemz\u0151 vizsg\u00e1latban 221 n\u0151beteg vett r\u00e9szt, a t\u00fcneteket a Rockland\u2013Pollin-f\u00e9le becsl\u00e9ssk\u00e1la, valamint a Saj\u00e1tos t\u00fcnetek list\u00e1ja seg\u00edts\u00e9g\u00e9vel \u00e9rt\u00e9kelt\u00fck a betegs\u00e9g heveny szak\u00e1ban (indexid\u0151pont), valamint 5 \u00e9vvel \u00e9s 21\u201333 \u00e9vvel az indexid\u0151pontot k\u00f6vet\u0151en. Diagnosztikus besorol\u00e1suk eredetileg Leonhard rendszere szerint t\u00f6rt\u00e9nt, de elv\u00e9gezt\u00fck a DSM-IV szerinti diagnosztiz\u00e1l\u00e1sukat is. A m\u00e1sodik vizsg\u00e1lat keret\u00e9ben 49 szkizofr\u00e9n f\u00e9rfi \u00e9s n\u0151beteget, valamint 20 illesztett eg\u00e9szs\u00e9ges kontrollt vizsg\u00e1ltunk meg a Rutgers-f\u00e9le tanultekvivalencia-teszt, valamint h\u00e1rom, d\u00f6nt\u0151en front\u00e1lis neuropszichol\u00f3giai teszt seg\u00edts\u00e9g\u00e9vel. Az ut\u00f3bbi vizsg\u00e1lat keret\u00e9ben a klinikai t\u00fcneteket a Positive and negative symptom scale-lel m\u00e9rt\u00fck. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A pozit\u00edv dimenzi\u00f3 t\u00fcneteinek v\u00e1ltoz\u00e1s\u00e1ban a hossz\u00fa t\u00e1v\u00fa lefoly\u00e1s sor\u00e1n k\u00fcl\u00f6nbs\u00e9g mutatkozik: hallucin\u00e1ci\u00f3 s\u00falyoss\u00e1g\u00e1ban az 5 \u00e9ves vizsg\u00e1lat ut\u00e1ni id\u0151szakban szignifik\u00e1ns roml\u00e1s van, m\u00edg a t\u00e9veszme m\u00e9rs\u00e9kl\u0151dik, de ez a javul\u00e1s nem szignifik\u00e1ns. A k\u00e9t t\u00fcnet, valamint a szoci\u00e1lis funkcion\u00e1l\u00e1s tekintet\u00e9ben elk\u00fcl\u00f6n\u00fcl egym\u00e1st\u00f3l az affekt\u00edv, cikloid \u00e9s szkizofr\u00e9n betegek csoportja az ut\u00e1nk\u00f6vet\u00e9s id\u0151szaka alatt, \u00e9s a k\u00e9t t\u00fcnet jellemz\u0151i szerint a paranoid, hebefr\u00e9n \u00e9s katat\u00f3n alcsoportok is. A\u00a0medi\u00e1lis temporalis lebeny m\u0171k\u00f6d\u00e9s\u00e9vel kapcsolatos tanultekvivalencia-vizsg\u00e1latban a szkizofr\u00e9n betegek rosszabbul teljes\u00edtettek, mint az eg\u00e9szs\u00e9ges kontrollcsoport. Az agyt\u00f6rzsi magvak medi\u00e1lta asszociat\u00edv tanul\u00e1sban ny\u00fajtott teljes\u00edtm\u00e9ny\u00fck elk\u00fcl\u00f6n\u00edtette a deficit- vs. nem deficitszkizofr\u00e9n alcsoportot. \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n 1. A kognit\u00edv dimenzi\u00f3 elk\u00fcl\u00f6n\u00edti a szkizofr\u00e9nia deficit- \u00e9s nem deficitalcsoportjait. 2. A pozit\u00edv dimenzi\u00f3 t\u00fcnetei alapj\u00e1n a szkizofr\u00e9nia klasszikus t\u00edpusai v\u00e1lnak sz\u00e9t.<\/jats:p>","DOI":"10.1556\/oh.2009.28530","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T04:58:57Z","timestamp":1236315537000},"page":"423-429","source":"Crossref","is-referenced-by-count":0,"title":["Psychopathologic and cognitive investigations in schizophrenia"],"prefix":"10.1556","volume":"150","author":[{"given":"M\u00e1rta","family":"Farkas","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem Ment\u00e1lis Eg\u00e9szs\u00e9gtudom\u00e1nyok Doktori Iskola Budapest Balassa u. 6. 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"3","year":"2006","journal-title":"Neuropsychopharmacole. 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