{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T05:33:31Z","timestamp":1648791211645},"reference-count":14,"publisher":"Akademiai Kiado Zrt.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>A szerz\u0151 r\u00f6viden \u00f6sszefoglalja a Down-szindr\u00f3ma fontosabb klinikai t\u00fcneteit \u00e9s a megel\u0151z\u00e9s lehet\u0151s\u00e9geit. Ismerteti a sz\u0171r\u00e9sre haszn\u00e1lt m\u00f3dszereket (biok\u00e9miai markerek, magzati ultrahangjelek) \u00e9s a legfontosabb sz\u0171r\u0151teszteket (kombin\u00e1lt teszt, integr\u00e1lt teszt). Ezt k\u00f6vet\u0151en a Down-sz\u0171r\u00e9s hazai helyzet\u00e9t elemzi, \u00e9s hangs\u00falyozza, hogy a 35 \u00e9v feletti anyai \u00e9letkor, tov\u00e1bb\u00e1 az alacsonyabb sz\u00e9rum-alfa-fetoprotein-szint \u00f6nmag\u00e1ban nem lehet az amniocentesis indik\u00e1ci\u00f3ja. Els\u0151rend\u0171 feladat a betegs\u00e9g felismer\u00e9si ar\u00e1ny\u00e1nak n\u00f6vel\u00e9se \u00e9s az amniocentesisek sz\u00e1m\u00e1nak cs\u00f6kkent\u00e9se. A jelenleg ismert leghat\u00e9konyabb sz\u0171r\u0151m\u00f3dszer az els\u0151 trimeszteri kombin\u00e1lt teszt. Ennek orsz\u00e1gos bevezet\u00e9s\u00e9hez az ultrahang-diagnosztika szem\u00e9lyi \u00e9s t\u00e1rgyi felt\u00e9teleinek jav\u00edt\u00e1s\u00e1n \u00e9s a megfelel\u0151 finansz\u00edroz\u00e1s megold\u00e1s\u00e1n \u00e1t vezethet az \u00fat.<\/jats:p>","DOI":"10.1556\/oh.2009.28568","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T02:06:56Z","timestamp":1236132416000},"page":"497-502","source":"Crossref","is-referenced-by-count":0,"title":["Meditation about the screening of Down syndrome"],"prefix":"10.1556","volume":"150","author":[{"given":"S\u00e1ndor","family":"Gard\u00f3","sequence":"first","affiliation":[{"name":"1 Petz Alad\u00e1r Megyei Oktat\u00f3 K\u00f3rh\u00e1z Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Gy\u0151r Pf. 92. 9002"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"Klinikai genetika","year":"1995"},{"key":"atypb2","first-page":"2293","volume":"141","year":"2000","journal-title":"Orv. 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