{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T12:22:41Z","timestamp":1648815761703},"reference-count":23,"publisher":"Akademiai Kiado Zrt.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>A hepatitis E-v\u00edrus (HEV) az egyik leggyakoribb, sz\u00e9klettel terjed\u0151, hepatitist okoz\u00f3 \u00e1gens a fejl\u0151d\u0151 orsz\u00e1gokban. A fejlett orsz\u00e1gokban a v\u00edrus sz\u00f3rv\u00e1nyos emberi megbeteged\u00e9sekb\u0151l \u00e9s h\u00e1zisert\u00e9sekb\u0151l val\u00f3 kimutat\u00e1sa azonban felveti a HEV zoonosis \u00fatj\u00e1n val\u00f3 terjed\u00e9s\u00e9t is. \n <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n A hepatitis E-v\u00edrus kimutat\u00e1sa emberben, h\u00e1zi- (sert\u00e9s, szarvasmarha) \u00e9s vadon \u00e9l\u0151 (vaddiszn\u00f3, \u0151z) \u00e1llatokban, \u00e9s a v\u00edrus molekul\u00e1ris epidemiol\u00f3gi\u00e1ja haz\u00e1nkban. \n <jats:italic>M\u00f3dszer:<\/jats:italic>\n A szerz\u0151k a 2001 \u00e9s 2006 k\u00f6z\u00f6tt a szegedi v\u00e1rosi k\u00f3rh\u00e1z infektol\u00f3giai oszt\u00e1ly\u00e1n ismeretlen eredet\u0171 hepatitisben szenved\u0151 betegek sz\u00e9rummint\u00e1it HEV ELISA m\u00f3dszerekkel el\u0151sz\u0171rt\u00e9k, majd a HEV-IgM-pozit\u00edv sz\u00e9rummint\u00e1kat \u00e9s az \u00e1llati b\u00e9ls\u00e1r-, m\u00e1j-, valamint b\u00e9lmint\u00e1kat RT-PCR m\u00f3dszerekkel vizsg\u00e1lt\u00e1k. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n \u00d6sszesen 116 (9,6%) beteg sz\u00e9rummint\u00e1ja tartalmazott HEV-IgM ellenanyagot. \u00d6tvenh\u00e1rom HEV-IgM-pozit\u00edv sz\u00e9rummint\u00e1b\u00f3l 13-ban (24,5%) a HEV is kimutathat\u00f3 volt RT-PCR \u00e9s szekven\u00e1l\u00e1si m\u00f3dszerekkel. A sert\u00e9smint\u00e1kb\u00f3l 42 minta (b\u00e9ls\u00e1r: 22,7%, m\u00e1j: 30,8%), az \u0151zmint\u00e1kb\u00f3l 11 (m\u00e1j: 34,4%) \u00e9s a vaddiszn\u00f3mint\u00e1kb\u00f3l 9 minta (m\u00e1j: 12,2%) mutatott RT-PCR-pozitivit\u00e1st. Egy Indi\u00e1b\u00f3l import\u00e1lt 1-es genot\u00edpus\u00fa HEV v\u00edruson k\u00edv\u00fcl minden tov\u00e1bbi HEV (12 hum\u00e1n, 19 sert\u00e9s, 3 \u0151z, 2 vaddiszn\u00f3) a 3-as genot\u00edpusba tartozik. Genetikailag megegyez\u0151 szekvenci\u00e1j\u00fa HEV-et lehetett kimutatni \u0151zb\u0151l \u00e9s egy emberi fert\u0151z\u00e9sb\u0151l, tov\u00e1bb\u00e1 k\u00e9t-k\u00e9t emberi fert\u0151z\u00e9sb\u0151l. \n <jats:italic>Megbesz\u00e9l\u00e9s:<\/jats:italic>\n A HEV end\u00e9mi\u00e1san jelen l\u00e9v\u0151 k\u00f3rokoz\u00f3. A nyers vagy nem kell\u0151en h\u0151kezelt h\u00fasterm\u00e9kek (h\u00e1zi \u00e9s vadh\u00fas) elfogyaszt\u00e1sa a legval\u00f3sz\u00edn\u0171bb forr\u00e1sa a hazai sz\u00f3rv\u00e1nyos hepatitis E-fert\u0151z\u00e9seknek. A 3-as genot\u00edpus\u00fa HEV-ek okozta end\u00e9mi\u00e1s hum\u00e1n fert\u0151z\u00e9sek fajokon kereszt\u00fcli zoonosisok, amelyek \u00e9lelmiszerek k\u00f6zvet\u00edt\u00e9s\u00e9vel terjednek haz\u00e1nkban.<\/jats:p>","DOI":"10.1556\/oh.2009.28561","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T04:58:57Z","timestamp":1236315537000},"page":"415-421","source":"Crossref","is-referenced-by-count":0,"title":["Molecular epidemiology of hepatitis E virus in Hungary: endemic, food-borne zoonosis"],"prefix":"10.1556","volume":"150","author":[{"given":"G\u00e1bor","family":"Reuter","sequence":"first","affiliation":[{"name":"1 Gastroenteralis V\u00edrusok Nemzeti Referencia Laborat\u00f3riuma, \u00c1NTSZ D\u00e9l-dun\u00e1nt\u00fali Region\u00e1lis Int\u00e9zete Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium P\u00e9cs Szabads\u00e1g u. 7. 7623"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domonka","family":"Fodor","sequence":"additional","affiliation":[{"name":"2 Szeged Megyei Jog\u00fa V\u00e1ros \u00d6nkorm\u00e1nyzata V\u00e1rosi K\u00f3rh\u00e1za Infektol\u00f3giai Oszt\u00e1ly Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Forg\u00e1ch","sequence":"additional","affiliation":[{"name":"3 Szent Istv\u00e1n Egyetem, \u00c1llatorvos-tudom\u00e1nyi Kar Mikrobiol\u00f3giai Int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"K\u00e1tai","sequence":"additional","affiliation":[{"name":"4 \u00c1NTSZ D\u00e9l-alf\u00f6ldi Region\u00e1lis Int\u00e9zete Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Sz\u0171cs","sequence":"additional","affiliation":[{"name":"1 Gastroenteralis V\u00edrusok Nemzeti Referencia Laborat\u00f3riuma, \u00c1NTSZ D\u00e9l-dun\u00e1nt\u00fali Region\u00e1lis Int\u00e9zete Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium P\u00e9cs Szabads\u00e1g u. 7. 7623"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"Fields Virology","year":"2001"},{"key":"atypb2","volume-title":"Manual of Clinical Microbiology","year":"2003"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1128\/JCM.40.1.117-122.2002","volume":"40","year":"2002","journal-title":"J. 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